Restless legs syndrome during and after pregnancy and its relation to snoring

Sarberg, Maria; Josefsson, Ann; Wiréhn, Ann-Britt; Svanborg, Eva

doi:10.1111/j.1600-0412.2012.01404.x

Cited by 46 publications

(41 citation statements)

References 30 publications

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“…There is a clear and profound drop in RLS/WED symptoms around delivery, with complete resolution of symptoms for approximately 70% of affected women and a significant decrease in severity for the remainder [2,13,14,59]. For women with new onset of RLS/WED during pregnancy, the resolution rate appears to exceed 90% [41,55].…”

Section: Prevalence and Clinical Course Of Rls/wed During Pregnancymentioning

confidence: 98%

“…The prevalence and severity of RLS/WED has been found to progressively increase over the course of pregnancy in most studies, with a peak around the 7 to 8 th month and stability or a slight decrease in the last month of pregnancy [3,14,[56][57][58][59]. There is a clear and profound drop in RLS/WED symptoms around delivery, with complete resolution of symptoms for approximately 70% of affected women and a significant decrease in severity for the remainder [2,13,14,59].…”

Section: Prevalence and Clinical Course Of Rls/wed During Pregnancymentioning

confidence: 99%

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Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

Picchietti¹,

Hensley²,

Bainbridge³

et al. 2015

Sleep Medicine Reviews

131

106

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Section: Prevalence and Clinical Course Of Rls/wed During Pregnancymentioning

confidence: 98%

Section: Prevalence and Clinical Course Of Rls/wed During Pregnancymentioning

confidence: 99%

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

Picchietti¹,

Hensley²,

Bainbridge³

et al. 2015

Sleep Medicine Reviews

131

106

View full text Add to dashboard Cite

“…33 In another Swedish population, RLS was linked to daytime fatigue and excessive daytime sleepiness in the third trimester. 28 Among a Chinese cohort, RLS was associated with a high frequency of poor sleep (82%) and excessive daytime sleepiness (40%). 32 Other Asian studies have found an association between RLS and excessive daytime sleepiness, 30,31,34 one of which reported a dose-response relationship with RLS frequency (1-6 times/wk and ≥ 7 times/wk).…”

Section: Discussionmentioning

confidence: 99%

Restless Legs Syndrome and Sleep-Wake Disturbances in Pregnancy

Dunietz

Lisabeth²,

Shedden³

et al. 2017

Journal of Clinical Sleep Medicine

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Study Objectives: To estimate the association of restless legs syndrome (RLS) and its frequency with sleep-wake disturbances in pregnancy. Methods: A cohort of 1,563 women in their third trimester of pregnancy were recruited from prenatal clinics between March 2007 and December 2010. Demographic, pregnancy, and delivery data were extracted from medical records and sleep information was collected with questionnaires. To diagnose RLS, we used standardized criteria of RLS symptoms and frequency that were developed by the International Restless Legs Study Group. Logistic regression models were constructed to investigate the association of RLS and its frequency with sleep-wake disturbances (poor sleep quality, daytime sleepiness, poor daytime function) and delivery outcomes. Results: Overall 36% of the pregnant women had RLS, and half had moderate to severe symptoms. Compared to women without RLS, those with RLS were more likely to have poor sleep quality (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.7-2.9), poor daytime function (OR 1.9, 95% CI 1.4-2.4), and excessive daytime sleepiness (OR 1.6, 95% CI 1.3-2.0). A dose-response relationship also was evident between RLS frequency and each of the sleep-wake disturbances. There was no evidence for any association between RLS and delivery outcomes. Conclusions: RLS is a significant contributor to poor sleep quality, daytime sleepiness, and poor daytime function, all common and often debilitating conditions in pregnancy. Obstetric health care providers should be aware of these associations and screen women for RLS. I NTRO DUCTI O NRestless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensorimotor disorder composed of an urge to move, with or without associated discomfort that occurs with inactivity and improves with movement. It follows a circadian pattern, with a predilection for the evening and night.1 RLS is a common, underdiagnosed condition that affects up to 5% of the population worldwide, 2-4 with up to 15% prevalence in Caucasians. 5 The prevalence of RLS is positively correlated with age and body mass index (BMI) among both men and women.6,7 Although RLS has a genetic predisposition, it is also associated with other conditions such as end-stage renal disease, neuropathy, and pregnancy. 8 RLS affects up to one-third of pregnant women 9,10 peaks in the third trimester, 9-11 and usually subsides after delivery. 11Multiparous women are affected up to three times more often than nulliparous women. 10 The high prevalence of RLS during pregnancy has been attributed to hemodynamic and hormonal changes, iron and folate metabolism, and psychomotor behaviors.12 Although RLS is related to reduced quality of life and poor sleep in the general population 13,14 data on RLSassociated maternal sleep-wake disturbances are lacking. pregnancy and delivery outcomes (eg, preterm delivery, prolonged labor, cesarean section deliveries, and postpartum depression). [15][16][17] Therefore, the goal of this study was twofold: (1) to examine the frequency of RLS in ...

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“…A Swedish study showed that snoring in the first trimester was correlated with increased prevalence of RLS in all 3 trimesters. 18 Sleep apnea, which is highly prevalent in late pregnancy, is also known to exacerbate and trigger RLS. 19 Fetal growth and consequent stretch/ compression of the nerve roots have been suggested as a potential contributing factor for RLS during pregnancy.…”

Section: Pregnancy-related Risk Factors For Restless Legs Syndromementioning

confidence: 99%