Restless Legs Syndrome/Willis-Ekbom Disease Morbidity

Stevens, Mary Suzanne

doi:10.1016/j.jsmc.2015.05.017

Cited by 40 publications

(20 citation statements)

References 31 publications

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“…Disruption of sleep length and quality, daytime alertness can contribute to depression and anxiety. Increasing sympathetic tone due to PLMS may lead to cardiovascular disease and high blood pressure (Stevens, 2015). …”

Section: Clinical Presentations and Diagnostic Criteriamentioning

confidence: 99%

Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management

Guo

Huang

Jiang

et al. 2017

Front. Aging Neurosci.

125

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Restless legs syndrome (RLS), a common neurological sensorimotor disorder in western countries, has gained more and more attention in Asian countries. The prevalence of RLS is higher in older people and females. RLS is most commonly related to iron deficiency, pregnancy and uremia. The RLS symptoms show a significant circadian rhythm and a close relationship to periodic limb movements (PLMs) in clinical observations, while the pathophysiological pathways are still unknown. The diagnostic criteria have been revised in 2012 to improve the validity of RLS diagnosis. Recent studies have suggested an important role of iron decrease of brain in RLS pathophysiology. Dopaminergic (DA) system dysfunction in A11 cell groups has been recognized long ago from clinical treatment and autopsy. Nowadays, it is believed that iron dysfunction can affect DA system from different pathways and opioids have a protective effect on DA system. Several susceptible single nucleotide polymorphisms such as BTBD9 and MEIS1, which are thought to be involved in embryonic neuronal development, have been reported to be associated with RLS. Several pharmacological and non-pharmacological treatment are discussed in this review. First-line treatments of RLS include DA agents and α2δ agonists. Augmentation is very common in long-term treatment of RLS which makes prevention and management of augmentation very important for RLS patients. A combination of different types of medication is effective in preventing and treating augmentation. The knowledge on RLS is still limited, the pathophysiology and better management of RLS remain to be discovered.

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Section: Clinical Presentations and Diagnostic Criteriamentioning

confidence: 99%

Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management

Guo

Huang

Jiang

et al. 2017

Front. Aging Neurosci.

125

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“…Sleep disorders such as restless legs syndrome and insomnia are known to impact patients’ quality of life, 5,6 but recent studies have suggested that sleep duration may also be an important predictor of an individual’s health status. For example, sleep duration, particularly short sleep duration (<7 hours sleep in a 24-hour period), may be associated with sociodemographics, mental health, risk behaviors, and chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Relationship between sleep duration and self-reported health-related quality of life among US adults with or without major chronic diseases, 2014

et al. 2018

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Objectives To assess the association between sleep duration and health-related quality of life (HRQOL) among adults with or without chronic conditions. Methods Using the 2014 Behavioral Risk Factor Surveillance System, we analyzed self-reported data from adult respondents aged ≥18 years with (n = 277,757, unhealthy group) and without (n = 172,052. healthy group) reported history of any of nine chronic conditions (coronary heart disease, stroke, cancer, chronic obstructive pulmonary disease, diabetes, asthma, arthritis, depression, chronic kidney disease). Multivariable logistic regressions were separately constructed to assess the associations between sleep duration and four self-reported HRQOL measures after adjustment for sociodemographics, leisure-time physical activity, body mass index, and smoking status among unhealthy and healthy adults. Results The prevalence of poor/fair health, frequent physical distress, frequent mental distress, frequent activity limitation, and short sleep duration was 27.9%, 19.3%, 17.0%, 13.6%, and 38.3% in the unhealthy group and 6.9%, 4.0%, 5.3%, 2.1%, and 31.0% in the healthy group, respectively. U-shaped relationships of sleep duration to all four HRQOL indicators were observed among the unhealthy group and to poor/fair health, frequent mental distress, and frequent activity limitation among the healthy group. The relationships further varied by sex, age, race/ethnicity, and BMI category among the healthy group. Conclusions Relationships between extreme sleep duration and HRQOLs were observed among both healthy and unhealthy groups. These results can help inform public awareness campaigns and physician-counseling regarding the importance of sleep for mental health and well-being.

