Restless legs syndrome during pregnancy in Brazilian women

Alves, Débora Almeida Galdino; Carvalho, Luciane Bizari Coin de; Morais, José Fausto de; Prado, Gilmar Fernandes do

doi:10.1016/j.sleep.2010.06.006

Cited by 66 publications

(49 citation statements)

References 47 publications

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“…The prevalence of RLS during pregnancy found in this study corresponds well with previous studies (1,(6)(7)(8)(9)(10)(11)(12). Previous studies describe an increased appearance and worsening of RLS-symptoms in the last trimester of pregnancy (1,(10)(11)(12)17), whereas our data indicated an earlier onset of symptoms and an unchanged occurrence between the 2 nd and 3 rd trimester of pregnancy.…”

Section: Discussionsupporting

confidence: 91%

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Restless legs syndrome during and after pregnancy and its relation to snoring

Sarberg¹,

Josefsson²,

Wiréhn³

et al. 2012

Acta Obstet Gynecol Scand

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Restless legs syndrome during and after pregnancy and its relation to snoring, 2012, Acta Obstetricia et Gynecologica Scandinavica, (91), 7, 850-855. which has been published in final form at: http://dx.doi.org/10.1111/j. 1600-0412.2012 Design. Prospective study.Setting. Antenatal care clinics in the catchment area of Linköping university hospital, Sweden.Population. Five hundred consecutively recruited pregnant women. Methods. Sleep disturbances, including symptoms of restless legs syndromeand snoring was assessed with questionnaires in each trimester. A complementary questionnaire was sent three years after delivery to women experiencing RLS-symptoms during pregnancy. Main outcome measures. RLS-symptoms in relation to snoring in each trimester.Results. RLS-symptoms were reported by 17.0 % of the women in the 1 st , by 27.1 % in the 2 nd and by 29.6 % in the 3 rd trimester. Snoring in the 1 st trimester was correlated to increased prevalence of RLS in all three trimesters (p=0.003, 0.017 and 0.044). No correlation was found between RLS and anemia, parity or body mass index. Among the RLS women 31% still had symptoms three years after delivery. Fifty-eight percent of those whose symptoms had disappeared stated that this happened within one month after delivery. Conclusions

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Section: Discussionsupporting

confidence: 91%

“…Most of these studies are retrospective or cross-sectional (7,(9)(10)(11)(12). To our knowledge there is no large prospective study focusing on the development of RLS during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Restless legs syndrome during and after pregnancy and its relation to snoring

Sarberg¹,

Josefsson²,

Wiréhn³

et al. 2012

Acta Obstet Gynecol Scand

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“…In European and North American countries, a prevalence of 11-27%, in Brazil 13.5% or Pakistan 30% of RLS in pregnancy has been described. [9][10][11] In pregnancy, the majority experience RLS for the first time or experience a worsening of symptoms. 9 …”

Section: Introductionmentioning

confidence: 99%

Is preeclampsia associated with restless legs syndrome?

