Restoring the Treg cell to Th17 cell ratio may alleviate HBV-related acute-on-chronic liver failure

Niu, Yinghua; Yin, Dong-Lin; Liu, Hongli; Yi, Ruitian; Yang, Ye; Xue, Hong-an; Chen, Tianyan; Zhang, Shulin; Su, Lin; Zhao, Yingren

doi:10.3748/wjg.v19.i26.4146

Cited by 28 publications

(27 citation statements)

References 34 publications

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“…In the mouse model of RSV infection, RSV‐induced immunopathology in the lung could be modulated by regulating the balance between Treg and Th17 cells . In HBV infection, restoration of the Treg/Th17 cell ratio was believed to be helpful for the maintenance of the immune homoeostasis and favouring good outcomes for patients with HBV‐related ACLF . Besides, the Treg/Th17 cell ratio can also be used as a potential marker for the prediction of the occurrence of decompensated liver cirrhosis .…”

Section: Discussionmentioning

confidence: 99%

Regulatory T cells and T helper 17 cells in viral infection

et al. 2020

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CD4 + T cells are the central element of the adaptive immune responses and protect the body from a variety of pathogens. Starting from naive cells, CD4 + T cells can differentiate into various effector cell subsets with specialized functions including T helper (Th) 1, Th2, Th17, regulatory T (Treg) and T follicular helper (Tfh) cells. Among them, Tregs and Th17 cells show a strong plasticity allowing the functional adaptation to various physiological and pathological environments during immune responses. Although they are derived from the same precursor cells and their differentiation pathways are interrelated, the terminally differentiated cells have totally opposite functions. Studies have shown that Tregs and Th17 cells have rather complex interplays in viral infection: Th17 cells may contribute to immune activation and disease progression while Tregs may inhibit this process and play a key role in the maintenance of immune homoeostasis, possibly at the cost of compromised viral control. In this review, we take respiratory syncytial virus (RSV), hepatitis B virus (HBV)/hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections as examples to discuss these interplays and their impacts on disease progression in viral infection. How to cite this article: Wan Z, Zhou Z, Liu Y, et al. Regulatory T cells and T helper 17 cells in viral infection. Scand J Immunol. 2020;91:e12873.

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Section: Discussionmentioning

confidence: 99%

Regulatory T cells and T helper 17 cells in viral infection

et al. 2020

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“…The Treg and Th17 cells participate in the progression of hepatic failure. Niu et al found that both circulating Treg and Th17 cell frequencies increased in hepatitis B virus- (HBV-) ACLF patients compared to the healthy ones [ 7 ]. However, others showed that the circulating Th17 cell proportion increased significantly and Treg cell changed without statistical significance [ 8 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model

Yang

et al. 2017

Mediators of Inflammation

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Aims. Acute-on-chronic liver failure (ACLF) and acute liver failure (ALF) are similar in many respects during their acute exacerbation; however, ACLF generally has a poorer prognosis. We aimed to investigate the role and dynamic changes of regulatory T cell (Treg) and T helper 17 (Th17) cell proportions during ACLF progress. Methods. All rats were classified into two groups randomly: ACLF group and ALF group (control group). The rat model of ACLF was preestablished by intraperitoneal injection of carbon tetrachloride for 2 months. Then acute liver injury was induced by combined D-galactosamine and lipopolysaccharide. Six time points were examined before or after acute induction. Liver samples were performed with hematoxylin-eosin and Masson staining; circulatory Treg and Th17 cell frequencies were determined using flow cytometry assays; serum levels of alanine aminotransferase, aspartate aminotransferase, interleukin-10 (IL-10), and interferon-γ (IFN-γ) were examined. Results. In group ACLF, both Th17 cell proportion and IFN-γ level presented upgrade firstly and then descend latter tendency; the trends of Treg cell proportion and IL-10 level were observed to gradually decrease and became stable. Conclusion. The Treg cells played an important role in the immunologic mechanism during the process of ACLF. And the function of Treg cells in ACLF was defective.

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“…Together with Th17 cells, regulatory T cells (Tregs) play a major role in human disease . Accordingly, recent reports suggest that controlling the balance between Tregs and Th17 cells may be a promising therapeutic strategy for inflammatory diseases . However, no data are present in the literature about Tregs in PG.…”

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confidence: 99%

The Treg/Th17 cell ratio is reduced in the skin lesions of patients with pyoderma gangrenosum

et al. 2015

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Restoring the Treg cell to Th17 cell ratio may alleviate HBV-related acute-on-chronic liver failure

Abstract: Restoring the Treg cell to Th17 cell ratio during the follow-up phase of ACLF could maintain the immune system at a steady state, which favours good prognosis.

Cited by 28 publications

References 34 publications

Regulatory T cells and T helper 17 cells in viral infection

Regulatory T cells and T helper 17 cells in viral infection

Deregulation of Regulatory T Cells in Acute-on-Chronic Liver Failure: A Rat Model

The Treg/Th17 cell ratio is reduced in the skin lesions of patients with pyoderma gangrenosum

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