A Novel Soluble Beta-Glucan Salecan Protects against Acute Alcohol-Induced Hepatotoxicity in Mice

Chen, Peng; Wang, Zhongqiu; Zeng, Lingbing; Yang, Xiao; Wang, Shiming; Dong, Wei; Jia, Ai‐Qun; Cai, Chun; Zhang, Jianfa

doi:10.1271/bbb.110412

Cited by 21 publications

(10 citation statements)

References 21 publications

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“…β -glucans are naturally occurring polysaccharides with poly-branched β -(1-3)- d -glucans or β -(1-6)- d -glucose side chains, and are widely distributed in the cell walls of fungi or bacteria, cereal plants, and seaweeds [ 13 , 14 ]. A number of studies have reported the biological functions of β -glucans, such as modulating the immune system, protecting against tumors, and reducing the absorption of cholesterol and fat [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice

Yang

et al. 2018

Nutrients

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Fatigue induced by prolonged exercise not only leads to the decrease of exercise capacity, but also might be the cause of many diseases. In consideration of the side effects of pharmacological drugs, dietary supplements seem to be a better choice to ameliorate exercise-induced fatigue. The present study aimed to investigate the anti-fatigue effect of Salecan, a novel water-soluble β-glucan, during exercise and explore the underlying mechanisms. Male Institute of Cancer Research (ICR) mice were divided into five groups, including the Rest group and the other four Swim-groups treated with Salecan at 0, 25, 50, and 100 mg/kg/day for four weeks. Salecan treatment markedly increased the exhaustive swimming time of mice in the forced swimming test. Exercise fatigue and injury-related biochemical biomarkers including lactate, blood urea nitrogen (BUN), creatinine kinase (CK), alanine transaminase (ALT), and aspartate transaminase (AST) were ameliorated by Salecan. Salecan reversed the decreased serum glucose levels and glycogen contents caused by exercise. In addition, Salecan improved oxidative stress induced by exercise through regulating Nrf2/HO–1/Trx signaling pathway. Thus, the beneficial effects of Salecan against fatigue may be due to its positive effects on energy metabolism and antioxidation defence. Our results suggest that Salecan could be a novel potential candidate for anti-fatigue dietary supplements.

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Section: Introductionmentioning

confidence: 99%

β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice

Yang

et al. 2018

Nutrients

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“…The structure of salecan is a linear (1→3)-␤-d-glucan consisted of ␤-1-3-linked glucopyranosyls with a small quantity of ␣-1-3-linked [33]. As a novel polysaccharide, salecan has been utilized in the fields of both food and medical in our laboratory [34][35][36][37][38]. With a high density of hydroxyl groups, the large molecular weighted (2 × 10 6 Da) salecan could be further modified for multifarious applications.…”

Section: Introductionmentioning

confidence: 99%

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

Wei

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…All mice were housed and maintained in a specific pathogen-free facility of Laboratory Animal Resource Center of KRIBB (temperature of 22±2°C, relative humidity of 50–60%, ammonia concentration less than 1 ppm, and 12-h light/dark cycle) and were given ad libitum access to food and water. All mice received a single dose of ethanol [6 g/kg body weight, 25% (v/v) solution, n=30 for each SHP-KO mice or WT mice] or PBS (control, n=20 for each SHP-KO mice or WT mice) intragastrically to induce acute alcohol-associated liver injury, according to a previously reported method ( 19 , 20 ), and were euthanized 12 h post-treatment. A total of 9–11 mice were used for both control groups and 15 mice used for both alcohol groups.…”

Section: Methodsmentioning

confidence: 99%

Small heterodimer partner deficiency exacerbates binge drinking‑induced liver injury via modulation of natural killer T cell and neutrophil infiltration

Noh

Hwang

et al. 2018

Mol Med Report

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Binge drinking among alcohol consumers is a common occurrence, and may result in the development of numerous diseases, including liver disorders. It has previously been reported that natural killer T (NKT) cells induce alcohol-associated liver injury by promoting neutrophil infiltration. In the present study, the role of the orphan nuclear receptor small heterodimer partner (SHP), which is encoded by the NR0B2 gene, in acute binge drinking-induced liver injury was investigated. SHP-knockout (KO) and wild-type (WT) control mice were intragastrically administered single doses of alcohol. The plasma concentrations of alanine aminotransferase and aspartate aminotransferase in SHP-KO mice following alcohol treatment were significantly increased compared with WT mice. However, results of oil red O staining and 2′,7′-dichlorodihydrofluorescein diacetate staining indicated that levels of acute binge drinking-associated hepatic lipid accumulation and oxidative stress were not significantly different between WT and SHP-KO alcohol-treated mice. Notably, tumor necrosis factor-α mRNA expression in the liver of SHP-KO mice was significantly increased following alcohol administration, compared with WT mice. Furthermore, the mRNA expression levels of C-C motif chemokine ligand 2, C-X-C motif chemokine ligand 2 and interleukin-4, which are all potent chemoattractants of NKT cells, as well as neutrophil expression levels, were significantly increased in the livers of SHP-KO mice compared with WT mice following alcohol administration, as determined by reverse transcription-quantitative polymerase chain reaction and flow cytometry. Enhanced infiltration of NKT cells, determined by flow cytometry, was also demonstrated in the livers of SHP-KO mice following alcohol administration, compared with WT mice. The results of the present study indicate that SHP may be involved in liver-associated protective mechanisms, with regards to the attenuation of damage caused by acute binge drinking, via regulation of NKT cell and neutrophil migration to the liver. The modulation of SHP may be a novel therapeutic strategy for the treatment of acute binge drinking-induced liver injury.

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A Novel Soluble Beta-Glucan Salecan Protects against Acute Alcohol-Induced Hepatotoxicity in Mice

Cited by 21 publications

References 21 publications

β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice

β-glucan Salecan Improves Exercise Performance and Displays Anti-Fatigue Effects through Regulating Energy Metabolism and Oxidative Stress in Mice

A novel thermo-responsive hydrogel based on salecan and poly(N-isopropylacrylamide): Synthesis and characterization

Small heterodimer partner deficiency exacerbates binge drinking‑induced liver injury via modulation of natural killer T cell and neutrophil infiltration

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