Restoring Th17/Treg balance via modulation of STAT3 and STAT5 activation contributes to the amelioration of chronic obstructive pulmonary disease by Bufei Yishen formula

Zhao, Peng; Li, Jiansheng; Tian, Yange; Mao, Jiale; Liu, Xuefang; Shao, Feng; Li, Junzi; Bian, Qingqing; Ji, Huige; Zhang, Lanxi

doi:10.1016/j.jep.2018.02.023

Cited by 43 publications

(31 citation statements)

References 34 publications

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“…Cotreatment with KW6002 diminished the therapeutic effect of BYF on COPD. Previously, regulation of the Th17/Treg balance was shown to play a key role in the anti-COPD effect of BYF (Zhao et al, 2018). In this work, we also demonstrated that KW6002 reversed the decrease in the Th17 cell proportion, the increase in the Treg proportion, and changes in STAT3 and STAT5 phosphorylation and A2aR signaling induced by BYF in COPD rats.…”

Section: Discussionsupporting

confidence: 74%

“…We previously showed that BYF treatment ameliorated lung function and pathological changes in COPD rats ( Li et al., 2015 ; Li Y. et al., 2016 ), which was mainly attributed to the inhibition of inflammatory responses and regulation of the Th17/Treg cell balance ( Zhao et al., 2018 ). However, the mechanisms by which BYF mediates its anti-COPD effects remained unknown.…”

Section: Discussionmentioning

confidence: 99%

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Bufei Yishen Formula Restores Th17/Treg Balance and Attenuates Chronic Obstructive Pulmonary Disease via Activation of the Adenosine 2a Receptor

et al. 2020

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Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Bufei Yishen Formula Restores Th17/Treg Balance and Attenuates Chronic Obstructive Pulmonary Disease via Activation of the Adenosine 2a Receptor

et al. 2020

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“…During inflammation proinflammatory mediators are antagonized by anti-inflammatory cytokines [ 33 ]. Treg related interleukin-10 (IL-10), the anti-inflammatory cytokine inhibitory factor, antagonizes the action of the major inflammatory cytokines [ 34 , 35 ]. Studies showed that IL-10 level was decreased in COPD patients while healthy volunteers expressed higher level of IL-10 [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Baicalin Exerts Anti‐Airway Inflammation and Anti‐Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease

Genfa

Mohammadtursun

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Chronic obstructive pulmonary disease (COPD) is a worldwide epidemic. Current approaches are disappointing due to limited improvement of the disease development. The present study established 36-week side stream cigarette smoke induced rat model of COPD with advanced stage feature and evaluted the effects of baicalin on the model. Fifty-four Sprague–Dawley rats were randomly divided into six groups including room air control, cigarette smoke exposure, baicalin (40 mg/kg, 80 mg/kg, and 160 mg/kg), and budesonide used as a positive control. Rats were exposed to cigarette smoke from 3R4F research cigarettes. Pulmonary function was evaluated and pathological changes were also observed. Cytokine level related to airway inflammation and remodelling in blood serum, bronchoalveolar lavage fluid, and lung tissue was determined. Blood gases and HPA axis function were also examined, and antioxidant levels were quantified. Results showed that, after treatment with baicalin, lung function was improved and histopathological changes were ameliorated. Baicalin also regulated proinflammatory and anti-inflammatory balance and also airway remodelling and anti-airway remodelling factors in blood serum, bronchoalveolar lavage fluid, and lung tissue. Antioxidant capacity was also increased after treatment with baicalin in COPD rat model. HPA axis function was improved in baicalin treated groups as compared to model group. Therefore, baicalin exerts lung function protection, proinflammatory and anti-inflammatory cytokine regulation, anti-airway remodelling, and antioxidant role in long term CS induced COPD model.

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“…T cell-mediated adaptive immunity is deeply involved in the regulation of airway inflammation during COPD development 3 , 4 , and Th17 cells, a subset of activated CD4 + T cells, are associated with the progression and exacerbation of alveolar destruction via interleukin (IL)-17 release 3 – 7 . In contrast, regulatory T (Treg) cells are a T cell subtype that is responsible for maintaining immune homeostasis by inhibiting abnormal immune responses and suppressing inflammation 3 .…”

Section: Introductionmentioning

confidence: 99%

Th17/Treg imbalance in COPD development: suppressors of cytokine signaling and signal transducers and activators of transcription proteins

Silva

Lourenço

Silva

et al. 2020

Sci Rep

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Th17/Treg imbalance contributes to chronic obstructive pulmonary disease (COPD) development and progression. However, intracellular signaling by suppressor of cytokine signaling (SOCS) 1 and SOCS3 and the proteins signal transducer and activator of transcription (STAT) 3 and STAT5 that orchestrate these imbalances are currently poorly understood. Thus, these proteins were investigated in C57BL/6 mice after exposure to cigarette smoke (CS) for 3 and 6 months. The expression of interleukin was measured by ELISA and the density of positive cells in peribronchovascular areas was quantified by immunohistochemistry. We showed that exposure to CS in the 3rd month first induced decreases in the numbers of STAT5+ and pSTAT5+ cells and the expression levels of TGF-β and IL-10. The increases in the numbers of STAT3+ and pSTAT3+ cells and IL-17 expression occurred later (6th month). These findings corroborate the increases in the number of SOCS1+ cells in both the 3rd and 6th months, with concomitant decreases in SOCS3+ cells at the same time points. Our results demonstrated that beginning with the initiation of COPD development, there was a downregulation of the anti-inflammatory response mediated by SOCS and STAT proteins. These results highlight the importance of intracellular signaling in Th17/Treg imbalance and the identification of possible targets for future therapeutic approaches.

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Restoring Th17/Treg balance via modulation of STAT3 and STAT5 activation contributes to the amelioration of chronic obstructive pulmonary disease by Bufei Yishen formula

Cited by 43 publications

References 34 publications

Bufei Yishen Formula Restores Th17/Treg Balance and Attenuates Chronic Obstructive Pulmonary Disease via Activation of the Adenosine 2a Receptor

Bufei Yishen Formula Restores Th17/Treg Balance and Attenuates Chronic Obstructive Pulmonary Disease via Activation of the Adenosine 2a Receptor

Baicalin Exerts Anti‐Airway Inflammation and Anti‐Remodelling Effects in Severe Stage Rat Model of Chronic Obstructive Pulmonary Disease

Th17/Treg imbalance in COPD development: suppressors of cytokine signaling and signal transducers and activators of transcription proteins

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