Clusterizations, mergers, and acquisitions of university institutions are carried out to provide a framework for the development of development policies, the development of higher education, and to enable universities to enhance their competencies, their higher education standards, and also the quality of the effective implementation of the Tri Dharma of higher education. Clusterizations classify universities according to their level of growth so that they can act as a source of knowledge on the standard of higher education performance in Indonesia for the general public. In the meantime, acquisitions and mergers are carried out not only to reduce the number of universities but also to improve the competence and standards of higher education. The Indonesia higher education cluster classifies universities in Indonesia into five classes based on four main aspects, namely input, process, output, and outcome. There are three schemes for mergers and acquisitions: the merger of separate universities with the same base, the merger of universities with different foundations, and the merger of universities, large and small, with the same vision and mission. Meanwhile, the limited adequacy and suitability of lecturers after mergers and acquisitions, ownership of land and property after mergers and acquisitions, and a new undefined curriculum are the issues that obstruct the merger and acquisition stage of higher education. This hurdle makes universities unable to pursue the clustering method in the process of mergers and acquisitions. The recommendations for clusterizations are aimed at strengthening the capacity of higher education to develop an international reputation, strengthening internal resource management skills, promoting improved management systems, improving the quality of inputs and processes, and promoting understanding of the implementation of Tri Dharma. Then, for mergers and acquisitions, the government is required to take a strong stand in rationalizing the composition of lecturers and students, promoting the accreditation of study programs, monitoring transfers of leadership, planning criteria for the management of facilities and infrastructure, and respecting the rights and duties of lecturers and educational staff.