Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour

O'Mahony, Conor; Sweeney, Fabian F.; Daly, Eoin; Dinan, Timothy G.; Cryan, John F.

doi:10.1016/j.bbr.2010.04.038

Cited by 70 publications

(51 citation statements)

References 57 publications

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“…The precise mediators between the gut microbiota and the vagus nerve have not been defined and could not therefore be assessed in this study. Moreover, it is important to note that the preclinical analysis of L. rhamnosus was carried out in BALB/c mice which are innately anxious and have different brain and gut responses to stress (Browne et al, 2011;Julio-Pieper et al, 2012;O'Mahony et al, 2010;.…”

Section: Discussionmentioning

confidence: 99%

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Kelly

Allen

Temko

et al. 2017

Brain, Behavior, and Immunity

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229

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Section: Discussionmentioning

confidence: 99%

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Kelly

Allen

Temko

et al. 2017

Brain, Behavior, and Immunity

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269

229

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“…The number of c-Fos-positive cells was measured in stress-related brain areas including the hippocampus, nucleus accumbens (NAcc), dorsal raphe nucleus (DRN), paraventricular nucleus (PVN), ventral tegmental area (VTA), medial prefrontal cortex, and amygdala. The PVN is known to be activated by restraint stress (21). Therefore, to evaluate the validity of our restraint stress paradigm, we first confirmed that it induced c-Fos activation in the PVN of the hypothalamus of WT mice that did not undergo early-life stress (Fig.…”

Section: Stress-induced Neural Activation Is Enhanced In Gaba B(1b)mentioning

confidence: 74%

“…In situ hybridization was conducted as previously described (41) Immunohistochemistry. c-Fos and doublecortin immunohistochemistry was conducted in female mice as previously described (21). BrdU and Ki67 immunohistochemistry was conducted in male mice as previously described (28).…”

Section: Methodsmentioning

confidence: 99%

GABA _B(1) receptor subunit isoforms differentially regulate stress resilience

O’Leary¹,

Felice

Galimberti³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Stressful life events increase the susceptibility to developing psychiatric disorders such as depression; however, many individuals are resilient to such negative effects of stress. Determining the neurobiology underlying this resilience is instrumental to the development of novel and more effective treatments for stress-related psychiatric disorders. GABA B receptors are emerging therapeutic targets for the treatment of stress-related disorders such as depression. These receptors are predominantly expressed as heterodimers of a GABA B(2) subunit with either a GABA B(1a) or a GABA B(1b) subunit. Here we show that mice lacking the GABA B(1b) receptor isoform are more resilient to both early-life stress and chronic psychosocial stress in adulthood, whereas mice lacking GABA B(1a) receptors are more susceptible to stress-induced anhedonia and social avoidance compared with wildtype mice. In addition, increased hippocampal expression of the GABA B(1b) receptor subunit is associated with a depression-like phenotype in the helpless H/Rouen genetic mouse model of depression. Stress resilience in GABA B(1b) −/− mice is coupled with increased proliferation and survival of newly born cells in the adult ventral hippocampus and increased stress-induced c-Fos activation in the hippocampus following early-life stress. Taken together, the data suggest that GABA B(1) receptor subunit isoforms differentially regulate the deleterious effects of stress and, thus, may be important therapeutic targets for the treatment of depression.neurogenesis | depression | anxiety | antidepressant

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“…It is straightforward, painless, and without lasting debilitation 14 . Moreover, restraint stress has been proved and used as a common stress inducing model [15][16][17] . Physical stress situations in rodents may be a useful model of early adversity and depression and the mechanism may involve alterations in neurotrophins 18,19 .…”

Section: Introductionmentioning

confidence: 99%

The neuroprotective effects of voluntary exercise in a restraint stress model

Jongkamonwiwat¹,

Krityakiarana²

2012

ScienceAsia

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Cell damage and cell generation can be altered in a stressed and exercised brain. However, it is not known whether voluntary exercise can prevent cell damage or cell death in stress situations, especially in the striatal region. To address this question, male Sprague-Dawley rats (3 months old) were separated into three groups (sedentary, restraint stress, and voluntary exercise + restraint stress groups). The stress circumstances were restraint stress, light stress, and tilt cage. To assess cell damage, staining for the heat shock protein (HSP90) was undertaken and the numbers of cells showing positive HSP90 expression were counted. Neurogenesis was investigated by staining for nestin markers. The restraint stress effects were assessed by determining the number of HSP90 expressed cells produced in the dorsal striatum. A significant difference was found when the number of HSP90 positive cells in the restraint stress and the voluntary exercise + restraint stress groups were compared to those in the sedentary control group. In both experimental conditions there was neurogenesis in the striatal area. However, the group that received voluntary exercise presented a significantly higher number of nestin-expressing cells over the restraint stress group. Voluntary exercise might have an adaptive effect on neurogenesis in terms of replenishing the cellular stressed neurons but it has no effect on ameliorating the level of stress marker. The evaluation of the effects of voluntary exercise on neurogenesis in the striatal region in the stressed model might contribute to a better understanding of beneficial interventions in movement disorders related to patients with depression.

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Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour

Cited by 70 publications

References 57 publications

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

GABA _B(1) receptor subunit isoforms differentially regulate stress resilience

The neuroprotective effects of voluntary exercise in a restraint stress model

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Restraint stress-induced brain activation patterns in two strains of mice differing in their anxiety behaviour

Cited by 70 publications

References 57 publications

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

Lost in translation? The potential psychobiotic Lactobacillus rhamnosus (JB-1) fails to modulate stress or cognitive performance in healthy male subjects

GABA B(1) receptor subunit isoforms differentially regulate stress resilience

The neuroprotective effects of voluntary exercise in a restraint stress model

Contact Info

Product

Resources

About

GABA _B(1) receptor subunit isoforms differentially regulate stress resilience