Restoration of miR-143 reduces migration and proliferation of bladder cancer cells by regulating signaling pathways involved in EMT

Asghariazar, Vahid; Kadkhodayi, Mahtab; Mansoori, Behzad; Mohammadi, Ali; Baradaran, Behzad

doi:10.1016/j.mcp.2022.101794

Cited by 14 publications

(6 citation statements)

References 50 publications

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“…Several miRNAs, such as miR-192, miR-194, miR-215, miR-221, miR-509-5p, miR-944, miR-1305, miR-585, miR-548b-3p, miR-219a-2-3p, miR-518, miR-143 and miR-3928, have been studied for their ability to target the MDM2 gene. These analyses concerned various malignancies, such as multiple myeloma, hepatocellular carcinoma, pancreatic cancer, colorectal cancer, non-small cell lung cancer, glioma, breast cancer, pituitary adenoma, gastric carcinoma and bladder cancer [15,[55][56][57][58][59][60][61][62][63][64]. Our study found no evidence that miR-3613-3p, miR-371b-5p and miR-3658 regulated MDM2 gene expression in OSCC samples.…”

Section: Discussionmentioning

confidence: 61%

The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma

Gołąbek,

Hudy,

Gaździcka

et al. 2023

Biomedicines

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MiRNAs could play an important role in tumorigenesis and progression. The oncoprotein MDM2 (murine double minute 2) was identified as a negative regulator of the tumour suppressor p53. This study aims to analyse the expression of the MDM2 target miRNA candidates (miR-3613-3p, miR-371b-5p and miR-3658) and the MDM2 gene in oral squamous cell carcinoma tumour and margin samples and their association with the selected socio-demographic and clinicopathological characteristics. The study group consisted of 50 patients. The miRNAs and MDM2 gene expression levels were assessed by qPCR. The expression analysis of the miRNAs showed the expression of only one of them, i.e., miR-3613-3p. We found no statistically significant differences in the miR-3613-3p expression in tumour samples compared to the margin samples. When analysing the effect of smoking on miR-3613-3p expression, we demonstrated a statistically significant difference between smokers and non-smokers. In addition, we showed an association between the miR-3613-3p expression level and some clinical parameters in tumour samples (T, N and G). Our study demonstrates that miR-3613-3p overexpression is involved in the tumour progression of OSCC. This indicates that miR-3613-3p possesses potential prognostic values.

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Section: Discussionmentioning

confidence: 61%

The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma

Gołąbek,

Hudy,

Gaździcka

et al. 2023

Biomedicines

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“…In brief, after cultivation of 4×105 cells per well in a 6-well plate, breast cancer cells were treated with 50 µg/mL dose of MnO 2 @Poly(DMAEMA-Co-IA) NPs and MTX for 24h. Additionally, radiation groups were exposed to 8 Gy of absorbed radiation from 6 MV radiation beams (at a dosage rate of 300 MU/min The following step involved staining the collected cells with Annexin V-FITC and Propidium Iodide (IQ products, Netherlands).After 15 minutes, the ratio of apoptotic cells was de ned by a ow cytometer (Partec CyFlow®) [30].…”

Section: Apoptosis Assaymentioning

confidence: 99%

Preparation of MnO2@poly-(DMAEMA-co-IA)-conjugated methotrexate nano-complex for MRI and radiotherapy of breast cancer application

Ziyaee

Malekzadeh

Ghorbani

et al. 2023

Magn Reson Mater Phy

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A novel e cient pH-sensitive targeted magnetic resonance imaging (MRI) contrast agent and innovative radiosensitizing system were synthesized based on MnO 2 NPs coated with biocompatible poly (dimethylaminoethyl methacrylate -Co-itaconic acid) and targeted with methotrexate. The established NPs were characterized and MRI signal enhancement, relaxivity, cell targeting, toxicity, and radiotherapy e cacy were evaluated.The developed system displayed pH-responsive MRI contrast enhancement, differential uptake in malignant and normal cells, negligible in vitro cytotoxicity, and suitable in vitro cell targeting ability.Enhanced therapeutic e cacy in hypoxic conditions con rmed the e ciency of the system in MR imaging and radiation therapy of hypoxia cells.

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“…Noncoding RNAs target E3 ubiquitin ligases to control bladder cancer initiation and progression. For example, miR-143 inhibited the expression of MDM2 and performed a tumor suppressive function via inhibition of cell growth and migration in bladder cancer (150). LncRNA SNHG1 sponged miR-9-3p expression and upregulated the expression of MDM2 in bladder cancer cells.…”

Section: Noncoding Rnas Target E3 Ligasesmentioning

confidence: 99%

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

Wang

Zhang

et al. 2023

Front. Immunol.

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Bladder cancer is one of the common malignant urothelial tumors. Post-translational modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation, have been revealed to participate in bladder cancer initiation and progression. Ubiquitination is the common PTM, which is conducted by E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme and E3 ubiquitin-protein ligase. E3 ubiquitin ligases play a key role in bladder oncogenesis and progression and drug resistance in bladder cancer. Therefore, in this review, we summarize current knowledge regarding the functions of E3 ubiquitin ligases in bladder cancer development. Moreover, we provide the evidence of E3 ubiquitin ligases in regulation of immunotherapy in bladder cancer. Furthermore, we mention the multiple compounds that target E3 ubiquitin ligases to improve the therapy efficacy of bladder cancer. We hope our review can stimulate researchers and clinicians to investigate whether and how targeting E3 ubiquitin ligases acts a novel strategy for bladder cancer therapy.

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Restoration of miR-143 reduces migration and proliferation of bladder cancer cells by regulating signaling pathways involved in EMT

Cited by 14 publications

References 50 publications

The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma

The Analysis of Selected miRNAs and Target MDM2 Gene Expression in Oral Squamous Cell Carcinoma

Preparation of MnO2@poly-(DMAEMA-co-IA)-conjugated methotrexate nano-complex for MRI and radiotherapy of breast cancer application

The role of E3 ubiquitin ligases and deubiquitinases in bladder cancer development and immunotherapy

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