Restless legs syndrome induced by citalopram: a psychiatric emergency?

Perroud, Nader; Lazignac, Coralie; Baleydier, Bertrand; Cicotti, Andrei; Maris, Stella; Damsa, Cristian

doi:10.1016/j.genhosppsych.2006.10.006

Cited by 32 publications

(8 citation statements)

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“…While some studies investigating the use of antidepressants and RLS reported no the association between both conditions [5,19,20], other stated a significant association between the two [10,14]. In several studies, the use of citalopram, escitalopram, fluoxetine, paroxetine, sertraline, bupropion, venlafaxine, duloxetine, and mirtazapine was reported to increase the risk of RLS [10,[21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Is there any association between antidepressants and restless legs syndrome in a large Turkish population receiving mono or combined treatment? A cross-sectional comparative study

Odabaş

Uca

2018

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: Here, we aimed at investigating whether the treatment with antidepressants is associated with restless legs syndrome (RLS) and at determining the effects of mono or combined antidepressant therapy on the patients with RLS. METHODS: Five hundred and fifty-five patients with RLS receiving mono or combined antidepressant therapy were included in the study group, and 555 individuals with no history of the use of antidepressants constituted the control group. The diagnosis of restless leg syndrome was performed using a questionnaire under the criteria formed by the International Restless Leg Syndrome Study Group. RESULTS: Both the patients treated with antidepressants in the study group and those in the control group had similar demographic characteristics. The prevalence of RLS was detected as 9.2% (n = 51) in the study group treated with antidepressants and as 5.9% (n = 33) in the controls. The difference was statistically significant at borderline (p = 0.053). While restless leg syndrome was diagnosed merely in 9 (6.8%) of 133 patients receiving combined treatment, 42 (10%) of 422 patients receiving monotherapy were diagnosed with RLS, and the difference was not statistically significant (p = 0.306). The frequency of developing restless leg syndrome was found to be significant only in the use of escitalopram (p = 0.023), whereas it was found to have a tendency to significant in the use of duloxetine (p = 0.060). Among other participants receiving mono or combined treatment, no significant difference was observed. CONCLUSIONS: The occurrence of RLS can be seen as an adverse effect in the patients receiving mono or combined antidepressant treatment; however, the frequency of restless leg syndrome among those treated with antidepressants is similar to that seen in general population. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Is there any association between antidepressants and restless legs syndrome in a large Turkish population receiving mono or combined treatment? A cross-sectional comparative study

Odabaş

Uca

2018

Psychiatry and Clinical Psychopharmacology

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“…Antidepressant-induced RLS was reported more frequently with selective serotonin reuptake inhibitors (SSRIs) including sertraline, citalopram, paroxetine, fluoxetine, escitalopram, and the tetracyclic antidepressant mirtazapine ( Table 2). [32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] The mechanism of antidepressant-induced RLS is unclear. It has been hypothesized that enhancing serotonin and norepinephrine combined with dopaminergic inhibition may lead to RLS.…”

Section: Antidepressant Case Reportsmentioning

confidence: 99%

Drug-Induced Restless Legs Syndrome

Patatanian

Claborn

2018

Ann Pharmacother

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“…[318] Mirtazepine has been found to induce RLS more frequently compared to other antidepressants including SSRI. [1819] In the present study, most of the patients had longstanding illness spanning upto 10 years and were taking antidepressants off and on. Since, RLS was never screened they were not able to recall its relationship with antidepressant therapy.…”

Section: Discussionmentioning

confidence: 91%

Prevalence of restless leg syndrome in subjects with depressive disorder

Gupta

Lahan

Goel

2013

Indian J Psychiatry

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Background:Restless legs syndrome (RLS) is known to be associated with depression. We hypothesized that RLS in depression is linked to the severity, duration, and frequency of depressive episodes.Materials and Methods:Subjects fulfilling DSM-IV-TR criteria of depressive disorders were included in this study after seeking informed consent. Using structured interview of MINI-Plus their demographic data and history were recorded. Severity of depression was assessed with the help of HAM-D. Insomnia was diagnosed following ICSD-2 criteria. RLS was diagnosed according to IRLSSG criteria. Descriptive statistics, Chi-square test, independent sample t test and MANOVA were computed with the help of SPSS v 17.0.Results:RLS was reported by 31.48% of sample. There was no gender difference in prevalence of RLS (X2 =0.46; P=0.33). There was no difference in the age , total duration of depressive illness and number of depressive episodes between RLS and non-RLS groups (F=0.44; P=0.77; Wilk's Lambda=0.96). The HAM-D score was higher in the non-RLS group (P=0.03). Onset of RLS symptoms was not related to onset of depressive symptoms.Conclusion:RLS is prevalent in depressive disorder. However, onset of RLS is unrelated to age and number or duration of depressive disorders.

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Restless legs syndrome induced by citalopram: a psychiatric emergency?

Cited by 32 publications

References 10 publications

Is there any association between antidepressants and restless legs syndrome in a large Turkish population receiving mono or combined treatment? A cross-sectional comparative study

Is there any association between antidepressants and restless legs syndrome in a large Turkish population receiving mono or combined treatment? A cross-sectional comparative study

Drug-Induced Restless Legs Syndrome

Prevalence of restless leg syndrome in subjects with depressive disorder

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