Restoration of Memory and Acetylcholinesterase Activity by Michelia Champaca in Chronically Noise Stressed Wistar Albino Rats

Abstract

Objective: The ability of an organism to adapt to aversive stressful situations or life challenging circumstances is very crucial to its state of health and survival. However, the breakdown in adaptation due to persistent uncontrollable stress leads to impairment of bodily functions and the onset of a variety of pathological disorders, especially memory decline. This study was designed to evaluate the effect of Michelia champaca a potent antioxidant on chronic noise-stress-induced memory impairment in rats.Methods: Male Wistar albino rats were used in this study. Animals were exposed to noise for 30 consecutive days (4 hrs/day) before testing for memory. Thereafter, the plasma corticosterone level and acetylcholinesterase (AchE) activity were estimated in the three discrete regions of the brain homogenate using a spectrophotometer. Result:Our results showed that M. champaca prevented memory impairment and suppressed corticosterone concentrations induced by chronic noise stress. Moreover, it also decreased brain AchE activity when compared with the chronic stress group (p<0.05). Conclusions:These findings suggest that M. champaca attenuates memory deficits induced by chronic noise stress in albino rats and may be useful therapeutically for stress-related cognitive dysfunctions. The reduction in the levels of serum corticosterone and inhibition of cholinesterase enzyme might be contributing significantly to the positive effect of M. champaca on memory in rats exposed to chronic noise stress.

Stress Response of Neurotransmitters and Micro-RNAs 34c and 7a in Serum and Hypothalamus of Rats after Exposure to Different Powers of Noise

“…There are numerous processes that take place in between a stressful input and the body's ensuing reactions. Both the central and autonomic nervous systems are involved in a range of neurochemical reactions throughout these activities (36) . The result of the present research showed that noise exposure for four hours per day for 15 days at increasing intensities of 85 dB, 100 dB and 135 dB caused significant reduction in the levels of serum dopamine and serotonin in contrast to the control group.…”