Ramirez

Cabrera

Hidalgo³

et al. 2013

Sleep Medicine

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OBJECTIVE: Restless legs syndrome (RLS) is a common neurologic disorder. Secondary RLS includes pregnancy and iron deficiency. Prevalence of RLS in pregnancy ranges from 11% to 27%. We aimed to assess the frequency and characteristics of RLS in pregnancy in a Peruvian population and to evaluate the possible pregnancy or delivery complications due to RLS. METHODS: We assessed 218 consecutive expectant mothers at the inpatient clinic of the Hospital San Bartolome in Lima, Peru. Assessment was performed by using the standard diagnostic criteria for RLS and by using a clinical and diagnostic interview. Questionnaires for RLS severity, idiopathic RLS (IRLS), and excessive daytime sleepiness (EDS) according to the Epworth sleepiness scale (ESS) were used. Blood examination was performed for hemoglobin and hematocrit. For comparison, RLS patients were matched for age and body mass index (BMI) with pregnant women without RLS. RESULTS: Out of 218 patients, 40 (18.4%) fulfilled diagnostic criteria for RLS. In RLS patients, prophylactic iron supplementation therapy during pregnancy was less frequently taken (P=.02). Pregnant women with RLS had a higher ESS score than pregnant controls (10.6 +/-3.1 vs 7.6. +/-3.6; P<.001). Preeclampsia was more frequent in RLS (7/40 vs 1/39; P=.03). CONCLUSIONS: In our study, RLS was frequent in pregnant Peruvian women, especially in those without prophylactic iron supplementation. RLS patients described more EDS. Preeclampsia was more common in RLS. Our study is the first study to indicate a possible association between RLS and preeclampsia. Restless legs syndrome (RLS) is a common neurological disorder. Secondary RLS includes pregnancy and iron deficiency. Prevalence of RLS in pregnancy ranges between 11-27%. We aimed at assessing frequency and characteristics of RLS in pregnancy in a Peruvian population and to evaluate possible pregnancy or delivery complications due to RLS. Methods:We assessed 218 consecutive expectant mothers at the inpatient clinic of the Hospital San Bartolome, Lima, Peru. Assessment was performed by using the standard diagnostic criteria for RLS and by a clinical-diagnostic interview. Questionnaires for RLS severity (IRLS) and excessive daytime sleepiness (EDS) by Epworth Sleepiness Scale (ESS) were used. Blood examination was performed for hemoglobin and hematocrit. For comparison, RLS patients were matched for age-and BMI with pregnant women without RLS. Results:Out of 218 patients, 40 (18.4%) fulfilled diagnostic criteria for RLS. In RLS patients, prophylactic iron supplementation therapy during pregnancy was taken less frequently (p=0.02). Pregnant women with RLS had a higher ESS score than pregnant controls (10.6 +/-3.1 vs. 7.6. +/-3.6; p<0.001). Preeclampsia was more frequent in RLS (7/40 vs. 1/39; p=0.03). Conclusions:In our study, RLS was frequent in pregnant Peruvian women, especially in those without prophylactic iron supplementation. RLS patients described more daytime sleepiness.Preeclampsia was more common in RLS. This is the first study indic...

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“…Restless Legs Syndrome (IRLS) Study Group rating scale, severe symptoms have been reported in 45% and 54% of pregnant women in two recent studies 8,9 . Genetic, metabolic, and hormonal factors, such as iron deficiency and elevated estradiol levels, have all been proposed as determinants of pregnancy-related RLS.…”

Section: Introductionmentioning

confidence: 99%

Open-label study of the efficacy and safety of intravenous ferric carboxymaltose in pregnant women with restless legs syndrome

et al. 2015

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Open-label study of the efficacy and safety of intravenous ferric carboxymaltose in pregnant women with restless legs syndrome, Sleep Medicine (2015), http://dx.doi.org/doi: 10.1016/j.sleep.2015.08.006. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Neurocenter of Southern Switzerland (Lugano). Patient and Methods:Nineteen women in the third trimester of pregnancy with moderateto-severe RLS and serum ferritin levels <35 µg/L or hemoglobin (Hb) <11.0 g/dl were included in the study. RLS was graded according to the International Restless Legs Syndrome (IRLS) Study Group rating scale. All participants had a score of ≥20 or had RLS ≥3 times/week. Depending on Hb levels, 500 or 700 mg of FCM was administered over 20 min. The primary endpoint was a ≥50% reduction in the mean IRLS score 1 week after FCM infusion. Secondary endpoints included periodic limb movements (PLMs; assessed using nocturnal foot actigraphy), sleep quality (assessed using the Pittsburgh Sleep Quality Index), and safety. Results:The IRLS score decreased from 23 ± 7 (baseline) to 13 ± 7 (P < 0.01), whereas the PLM index decreased from 35 ± 26 (baseline) to 25 ± 20 (P < 0.001). Significant improvement in sleep quality was also reported (P < 0.029), and treatment was well tolerated. Three serious adverse events were reported but were considered unrelated to treatment. Conclusions:These data provides promising evidence of the safety and efficacy of FCM for moderate-to-severe RLS in pregnant women with iron deficiency or anemia. A future placebo-controlled study is therefore warranted.

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Restless legs syndrome during pregnancy in Brazilian women

Cited by 66 publications

References 47 publications

Restless legs syndrome during and after pregnancy and its relation to snoring

Restless legs syndrome during and after pregnancy and its relation to snoring

Is preeclampsia associated with restless legs syndrome?

Open-label study of the efficacy and safety of intravenous ferric carboxymaltose in pregnant women with restless legs syndrome

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