Potential Applications of Euphorbia hirta in Pharmacology

Shih, Mei‐Fen; Cherng, Jong Yuh

doi:10.5772/34644

Cited by 3 publications

(1 citation statement)

References 56 publications

(56 reference statements)

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“…Secara tradisional, herba patikan kebo banyak digunakan untuk mengatasi beberapa penyakit salah satunya hipertensi dengan mekanisme diuretik [12]. Analisis fitokimia yang ditelah dilakukan mengungkapkan bahwa tanaman ini memiliki kandungan gula perduksi, alkaloid, flavonoid, sterol, tannin dan triterpenoid [13] . Penyakit hipertensi dikaitkan dengan adanya proses peradangan dan keterkaitan stress oksidatif serta disfungsi endotel, sehingga peran obat-obat antiinflamasi dan senyawa dengan aktivitas antioksidan yang tinggi memiliki peran dalam penataalaksanaan penyakit ini [14].…”

Section: Prediksi Tanaman Terbaikunclassified

Analisis Graph Mining dalam Penentuan Senyawa Dan Tanaman Obat Indonesia Sebagai Antihipertensi

Setiani

Ardiansyah²,

Saepulrohman³

et al. 2022

JIIKM

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Hypertension, also known as high blood pressure, is a degenerative disease whose prevalence tends to increase every year. People in Indonesia generally treat this disease by using a mixture of several types of herbal plants or so-called herbs. This study aims to find out the potential of compounds and plants that have effectiveness as antihypertensives by combining the concept of multicomponent-multi-target with a bioinformatics approach. This study aims to find out the potential of compounds and medicinal plants in Indonesia that have effectiveness as antihypertensives using graph mining analysis. Graph tracing techniques can be applied to search for compounds and plants related to target proteins in a disease. Patikan kebo (Euphorbia factor Ti2, betaAmyrin, alpha-Amyrin), mango (3-Carene, L-Histidine), cayenne pepper (Capsanthin, Capsorubin, Solasonine), papaya (L-Histidine, Sterol, Caffeine), and fenugreek ( L-Histidine) is the best plant that acts as an antihypertensive agent by targeting 4 proteins or about 80% of the total 5 significant proteins in hypertension.

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Section: Prediksi Tanaman Terbaikunclassified

Analisis Graph Mining dalam Penentuan Senyawa Dan Tanaman Obat Indonesia Sebagai Antihipertensi

Setiani

Ardiansyah²,

Saepulrohman³

et al. 2022

JIIKM

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Effect Of <i>Euphorbia Cyparissias</i> Ointments On Acanthosis

Cristina

Dumitrescu²,

Brezovan³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

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Background: A pharmaco-chemical investigation of the Euphorbia cyparissias plant was justified by its known multiple therapeutic valences. Numerous components from extracts and latex of Euphorbiacae were identified, revealing a large plant family with a polyvalent therapeutic activity. Materials and Methods:The aim of the study was to assess the skin tolerance level to irritation on different testing concentrations, of Euphorbia cyparissias extracts and ointments. Study was accomplished in rats and dogs, with the identification of all possible skin injuries and histological changes, after a simple patch test methodology. Results: Ointment dermatological testing on rats, proved to be bearable on epilated skin at concentrations of 1, 2 and 5%. Ointments and mother tincture with higher concentrations (10% and 20%), led to irritation and cutis damages, and this was revealed through histology. Conclusion: Ointment tested on dog's skin was tolerable for epilated skin to concentrations of 1, 2 and/or 5%, additional testing on human volunteers confirmed the same situation.

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