The spectrum of indications for heavy tamponades is constantly expanding. In addition to retinal detachment and PVR surgery, macular holes, reopened macular holes and central retinal detachments or foveoschisis associated with high myopia seem to be the most important diseases that are currently treated with heavy tamponades with good to excellent results published so far. However, a comprehensive comparison with conventional tamponades cannot be made at present because of the limited number of patients and studies published on this subject.