Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation

Didato, Giuseppe; Giacomo, Roberta Di; Rosa, Giuseppa Jolanda; Dominese, Ambra; Curtis, Marco de; Lanteri, Paola

doi:10.3390/ijerph17103658

Cited by 52 publications

(45 citation statements)

References 79 publications

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“…[ 3 ] Associated comorbidities can complicate or modify the different aspects of RLS, and treatment may include both RLS and associated comorbid conditions. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

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Dopa responsive headache: Restless head syndrome or a cephalic variant of restless legs syndrome?

Prakash

2020

J Family Med Prim Care

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Restless legs syndrome (RLS) is a common but highly undiagnosed sensorimotor disorder. It typically affects the lower extremities. However, various other parts of the body can be involved, such as the arms, the abdomen, the face, the oral cavity, head-neck, and the genital area. In addition, RLS is linked with a large number of comorbid conditions, including various headache disorders. Herein we are reporting two cases of RLS who also had headaches. The headaches fulfilled the criteria of chronic tension-type headache (CTTH). The administration of levodopa provided improvement in both RLS and CTTH. We suggest that that headache in a subset of patients with RLS may be the part of RLS symptoms complex.

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“…[ 3 ] Associated comorbidities can complicate or modify the different aspects of RLS, and treatment may include both RLS and associated comorbid conditions. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 ] Restlessness genital syndrome, Restless mouth syndrome, restless abdomen syndrome, restless bladder syndrome are other few variants in this regard. [ 8 10 11 12 ] Insomnia is one of the important accompanying symptoms in patients with RLS. Isolated insomnia has also been described as a variant of RLS.…”

Section: Discussionmentioning

confidence: 99%

Dopa responsive headache: Restless head syndrome or a cephalic variant of restless legs syndrome?

Prakash

2020

J Family Med Prim Care

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“…As a sleep-related sensorimotor disorder, RLS can be divided into primary RLS and secondary RLS ( 19 ). RLS caused by ESRD is one of the most common secondary RLS ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

Relation of Serum Hepcidin Levels and Restless Legs Syndrome in Patients Undergoing Peritoneal Dialysis

et al. 2021

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Introduction: Restless legs syndrome is a common and severe complication in patients undergoing peritoneal dialysis (PD), which seriously affects the life quality and prognosis of patients undergoing PD. Unfortunately, there are still no effective prevention and treatment measures. Serum hepcidin was demonstrated to be related to primary restless legs syndrome (RLS), whereas there are no studies on the relationship between serum hepcidin and RLS in patients undergoing PD. We aimed to evaluate the role and function of serum hepcidin in patients undergoing PD with RLS.Methods: A total of 51 patients undergoing PD with RLS and 102 age-and gender-matched patients undergoing PD without RLS were included. We collected the clinical data including serum hepcidin of those patients undergoing PD. We scored the severity of RLS according to the International restless leg Syndrome Research Group rating scale (IRLS). We compared the clinical characteristics of the two groups and evaluated the determinant factors of RLS by Logistic regression analysis. In addition, we evaluated the diagnostic value of serum hepcidin in patients undergoing PD with RLS by receiver operating characteristic (ROC) curve. We also analyzed the influencing factors of IRLS by multivariate linear regression analysis.Results: The duration of PD, serum hepcidin, and calcium were found to be significantly higher in patients undergoing PD with RLS than those patients undergoing PD without RLS (P < 0.001, P < 0.001, and P = 0.002, respectively). The level of hemoglobin, albumin, and RKF were significantly lower in patients undergoing PD with RLS (P = 0.002, P = 0.042, and P < 0.001, respectively). The duration of PD [odds ratio (OR) 1.038, 95% CI: 1.017, 1.060, P < 0.001], hemoglobulin level (OR 0.969, 95% CI: 0.944, 0.995, P = 0.019), calcium level (OR 9.224, 95% CI: 1.261, 67.450, P = 0.029), albumin level (OR 0.835, 95% CI: 0.757, 0.921, P < 0.001), hepcidin level (OR 1.023, 95% CI: 1.009, 1.038, P = 0.001), and RKF (OR 0.65, 95% CI: 0.495, 0.856, P = 0.002) are independent determinant factors of RLS in patients undergoing PD. Multivariate linear regression analysis revealed that, in addition to albumin, they were also independently associated with the severity of RLS.Conclusion: A significant relation was detected between serum hepcidin level and RLS in patients undergoing PD.

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“…RLS used to be classified into idiopathic, primary, inherited, and secondary to a variety of chronic diseases [29,30]. On the other hand, "RLS mimics" refers to conditions that need to be considered in the differential diagnosis, such as arthritis, leg cramps, peripheral neuropathy, and leg edema.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Restless Legs Syndrome and its Symptoms among Patients with Spinal Disorders

Terai

Toyoda

Hoshino

et al. 2021

JCM

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Restless legs syndrome (RLS) is a neurological disorder that causes uncomfortable sensations in the legs. The purpose of this study was to evaluate the symptoms of RLS in patients with spinal disorders and the impact of RLS on the clinical outcomes of lumbar spinal stenosis (LSS). The records of 278 patients (age range 65–92 years) with spinal disorders who visited our outpatient clinic were reviewed. We used a survey to identify subjects with RLS based on the International RLS Study Group diagnostic criteria. We further recorded patient characteristics, surgical outcomes, sleeping time, mental health condition, and the occurrence of leg cramps. Thirty-two patients (11.5%) met the criteria for RLS. The prevalence of anxiety (46.9% vs. 26.6%, p = 0.023) and leg cramps (90.6% vs. 73.2%, p = 0.030) was higher in patients with RLS than in those without. RLS was present in 12.3% of LSS patients. The visual analog scale score for lower back pain before surgery and at the final follow-up was significantly higher in LSS patients with RLS than in those without. However, the Japanese Orthopaedic Association (JOA) score, JOA score improvement ratio, and VAS score for leg numbness were not significantly different between the groups.

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Restless Legs Syndrome across the Lifespan: Symptoms, Pathophysiology, Management and Daily Life Impact of the Different Patterns of Disease Presentation

Cited by 52 publications

References 79 publications

Dopa responsive headache: Restless head syndrome or a cephalic variant of restless legs syndrome?

Dopa responsive headache: Restless head syndrome or a cephalic variant of restless legs syndrome?

Relation of Serum Hepcidin Levels and Restless Legs Syndrome in Patients Undergoing Peritoneal Dialysis

Prevalence of Restless Legs Syndrome and its Symptoms among Patients with Spinal Disorders

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