Methods: Fortymaleratswererandomlydividedintofourgroups:thecontrolgroupand thepreventive,therapeutic,andprotectiveexercisegroups.Thetreadmillrunningwasappliedat aspeedof20-21m/minandachronicstressof6hours/dayfor21days.Subsequently,thevariables weremeasuredinthehippocampus.Results: The findings revealed that the hippocampal CORT levels in the preventive exercise group had a significant enhancement compared to the control group. In the protective and particularly the therapeutic exercise groups, the hippocampal CORT levels declined. Furthermore,thehippocampalBDNFlevelsinthepreventiveandthetherapeuticexercisegroups indicated significantly decreased and increased, respectively, in comparison with the control group.Inthepreventiveexercisegroup,however,thehippocampalglucoselevelturnedouttobe substantiallyhigherthanthatinthecontrolgroup.Conclusion: Itappearsthatthetherapeuticexercisegrouphadthebestexerciseprotocols for improving the hippocampal memory mediators in the stress conditions. By contrast, the preventive exercise group could not improve these mediators that had been altered by stress. It is suggested that exercise time, compared to stress, can be considered as a crucial factor in the responsivenessofmemorymediators.