Restoration of Neuronal Plasticity by a Phosphodiesterase Type 1 Inhibitor in a Model of Fetal Alcohol Exposure

Medina, Alexandre E.; Krahe, Thomas E.; Ramoa, Ary S.

doi:10.1523/jneurosci.4177-05.2006

Cited by 54 publications

(60 citation statements)

References 18 publications

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“…ABT-239 did not, however, enhance LTP in control animals. The data from another group of investigators show that Vinpocetine facilitated plasticity of the sensory system in alcohol-affected animals (Krahe et al 2009;Medina and Krahe 2008;Medina et al 2006).…”

Section: Cognition-enhancing Drugsmentioning

confidence: 98%

From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders

Kodituwakku

2011

Neuropsychol Rev

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Since fetal alcohol syndrome was first described over 35 years ago, considerable progress has been made in the delineation of the neurocognitive profile in children with prenatal alcohol exposure. Preclinical investigators have made impressive strides in elucidating the mechanisms of alcohol teratogenesis and in testing the effectiveness of pharmacological agents and dietary supplementation in the amelioration of alcohol-induced deficits. Despite these advances, only limited progress has been made in the development of evidence-based comprehensive interventions for functional impairment in alcohol-exposed children. Having performed a search in PubMed and PsycINFO using key words, interventions, treatment, fetal alcohol syndrome, prenatal alcohol exposure, and fetal alcohol spectrum disorders, we found only 12 papers on empirically-based interventions. Only two of these interventions had been replicated and none met the criteria of "well-established," as defined by Chambless and Hollon (Journal of Consulting and Clinical Psychology 66(1):7-18, 1998). There has been only limited cross-fertilization of ideas between preclinical and clinical research with regard to the development of interventions. Therefore, we propose a framework that allows integrating data from preclinical and clinical investigations to develop comprehensive intervention programs for children with fetal alcohol spectrum disorders. This framework underscores the importance of multi-level evaluations and interventions.

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Section: Cognition-enhancing Drugsmentioning

confidence: 98%

From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders

Kodituwakku

2011

Neuropsychol Rev

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“…The same group has gone on to also implicate distinct alterations in cerebral cortical and striatal interneuron distribution and morphology Granato, 2006). Rodent postnatal alcohol exposure also leads to a persistent disruption in ocular dominance plasticity, which can be treated, at least in part, with overexpression of serum response factor or inhibition of a phosphodiesterase (Medina et al, 2006;Paul et al, 2010). Once again, these time periods are most similar to late prenatal development in humans (Figure 1).…”

Section: Alcoholmentioning

confidence: 99%

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Ross

Graham

Money

et al. 2014

Neuropsychopharmacol

315

241

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Most drugs of abuse easily cross the placenta and can affect fetal brain development. In utero exposures to drugs thus can have long-lasting implications for brain structure and function. These effects on the developing nervous system, before homeostatic regulatory mechanisms are properly calibrated, often differ from their effects on mature systems. In this review, we describe current knowledge on how alcohol, nicotine, cocaine, amphetamine, Ecstasy, and opiates (among other drugs) produce alterations in neurodevelopmental trajectory. We focus both on animal models and available clinical and imaging data from cross-sectional and longitudinal human studies. Early studies of fetal exposures focused on classic teratological methods that are insufficient for revealing more subtle effects that are nevertheless very behaviorally relevant. Modern mechanistic approaches have informed us greatly as to how to potentially ameliorate the induced deficits in brain formation and function, but conclude that better delineation of sensitive periods, dose-response relationships, and long-term longitudinal studies assessing future risk of offspring to exhibit learning disabilities, mental health disorders, and limited neural adaptations are crucial to limit the societal impact of these exposures.

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“…Among the changes in visual perception associated with alcohol use, we highlight: (i) neurodegenerative alterations in visual pathways and retinal layers integrated into the functional decline of rods and cones (Lima et al 2006); (ii) alterations in cortical receptive fields of single cells and hypercomplex selective visual spatial orientation (Medina, Krahe, & Ramoa, 2005); and (iii) alterations in visual processing of chromatic and achromatic stimuli (Castro et al 2009;Chen, Xia, Li, & Zhou, 2010;Rosenbloom et al, 2004;Wegner, Günthner, & Fahle, 2001).…”

Section: Introductionmentioning

confidence: 99%

Effects of chronic alcoholism in the sensitivity to luminance contrast in vertical sinusoidal gratings

Cruz

Andrade

Cavalcanti-Gaudino

et al. 2016

Psicol. Refl. Crít.

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The aim of this study was to measure visual contrast sensitivity (CS) of luminance using vertical sinusoidal gratings with spatial frequencies of 0.6, 2.5, 5.0 and 20.0 cycles per degree of visual angle in chronic alcoholics in abstinence period. The participants were 20 volunteers (26-59 years of age) divided into two groups: the study group (SG) consisted of 10 volunteers with a clinical history of chronic alcoholism abstinence and the control group (CG) consisted of 10 healthy volunteers. Each group had five female and five male participants. All participants had normal or corrected visual acuity and were free of identifiable diseases. The psychophysical method of forced choice between two temporal alternatives (2AFC) was used to measure visual CS of luminance of 41.2 cd/m 2 . The results showed significant differences between groups for all spatial frequencies tested (p < 0.001). These results suggest alterations in the visual perception related to chronic alcohol consumption even after years of abstinence.

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Restoration of Neuronal Plasticity by a Phosphodiesterase Type 1 Inhibitor in a Model of Fetal Alcohol Exposure

Cited by 54 publications

References 18 publications

From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders

From Research to Practice: An Integrative Framework for the Development of Interventions for Children with Fetal Alcohol Spectrum Disorders

Developmental Consequences of Fetal Exposure to Drugs: What We Know and What We Still Must Learn

Effects of chronic alcoholism in the sensitivity to luminance contrast in vertical sinusoidal gratings

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