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“…Svar bu yra tai, kad ras ta vidu ti nio stip ru mo ne igia ma ko re lia ci ja tarp TNKS ska lës ba lø ir skaus mo ver ti ni mo, t. y., sun kë jant NKS simp to mø nað tai, di dë ja ir skaus mo su ke lia mas dis kom for tas. Apiben dri nant, NKS tu ri pa na ðià ne igia mà áta kà gy ve ni mo koky bei kaip ir kai ku rios ki tos lë ti nës li gos, pa vyz dþiui, cukri nis dia be tas [18].…”

Section: Rezultatø Aptarimasunclassified

Sergančiųjų pirminiu neramių kojų sindromu psichosocialiniai, fiziniai, kognityviniai ir gyvenimo kokybės ypatumai

Jarašiūnaitė¹,

Kaladytė-Lokominienė²

2019

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Įvadas. Neramių kojų sindromas (NKS) yra lėtinis neurologinis sutrikimas, pasireiškiantis nemaloniais pojūčiais kojose ar (ir) kitose kūno dalyse bei nenumaldomu noru judėti, kad sumažėtų jutiminis diskomfortas. Šis sindromas paveikia 5-15 % populiacijos visame pasaulyje. NKS turi didelės įtakos gyvenimo kokybei. Sindromui būdingas sutrikdytas nakties miegas ir mieguistumas dieną. Atlikta nemažai tyrimų dėl NKS sąsajų su pažintinių funkcijų blogėjimu, tačiau jų rezultatai yra skirtingi. Tiriamieji ir tyrimo metodai. 2019 m. sausio-kovo mėnesiais Vilniaus universiteto ligoninės Santaros klinikų Neurologijos centre atliktame tyrime dalyvavo 19 sergančiųjų pirminiu NKS ir 20 pagal amžių, išsilavinimą, lytį atrinktų NKS neturinčių kontrolinės grupės asmenų. Tyrimo dalyviams pateikta anketa su tarptautine NKS vertinimo skale TNKS, demografiniais duomenimis, gyvenimo kokybės vertinimo klausimynu SF-36, ligoninei pritaikyta depresijos ir nerimo skale HADS, pažinimo funkcijų vertinimo testu MoCA, Epworth mieguistumo dieną ir nuovargio klausimynais. NKS grupės tyrimo dalyvių judėjimo greitis įvertintas terminuoto atsistojimo ir 10 metrų ėjimo testu TUG. Statistinė analizė atlikta SPSS 23.0 programa, naudota Pearson koreliacija, chi² testas, dviejų imčių t-testas. Duomenys laikyti statistiškai reikšmingais, kai p < 0,05. Rezultatai. Tyrime dalyvavo 39 asmenys (32 moterys), kurių amžius – 65,1 ± 11,3 m. Statistiškai reikšmingai skyrėsi asmenų su NKS ir kontrolinės grupės tiriamųjų bendras MoCA rezultatas (p = 0,007), dėmesio (p = 0,002) ir ilgalaikio atgaminimo (p = 0,005) įverčiai. NKS grupės SF-36 klausimyno sveikatos būklės įvertis buvo mažesnis nei kontrolinės grupės asmenų (p = 0,032). Nustatyta vidutinio stiprumo neigiama koreliacija tarp TNKS skalės balų sumos ir skausmo (p < 0,001, r = -0,694) bei sveikatos būklės įverčių (p = 0,009, r = -0,585). TUG testo metu išmatuotas laikas su TNKS skalės balais nekoreliavo (p = 0,523, r = 0,156). Statistiškai reikšmingai nesiskyrė NKS ir kontrolinės grupių HADS depresijos ir nerimo rezultatai (p = 0,282 ir p = 0,219) bei mieguistumo ir nuovargio įverčiai (p = 0,141 ir p = 0,109, atitinkamai). Išvados. NKS pasireiškimo sunkumas turi ryšį su pacientų gyvenimo kokybės blogėjimu (pagal skausmo ir sveikatos būklės vertinimą). NKS nesusijęs su aukštesniais depresiškumo ir nerimastingumo įverčiais. Judėjimo greičio vertinimo rezultatai nėra susiję su NKS sunkumu. Sergančiųjų NKS pažinimo funkcijų įverčiai yra blogesni nei kontrolinėje grupėje.

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Restless Legs Syndrome/Willis-Ekbom Disease Morbidity

Cited by 40 publications

References 31 publications

Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management

Restless Legs Syndrome: From Pathophysiology to Clinical Diagnosis and Management

Relationship between sleep duration and self-reported health-related quality of life among US adults with or without major chronic diseases, 2014

Sergančiųjų pirminiu neramių kojų sindromu psichosocialiniai, fiziniai, kognityviniai ir gyvenimo kokybės ypatumai

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