Results of a 90-day safety assessment study in mice fed a glucan produced by Agrobacterium sp. ZX09

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

“…The structure of salecan is a linear (1→3)-␤-d-glucan consisted of ␤-1-3-linked glucopyranosyls with a small quantity of ␣-1-3-linked [33]. As a novel polysaccharide, salecan has been utilized in the fields of both food and medical in our laboratory [34][35][36][37][38]. With a high density of hydroxyl groups, the large molecular weighted (2 × 10 6 Da) salecan could be further modified for multifarious applications.…”

Laxative effects of Salecan on normal and two models of experimental constipated mice

“…ZX09, mainly composed of β-(1→3)-D-glucosidic linkages as the main backbone structure, together with a small portion of α-(1→3)-D-glucosidic linkages [20]. Salecan is a non-toxic and water-soluble beta-glucan with excellent rheological properties [21,23]. Bacterial extracellular polysaccharides (e.g.…”

“…ZX09, is a novel high molecular, water-soluble extracellular polysaccharide, and its structure is proven to consist of the following repeating unit:→3)-β-D-Glcp-(1→3)-[ β-D-Glcp-(1→3)-β-D-Glcp-(1→3)]3-α-D-Glcp-(1→3)-α-D-Glcp-(1→ [20]. As a new beta-glucan with special molecular structure, its safety has been demonstrated in the acute and subchronic experiment [21]. Supplementation with Salecan reduced adiposity and improved glucose tolerance in high-fat diet-fed mice through disturbing bile acid-promoted emulsification in intestine [22].…”

A Novel Soluble Beta-Glucan Salecan Protects against Acute Alcohol-Induced Hepatotoxicity in Mice

“…Acute and subchronic experiments demonstrated the safety properties of this glucan. 20) Also, salecan alone did not affect normal hepatic activity. 21) Hence salecan can be used as hepatotherapeutic agent.…”