Restrictive Cardiomyopathy Due to Endocardial Invasion by Advanced Peripheral T-Cell Lymphom

Restrictive physiology masked by cardiac tamponade: A rare cooccurrence in a child with lymphoblastic T-cell lymphoma

“…In patients with lymphoma, dyspnea related to diastolic heart failure is scarcely reported in the literature. [ 4 5 6 7 ] The presence of pulmonary venous hypertension in chest X-ray and elevated NT pro-BNP support the diagnosis of heart failure in the index case. Although his hemodynamics improved, the persistence of PND after pericardiocentesis in our patient supports its origin to diastolic dysfunction because of RCM rather than cardiac tamponade.…”

“…The occurrence of RCM with lymphomas is extremely rare, and its evidence is limited to a few case reports. [ 4 5 6 ] Earlier studies have indicated toward a higher incidence of cardiomyopathy in patients with lymphoma. [ 10 ] Our patient developed cerebrovascular accident likely related to L-asparaginase therapy which is known to significantly increase the risk of thrombotic events (5.2%).…”

“…[ 3 ] Clinical presentation with restrictive cardiomyopathy (RCM) due to tumor infiltration is extremely rare in lymphoma. [ 4 5 6 ]…”

A rare presentation of Lymphoblastic T cell lymphoma with cardiac tamponade masking restrictive cardiomyopathy

“…Although dyspnea is common with pericardial involvement, associated orthopnea and PND, as in our case, should raise suspicion of underlying myocardial disease and warrants detailed echocardiographic reassessment after pericardiocentesis. The occurrence of restrictive cardiomyopathy with lymphomas is extremely rare, and its evidence is limited to a few case reports (4)(5)(6). Direct infiltration is the usual mechanism of restrictive physiology; however other non-infiltrative cytokinemediated mechanisms are possible.…”

“…Seldom detected clinically, the most common cardiac involvement detected on imaging is pericardial effusion with rare reports of endo-myocardial involvement (3). Clinical presentation with restrictive cardiomyopathy(RCM) due to tumor infiltration is extremely rare in lymphoma (4)(5)(6). We describe an unusual case of a 14-year-old boy with advanced T cell lymphoma presenting with cardiac tamponade.…”