Prevalence of restless leg syndrome in subjects with depressive disorder

Abstract

Background:Restless legs syndrome (RLS) is known to be associated with depression. We hypothesized that RLS in depression is linked to the severity, duration, and frequency of depressive episodes.Materials and Methods:Subjects fulfilling DSM-IV-TR criteria of depressive disorders were included in this study after seeking informed consent. Using structured interview of MINI-Plus their demographic data and history were recorded. Severity of depression was assessed with the help of HAM-D. Insomnia was diagnosed following ICSD-2 criteria. RLS was diagnosed according to IRLSSG criteria. Descriptive statistics, Chi-square test, independent sample t test and MANOVA were computed with the help of SPSS v 17.0.Results:RLS was reported by 31.48% of sample. There was no gender difference in prevalence of RLS (X2 =0.46; P=0.33). There was no difference in the age , total duration of depressive illness and number of depressive episodes between RLS and non-RLS groups (F=0.44; P=0.77; Wilk's Lambda=0.96). The HAM-D score was higher in the non-RLS group (P=0.03). Onset of RLS symptoms was not related to onset of depressive symptoms.Conclusion:RLS is prevalent in depressive disorder. However, onset of RLS is unrelated to age and number or duration of depressive disorders.

Elevation of tumor necrosis factor alpha levels is associated with restless legs symptoms in clinically depressed patients

“…The prevalence of restless legs symptoms was 24.8% in the controls. Respectively, previous population studies have reported the prevalence of restless legs syndrome that estimates as high as 24% [43][44][45], and among patients with depression the prevalence that estimates as high as 31.5% [46]. The association between TNF-α and depression is not significant constantly; for instance, obesity may confuse the correspondence [47].…”

Suspected Agomelatine-induced restless legs syndrome: a case report

“…It is notable that our patient suffered from depression and RLS. Gupta et al’s cross-sectional assessment found a 31.5% prevalence of RLS among patients diagnosed with MDD [ 34 ]. A high rate of depression has also been reported in patients with RLS, although prevalence rates seem to be related to RLS severity [ 35 , 36 ].…”

Is There an Association between Restless Legs Syndrome and Urticaria?

“…The exact pathogenesis of RLS is unknown ( 1 ). RLS patients especially have difficulty falling asleep or maintaining sleep ( 1 2 ). Criteria for the diagnosis of RLS were first introduced by the International Restless Leg Syndrome Study Group (IRLSSG) in 2003 ( 2 ).…”

“…RLS patients especially have difficulty falling asleep or maintaining sleep ( 1 2 ). Criteria for the diagnosis of RLS were first introduced by the International Restless Leg Syndrome Study Group (IRLSSG) in 2003 ( 2 ). According to these, the urge to move the legs, worsening of symptoms with rest or inactivity, improvement with movement and impairment during evening or night hours compared to daytime are the diagnostic indicators of RLS ( 2 ).…”

“…Criteria for the diagnosis of RLS were first introduced by the International Restless Leg Syndrome Study Group (IRLSSG) in 2003 ( 2 ). According to these, the urge to move the legs, worsening of symptoms with rest or inactivity, improvement with movement and impairment during evening or night hours compared to daytime are the diagnostic indicators of RLS ( 2 ). RLS is idiopathic in nature in most cases, but can be secondary to conditions such as diabetes mellitus (DM), renal failure, and iron deficiency anemia.…”