Results of external beam radiotherapy for diffuse choroidal hemangiomas in Sturge–Weber syndrome

Randon, Matthieu; Lévy-Gabriel, Christine; Abbas, Rachid; Dendale, R.; Lumbroso, Livia; Desjardins, Laurence; Cassoux, Nathalie

doi:10.1038/s41433-018-0024-4

Cited by 19 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Randon et al investigated external beam radiotherapy (20 Gy in 10 fractions) in a large series (26 eyes of 25 patients) with diffuse CH. [76] The treatment resulted in tumor regression; the mean thickness reached from 4.5 mm at baseline to 2.8 mm in the first year, and 2.7 mm at the last visit. The retinal detachment was resolved in all except two patients.…”

Section: Managementmentioning

confidence: 87%

See 1 more Smart Citation

Ocular Manifestations of the Sturge–Weber Syndrome

Hassanpour

Nourinia

Gerami

et al. 2021

JOVR

View full text Add to dashboard Cite

Sturge–Weber syndrome (SWS) or encephalotrigeminal angiomatosis is a non-inherited congenital disorder characterized by neurologic, skin, and ocular abnormalities. A somatic activating mutation (R183Q) in the GNAQ gene during early embryogenesis has been recently recognized as the etiology of vascular abnormalities in SWS. Approximately, half of the patients with SWS manifest ocular involvement including glaucoma as the most common ocular abnormality followed by choroidal hemangioma (CH). The underlying pathophysiology of glaucoma in SWS has not been completely understood yet. Early onset glaucoma comprising 60% of SWS glaucoma have lower success rates after medical and surgical treatments compared with primary congenital glaucoma. Primary angle surgery is associated with modest success in the early onset SWS glaucoma while the success rate significantly decreases in late onset glaucoma. Filtration surgery is associated with a higher risk of intraoperative and postoperative choroidal effusion and suprachoroidal hemorrhage. CH is reported in 40–50% of SWS patients. The goal of treatment in patients with CH is to induce involution of the hemangioma, with reduction of subretinal and intraretinal fluid and minimal damage to the neurosensory retina. The decision for treating diffuse CHs highly depends on the patient’s visual acuity, the need for glaucoma surgery, the presence of subretinal fluid (SRF), its chronicity, and the potential for visual recovery.

show abstract

Section: Managementmentioning

confidence: 87%

“…Randon et al [76] 2018 External beam radiotherapy (20 Gy in 10 fractions) 26 eyes of 25 patients Five years (4-41) years Reduced tumor thickness (4.5 mm, 2.7 mm at the last visit)…”

Section: Outcomementioning

confidence: 99%

Ocular Manifestations of the Sturge–Weber Syndrome

Hassanpour

Nourinia

Gerami

et al. 2021

JOVR

View full text Add to dashboard Cite

show abstract

“…9 Though these choroidal hemangiomas are congenital, exudative retinal detachment may occur at any age and observed in approximately half of patients with SWS. 12 The management of glaucoma in SWS is still debatable. 7 Medical treatments in SWS patients may not ensure a good long-term control of glaucoma, hence a surgical approach is mandatory in these type of cases.…”

Section: Discussionmentioning

confidence: 99%

Spectrum of Microbial Keratitis in the Mid-Western Region of Nepal

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In contrast, the most widely available linear accelerator (LINAC) generated radiation therapy treatment volume can uniformly include the entire tumor and a free-margin. [1516171819] External beam radiation therapy (EBRT) does not require real-time tumor visualization as does laser. LINAC-generated EBRT can uniformly treat sections of or the entire eye as needed for circumscribed or diffuse uveal hemangiomas, respectively.…”

Section: Radiation Therapymentioning

confidence: 99%

“…[15] However, consider that there exists: electrons, X-rays, photons, charged-particles, neutrons as well as ruthenium-106, iodine-125, palladium-103, cesium-131, iridium-192, strontium-90, and others. [1516171819202122]…”

Section: Radiation: Ready Shoot Aim?mentioning

confidence: 99%