Abstract:The main aim of this systematic review was to analyse and compare the clinical efficacy and safety of metronidazole, vancomycin and fidaxomicin in the therapy of C. difficile infection. Methods: Systematic review and meta-analysis of the literature using Bayesian mixed treatment comparison. Results: Nine studies were included in the mixed-treatment comparison. Our meta-analysis showed that clinical cure was more likely with fidaxomicin compared to vancomycin and metronidazole, however the differences were not … Show more
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