Results of Long Term Experimental Constriction of the Hepatic Veins in Dogs

Armstrong, Charles D.

doi:10.1001/archsurg.1944.01230010485008

Cited by 8 publications

(3 citation statements)

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“…Rarely, sudden complete occlusion of the main hepatic vein occurs and results in acute congestive hepatic necrosis, vomiting, variable amounts of ascites, and death within hours to days (Zimmerman & Hillsman, 1930). The Budd-Chiari syndrome can be produced experimentally in dogs by hepatic vein occlusion (Armstrong & Richards 1944;Widman et al, 1962) or by partial ligation of the intrathoracic CVC (Volwider et al, 1960;Witte et al, 1969). Obstruction of the entrance of the CVC into the right atrium by an aortic body tumour resulted in chronic signs of the Budd-Chiari syndrome (ascites and hepatomegaly) in a dog (Edwards et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

Kinking of the intrathoracic caudal vena cava in five dogs

Cornelius

Mahaffey

1985

J of Small Animal Practice

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Five dogs with kinking of the intrathoracic caudal vena cava (CVC) were studied. One dog had neither clinical nor laboratory abnormalities associated with the kinked CVC, and the cause was unknown. The other four dogs had evidence of post‐sinusoidal obstruction of venous flow characterized by high protein ascites (modified transudate). Causes of the kinked CVC were automobile trauma (two dogs), cardiomegaly with ascites, and a large neoplastic lung mass. Surgical removal of the kinked caval segment was successful in the two dogs injured by automobiles. Medical therapy with a diuretic was associated with a decrease in ascites, straightening of the CVC, and improvement in clinical condition of the dog with cardiomegaly and ascites. Surgical removal of the neoplastic lung mass in one dog resulted in straightening of the CVC, but it later died of respiratory failure associated with pulmonary neoplasia.

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Section: Discussionmentioning

confidence: 99%

Kinking of the intrathoracic caudal vena cava in five dogs

Cornelius

Mahaffey

1985

J of Small Animal Practice

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“…Through the courtesy of the Winthrop Chemical Company, we were able to obtain a supply of such a sodium-free mixture. 1 Mter a 3 week rest period on a high protein diet, the final week of which is recorded in Table 4, dog 42-893 was placed on the standard low protein diet for 2½ weeks. The results of these two trials agreed with previous data.…”

Section: Experimental Observationsmentioning

confidence: 99%

Protein Metabolism and Exchange as Influenced by Constriction of the Vena Cava

McKee

Schloerb

Schilling

et al. 1948

Journal of Experimental Medicine

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Workers in this laboratory have long been interested in the production of plasma proteins and the fluid exchange.which goes on between the circulating plasma proteins and various body tissues. Ascites comes into consideration in such relation and the experimental method of vena cava constriction was used to study the body protein exchange due to ascites. As the experiments continued it was obvious that this method presented an admirable technique for the study of ascites and some of the related medical problems. Furthermore, the ascites was not complicated by the presence of extensive liver pathology and was due to venous stasis in the portal area. Ascites was produced in the dog by placing a constricting aluminum band on the inferior vena cava between the diaphragm and the right auricle.This method of vena cava constriction was used by one of us (G. H. W.) in 19(O-10 to produce ascites. The partial obstruction was caused by sutures put in the vena cava to produce narrowing of the lumen. This condition would last many weeks and then the sutures would cut through with relief of the obstruction and complete absorption of large amounts of ascitic fluid in a matter of hours. In these experiments there was no significant liver pathology remaining after relief of the obstruction. As these earlier experiments were incidental to a study of liver abnormalities (17) they were soon discontinued.The tables below show clearly that vena cava obstruction and the resultant ascites may produce a considerable drain on protein reserve stores and a hypoproteinemia. As the ascitic fluid is removed at frequent intervals, there results a continuing internal plasraapheresis. The term plasmapkeresis as used here means the removal of whole blood with subsequent replacement of the red cells suspended in a salt solution. As the procedure is used day by day one observes an hypoproteinemia which can be maintained for months at an even level. This technique has been used extensively to study the production of new plasma proteins as influenced by diet factors

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“…However, EVB is one of the severest complications in portal hypertension. Many scholars have attempted to establish the model of esophageal varices in animals experiments using the aforementioned methods, but they have failed in experiments on dogs, mice and rats [19][20][21]. Although the development of varicose veins similar to those of human beings under esophageal mucosa has been successfully accomplished in rhesus monkeys, the application of this model is limited, due to high costs, limited source, and high demand for their housing and care.…”

Section: Introductionmentioning

confidence: 99%