Objective: To identify the memory enhancing role of Michelia champaca in acute noise stressed animals.
Methods:Male Wistar albino rats were used in this study. Animals were exposed to noise for 4 h before testing for memory. Thereafter, the plasma corticosterone level and acetylcholinesterase activity were estimated in the discrete regions of the brain, and the memory related behavior were assessed by eight arm radial maze.
Results:Our results showed that Michelia champaca enhances the memory activity and decreases the corticosterone concentrations in acute noise stress animals treated with M. champaca. Moreover, it also decreased brain acetylcholinesterase activity when compared with the acute stress group (p<0.05). Furthermore, behavioral tests indicate that working memory, is enhanced by acute stress and decreases the error levels in all the parameters studied in the behavior aspects when compared to control animals.
Conclusion:These findings suggest that Michelia champaca enhances the memory in albino rats and might be useful therapeutically for cognitive related dysfunctions. This could be due to the presence of memory boosting compounds and its antistressor and anti-acetylcholinesterase activity, thereby reduces the levels of serum corticosterone and inhibition of cholinesterase enzyme significantly.
Akika is one drug which has been used since olden days. In the time of Sindhu civilization Akika was in use, because it has been unearthed in Harappa Mohenjo-Daro 18 . It is one of the gem grouped under the uparatna varga (semi-precious group). In English it is known as Agate (chalcedony) which is having composition of silicon and oxygen with an infinite three-dimensional polymeric structure. Since it is having properties like sheeta (cold), hridya (cardio protective) and hridya prabhava (special action) the bhasma of Akika and pishti are indicated in palpitation and cardiac related diseases and in the field of Ayurveda practice it is a leading remedies for the same but because of its scattered references in Ayurveda many people have misconceptions that Akika belongs to Unani system of medicine which is not true. Hence the present article aims to review regarding origin, occurrence, purification, marana and pishtikarana of Akika from Ayurveda literary.
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