Restoring apoptosis dysregulation using survivin inhibitor in nasopharyngeal cancer

Shi, Jin; Tan, Soo Yee; Lee, Andrea Zhe Ern; Zhang, Siting; Sasidharan, Swarnalatha Lucky; Wong, Benjamin; Tan, Min; Lim, Chwee Ming

doi:10.1002/hed.26068

Cited by 8 publications

(7 citation statements)

References 40 publications

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“…BIRC5 is highly expressed in a variety of tumor tissues, while its expression level is very low or not expressed in normal tissues. Some studies have con rmed that BIRC5 is involved in the malignant transformation of tumor cells and the physiological process of anti-apoptosis, suggesting that BIRC5 gene can be used as an important target for anti-tumor therapy [21]. In this study, BIRC5 expression in LGG normal tissues and tumor tissues was compared and analyzed.…”

Section: Discussionmentioning

confidence: 97%

Expression And Clinical Significance of BIRC5 In Low-Grade Gliomas Based On Bioinformatics Analysis

Yang

2021

Preprint

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Background: To screen target genes analyze the expression and mechanism of target genes in Low-grade Gliomas (LGG).Methods: LGG data were downloaded from TCGA database. Differentially expressed genes (DEGs) were screened by differential expression screening, protein–protein interaction (PPI) and enrichment analysis, and then the differentially immune related genes were obtained by analyzing DEGs and immune genes. The abundance of 22 leukocyte subtypes was calculated by CIBERSORT algorithm. The Hub gene constructed by PPI and the gene of prognosis model were analyzed to screen the LGG target gene. The correlation between target gene and LGG prognosis and clinical characteristics of LGG were analyzed. Results: After immunotherapy, the survival of high TMB group was significantly longer than that low TMB group, and the scores of TMB group were correlated with the age and grade of patients. PPI indicates that AURKA, BUB1, AURKB, CDC20, BIRC5, TTK, CCNB2, CDCA8, and CENPE are the hub genes of LGG. The expression level of BIRC5 in LGG tumor tissues was significantly higher than that in normal tissues. The expression level of BIRC5 was correlated with the age and grade of LGG patients. BIRC5 might participate in the occurrence and development of LGG through P53 pathway.Conclusion: BIRC5 can be used as LGG target gene, and its high expression in LGG indicates poor prognosis. BIRC5, as a therapeutic target of LGG, provides a new direction for immunotherapy of LGG.

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Section: Discussionmentioning

confidence: 97%

Expression And Clinical Significance of BIRC5 In Low-Grade Gliomas Based On Bioinformatics Analysis

Yang

2021

Preprint

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“…The NDC80 complex, including the main elements of NDC80, SPC24, and SPC25, is highly expressed in various tumors and cooperatively promotes the invasion and metastasis of tumor cells (Alushin et al, 2012;Umbreit et al, 2012). BIRC5 is a negative regulatory protein that inhibits tumor cell apoptosis and promotes cell proliferation (Cho et al, 2020;Shi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma

Jiang

Ke²,

et al. 2021

Front. Mol. Biosci.

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With high mortality and poor prognosis, hepatocellular carcinoma (LIHC) has become the fourth leading cause of cancer-related deaths worldwide. Most of the LIHC patients missed the best treatment period because of the untimely diagnosis. For others, even if they are temporarily cured, they have to face a very low prognostic survival rate and a very high risk of recurrence. Based on the characteristics of abnormal proliferation and uncontrolled growth of tumor cells. Cell Division Cycle Associated (CDCA) family genes, which are responsible for regulating the cell cycle and proliferation, were selected as our research object to explore the mechanism of hepatocarcinogenesis. To this end, we investigated the expression profiles of CDCA family genes in LIHC and corresponding normal tissues, and the effect of CDCAs expression on the survival of prognosis and immune cell infiltration through bioinformatics analysis methods and the publicly accessible online databases. In addition, we also analyzed the expression correlation of CDCAs and screened the neighboring genes related to functional CDCAs. The results revealed that the expression levels of CDCA1/3/5/8 were significantly increased in LIHC, regardless of stage, sex, race, drinking behavior, and other clinical factors. CDCAs expression was significantly correlated with poor prognosis and was positively correlated with the infiltration of dendritic cells, B cells, and macrophages. We also found that the most relevant neighboring genes to CDCAs in LIHC were SGO2, NDC80, BIRC5, INCENP, and PLOD1. In general, our work suggests that CDCA1/3/5/8 has the potential to be a diagnostic gene in hepatocarcinogenesis and prognostic biomarkers for LIHC patients.

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“…It has been reported that anti-survivin siRNA enhances apoptosis and overcomes chemotherapy resistance in vitro [59] and in vivo [60]. In NPC, Shi et al reported that the YM-155, which is a survivin inhibitor, induces apoptosis of NPC cells and inhibits tumor growth in the mouse model [61]. Apart from the inhibition of apoptosis, cell proliferation is also related to survivin.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Survivin in Nasopharyngeal Carcinoma: A Systematic Review and Meta-analysis

Xie¹,

Yan²,

Li³

et al. 2021

J. Cancer

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Background: Previous studies have shown that survivin has potential prognostic value in nasopharyngeal carcinoma. However, the results remained controversial until now. Thus, to investigate the influence of survivin expression on prognosis and clinical characteristics in nasopharyngeal carcinoma, we performed this meta-analysis. Methods: We searched PubMed, PMC, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure electronic databases from their establishment to 1 March 2021. The pooled hazard ratio (HR) and the pooled odds ratio (OR) were used to evaluate the prognostic and clinicopathological values of survivin in nasopharyngeal carcinoma. We used the I 2 statistic and the Q test to evaluate heterogeneity. Meta-regression, publication bias, and sensitivity analyses were also conducted. Results: A total of 26 eligible studies with 2278 patients were included in our meta-analysis. We found that the expression of survivin is connected with poor overall survival (HR=1.94; 95% confidence interval (CI)=1.

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Restoring apoptosis dysregulation using survivin inhibitor in nasopharyngeal cancer

Cited by 8 publications

References 40 publications

Expression And Clinical Significance of BIRC5 In Low-Grade Gliomas Based On Bioinformatics Analysis

Expression And Clinical Significance of BIRC5 In Low-Grade Gliomas Based On Bioinformatics Analysis

Cell Division Cycle Associated Genes as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma

Prognostic Value of Survivin in Nasopharyngeal Carcinoma: A Systematic Review and Meta-analysis

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