Restoration of acetylcholinesterase activity by<i>Euphorbia hirta</i>in discrete brain regions of chronically stressed rats

Anuradha, H V; Srikumar, B.N.; Deepti, N.; Rao, B.S. Shankaranarayana; Lakshmana, Madepalli K.

doi:10.3109/13880200903188534

Cited by 18 publications

(12 citation statements)

References 32 publications

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“…After the addition of the substrate acetylthiocholine iodide (0.075 M), change in the absorbance was noted every 2 min for 10 min at 412 nm via a spectrophotometer. The activity was expressed as micromoles hydrolyzed per minute per gram of tissue (Shankaranarayana Rao et al, ; Srikumar et al, ; Anuradha et al, ; Bhagya et al, ).…”

Section: Methodsmentioning

confidence: 99%

The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression

Bhagya

Srikumar

Raju

et al. 2014

J of Neuroscience Research

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Depression is a major psychiatric illness that is associated with cognitive dysfunctions. The underlying mechanism of depression-associated memory impairment is unclear. Previously, we showed altered hippocampal synaptic plasticity in an animal model of depression. Although several antidepressants are beneficial in the treatment of depression, very little is known about the effects of these drugs on depression-associated learning and memory deficits. Prolonged antidepressant treatment might contribute to neuroplastic changes required for clinical outcomes. Accordingly, we evaluated the effect of chronic reboxetine (a selective noradrenergic reuptake inhibitor) treatment on depression-induced reduced hippocampal synaptic plasticity, neurotransmitter levels, and spatial learning and memory impairments. Depression was induced in male Wistar rats by the administration of clomipramine from postnatal days 8 to 21, and these rats were treated with reboxetine in adulthood. The neonatal clomipramine administration resulted in impaired hippocampal long-term potentiation (LTP), decreased hippocampal cholinergic activity and monoamine levels, and poor performance in a partially baited eight-arm radial maze task. Chronic reboxetine treatment restored the hippocampal LTP, acetylcholinesterase activity, and levels of biogenic amines and ameliorated spatial learning and memory deficits in the depressed state. Thus, restoration of hippocampal synaptic plasticity might be a cellular mechanism underlying the beneficial effect of reboxetine in depression-associated cognitive deficits. This study furthers the existing understanding of the effects of antidepressants on learning, memory, and synaptic plasticity and could ultimately assist in the development of better therapeutic strategies to treat depression and associated cognitive impairments.

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Section: Methodsmentioning

confidence: 99%

The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression

Bhagya

Srikumar

Raju

et al. 2014

J of Neuroscience Research

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show abstract

“…After the addition of the substrate acetylthiocholine iodide (0.075 M), change in the absorbance was noted every 2 min for 10 min at 412 nm using a spectrophotometer. The activity was expressed as micromoles hydrolyzed per minute per gram of tissue (Anuradha et al 2010;Shankaranarayana Rao et al 1998;Srikumar et al 2006). …”

Section: Estimation Of Monoamines Levelsmentioning

confidence: 99%

Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression

et al. 2010

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“…Acetylcholine and the cholinergic system are also known to involve in anxiety. Further study showed that anxiolytic effects of E. hirta in rats subjected to CIS was due to suppression of CIS-induced AChE activity in the frontal cortex, hippocampus, and septum brain regions (Anuradha et al, 2010). Together with GABAmimic effect and AChE reducing effect may explain the anxiolytic activity of E. hirta.…”

Section: Effects Of E Hirta On Anti-anxietymentioning

confidence: 86%

Potential Applications of Euphorbia hirta in Pharmacology

Shih¹,

Cherng²

2012

Drug Discovery Research in Pharmacognosy

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Restoration of acetylcholinesterase activity byEuphorbia hirtain discrete brain regions of chronically stressed rats

Cited by 18 publications

References 32 publications

The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression

The selective noradrenergic reuptake inhibitor reboxetine restores spatial learning deficits, biochemical changes, and hippocampal synaptic plasticity in an animal model of depression

Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression

Potential Applications of Euphorbia hirta in Pharmacology

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