Restoration of Reproductive Potential after Autotransplantation of Frozen Ovaries in Mice Pretreated with Cyclophosphamide

Transplantation of mouse ovarian tissue: Comparison of the transplantation sites

“…In previous reports, several heterotopic sites for OTT have been investigated, including the back muscle (BM) [10,11], fat pad (FP) [12,13], kidney capsule (KC) [14,15], and subcutaneous (SC) tissue [16,17]. Soleimani et al [18] recently found that the BM had some advantages as a mouse grafting site because of its angiogenic conditions.…”

“…The FP site is usually used when cancer cells are injected into mice because of the good blood supply and the small changes in temperature and pressure. Lee et al [12] reported that transplantation of vitrified-warmed mouse OT to the FP site was a useful procedure for fertility preservation. However, OTs transplanted into the FP site can be less functional and have increased risk of hemorrhage [13].…”