A novel e cient pH-sensitive targeted magnetic resonance imaging (MRI) contrast agent and innovative radiosensitizing system were synthesized based on MnO 2 NPs coated with biocompatible poly (dimethylaminoethyl methacrylate -Co-itaconic acid) and targeted with methotrexate. The established NPs were characterized and MRI signal enhancement, relaxivity, cell targeting, toxicity, and radiotherapy e cacy were evaluated.The developed system displayed pH-responsive MRI contrast enhancement, differential uptake in malignant and normal cells, negligible in vitro cytotoxicity, and suitable in vitro cell targeting ability.Enhanced therapeutic e cacy in hypoxic conditions con rmed the e ciency of the system in MR imaging and radiation therapy of hypoxia cells.
A novel efficient pH-sensitive targeted magnetic resonance imaging (MRI) contrast agent and innovative radiosensitizing system were synthesized based on MnO2 NPs coated with biocompatible poly (dimethylaminoethyl methacrylate -Co- itaconic acid) and targeted with methotrexate. The established NPs were characterized and MRI signal enhancement, relaxivity, cell targeting, toxicity, and radiotherapy efficacy were evaluated. The developed system displayed pH-responsive MRI contrast enhancement, differential uptake in malignant and normal cells, negligible in vitro cytotoxicity, and suitable in vitro cell targeting ability. Enhanced therapeutic efficacy in hypoxic conditions confirmed the efficiency of the system in MR imaging and radiation therapy of hypoxia cells.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.