Restoration of the interfacial properties of lung surfactant with a newly designed hydrocarbon/fluorocarbon lipid

Dilli, Gokce; Unsal, Hande; Uslu, Burcin; Aydoğan, Nihal

doi:10.1016/j.colsurfb.2014.07.034

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Animals Experience a Range Of Adverse Effects Usually At Hi1

Fluorinated Surfactants In Combination With Dppc Provide Mix...1

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Cited by 5 publications

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“…Fluorocarbons and F-surfactants have been shown to readily penetrate phospholipid films and bilayer membranes, and alter their phase behavior and properties [245][246][247][248]. Fluorocarbons can actually act as lung surfactant substitutes [249].…”

Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 98%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

227

122

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Section: Animals Experience a Range Of Adverse Effects Usually At Himentioning

confidence: 98%

Per- and polyfluorinated substances (PFASs): Environmental challenges

Krafft

Riess²

2015

Current Opinion in Colloid & Interface Science

227

122

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“…[125][126][127][128][129][130][131] Addition of the partially fluorinated (perfluorooctyl)pentanol (C 8 F 17 C 5 H 10 OH) to DPPC-Hel 13-5 peptide mixtures yielded significant enhancement of surfactant recovery when submitted to repeated compressionexpansion cycles, and allowed reaching very low surface tension values upon film compression (Table 1). 132 A mixed fluorocarbon-hydrocarbon ion pair compound (C 8 F 17 SO 3 À (C 2 H 5 ) 3 N + (CH 2 OCH 2 ) 10 C 16 H 33 ) was shown to reduce the inhibitory effect of fibrinogen by selectively interacting with DPPC and mimicking some of the surface properties of SP-C. 133,134 In particular, it was found that fibrinogen could not penetrate in DPPC monolayers formed in the presence of this partially fluorinated compound.…”

Section: Fluorinated Surfactants In Combination With Dppc Provide Mix...mentioning

confidence: 99%

Overcoming inactivation of the lung surfactant by serum proteins: a potential role for fluorocarbons?

Krafft

2015

Soft Matter

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In many pulmonary conditions serum proteins interfere with the normal adsorption of components of the lung surfactant to the surface of the alveoli, resulting in lung surfactant inactivation, with potentially serious untoward consequences. Here, we review the strategies that have recently been designed in order to counteract the biophysical mechanisms of inactivation of the surfactant. One approach includes protein analogues or peptides that mimic the native proteins responsible for innate resistance to inactivation. Another perspective uses water-soluble additives, such as electrolytes and hydrophilic polymers that are prone to enhance adsorption of phospholipids. An alternative, more recent approach consists of using fluorocarbons, that is, highly hydrophobic inert compounds that were investigated for partial liquid ventilation, that modify interfacial properties and can act as carriers of exogenous lung surfactant. The latter approach that allows fluidisation of phospholipid monolayers while maintaining capacity to reach near-zero surface tension definitely warrants further investigation.

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