New experimental model of pulmonary surfactant for biophysical studies

Sosnowski, Tomasz R.; Kubski, Paweł; Wojciechowski, Kamil

doi:10.1016/j.colsurfa.2016.06.044

Cited by 34 publications

(24 citation statements)

References 50 publications

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“…The complexity of the lung surfactant system makes it difficult to study the particles' impact in their performance using in vivo assays, which imposes the use of simple physico-chemical models for helping in the understanding of the potential toxicity of inhaled particles [20,24]. Thus, considering that the performance of lung surfactant is associated with their adsorption as a thin film at the interfacial region existing between the alveolar fluid overlaying the alveolar inner wall and the air contained in alveoli, the Langmuir monolayer at water/vapor interfaces may be considered as a useful tool for deepening the physico-chemical bases underlying the mechanical function of the lung surfactant layer, and the impact of the incorporation of nanoparticles on its performance [20,21,24]. Furthermore, the chemical complexity of lung surfactant makes it necessary to reduce the number of chemical species included in the used model to deepen the role of each single component in the interfacial properties of the lung surfactant layer and to understand how nanoparticles modify its performance.…”

Section: Introductionmentioning

confidence: 99%

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

et al. 2020

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Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle.

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Section: Introductionmentioning

confidence: 99%

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

et al. 2020

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“…The area exposed to the air reduced due to γ which subsequently reduces the area accessible for gaseous exchange. [ 9 , 10 , 11 ].…”

Section: Biophysical Role Of Pulmonary Surfactantmentioning

confidence: 99%

Exogenous pulmonary surfactant: A review focused on adjunctive therapy for severe acute respiratory syndrome coronavirus 2 including SP-A and SP-D as added clinical marker

Ghati¹,

Dam

Tasdemir

et al. 2021

Current Opinion in Colloid & Interface Science

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Type I and Type II pneumocytes are two forms of epithelial cells found lining the alveoli in the lungs. Type II pneumocytes exclusively secrete ‘pulmonary surfactants’, a lipo-protein complex made up of 90% lipids (mainly phospholipids) and 10% surfactant proteins (SP-A, SP-B, SP-C, and SP-D). Respiratory diseases like influenza, SARS-CoV and SARS-CoV-2 are reported to preferentially attack type II pneumocytes of the lungs. After viral invasion, consequent viral propagation and destruction of type II pneumocytes causes altered surfactant production, resulting in dyspnea and Acute respiratory distress syndrome (ARDS) in COVID-19 patients. Exogenous animal-derived or synthetic pulmonary surfactant therapy has already shown immense success in the treatment of neonatal respiratory distress syndrome (RDS) and has the potential to contribute efficiently to repairing damaged alveoli and preventing SARS-CoV-2-associated respiratory failure. Furthermore, the early detection of surfactant collectins (SP-A and SP-D) in the circulatory system can be a significant clinical marker for disease prognosis in the near future.

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“…Saponins exhibit a wide range of biological activities, such as hypocholesterolemic, hypoglycemic, hepatoprotective, hemolytic, immunomodulatory, antiviral, anti-inflammatory and antitumor activities [ 15 , 16 ]. Many of these activities are usually associated with the interactions of saponins with the lipids of biological membranes, such as cholesterol and phospholipids [ 37 , 38 , 39 , 40 , 41 , 42 ]. Numerous studies have demonstrated the ability of saponins to inhibit cholesterol absorption and to decrease serum and liver cholesterol [ 43 , 44 ].…”

Section: Biological Activities Of Saponinsmentioning

confidence: 99%

“…As one of the most common saponins, Quillaja saponins (QS) are known to interact with biological membranes, and the model DPPC monolayer studies showed that they can effectively penetrate phospholipid mono- and bilayers and, meanwhile, do not disrupt DPPC monolayers [ 39 ]. Sosnowski et al found that QS may be useful in biophysical studies related to pulmonary surfactant dynamics, since it has the ability of enhancing the phospholipid mass exchange between the interface and the liquid subphase [ 42 ]. Previous studies have shown that saponins (e.g., QS) can be wrapped by neutral phospholipids and cholesterol as an immunostimulating complex (ISCOM), which can effectively enhance humoral and cellular immune responses [ 45 , 46 ] and thus make the saponins have the ability to be used as appropriate vaccine adjuvants.…”

Section: Biological Activities Of Saponinsmentioning

confidence: 99%

Recent Advances and Applications of Plant-Based Bioactive Saponins in Colloidal Multiphase Food Systems

2021

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The naturally occurring saponins exhibit remarkable interfacial activity and also possess many biological activities linking to human health benefits, which make them particularly attractive as bifunctional building blocks for formulation of colloidal multiphase food systems. This review focuses on two commonly used food-grade saponins, Quillaja saponins (QS) and glycyrrhizic acid (GA), with the aim of clarifying the relationship between the structural features of saponin molecules and their subsequent self-assembly and interfacial properties. The recent applications of these two saponins in various colloidal multiphase systems, including liquid emulsions, gel emulsions, aqueous foams and complex emulsion foams, are then discussed. A particular emphasis is on the unique use of GA and GA nanofibrils as sole stabilizers for fabricating various multiphase food systems with many advanced qualities including simplicity, ultrastability, stimulability, structural viscoelasticity and processability. These natural saponin and saponin-based colloids are expected to be used as sustainable, plant-based ingredients for designing future foods, cosmetics and pharmaceuticals.

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New experimental model of pulmonary surfactant for biophysical studies

Cited by 34 publications

References 50 publications

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

Exogenous pulmonary surfactant: A review focused on adjunctive therapy for severe acute respiratory syndrome coronavirus 2 including SP-A and SP-D as added clinical marker

Recent Advances and Applications of Plant-Based Bioactive Saponins in Colloidal Multiphase Food Systems

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