Resting-State Functional Connectivity Measurement in the Mouse Brain using a Low Cost Photoacoustic Computed Tomography

Hariri, Ali; Omidi, Parsa; Avanaki, Kamran

doi:10.1364/fio.2016.jw4a.62

Cited by 18 publications

(11 citation statements)

References 22 publications

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“…It has also shown great potential for clinical translatability. Such translation, especially for neonatal brain and breast imaging, requires an imaging system with a large detection view, fast acquisition and volumetric imaging capability [7,[20][21][22][23][24][25]. Towards clinical translation, we have tested the feasibility of a stationary 3D HA-PACT imaging system with a full-field illumination scheme.…”

Section: Discussionmentioning

confidence: 99%

Development of a Stationary 3D Photoacoustic Imaging System Using Sparse Single-Element Transducers: Phantom Study

et al. 2019

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Photoacoustic imaging (PAI) is an emerging label-free and non-invasive modality for imaging biological tissues. PAI has been implemented in different configurations, one of which is photoacoustic computed tomography (PACT) with a potential wide range of applications, including brain and breast imaging. Hemispherical Array PACT (HA-PACT) is a variation of PACT that has solved the limited detection-view problem. Here, we designed an HA-PACT system consisting of 50 single element transducers. For implementation, we initially performed a simulation study, with parameters close to those in practice, to determine the relationship between the number of transducers and the quality of the reconstructed image. We then used the greatest number of transducers possible on the hemisphere and imaged copper wire phantoms coated with a light absorbing material to evaluate the performance of the system. Several practical issues such as light illumination, arrangement of the transducers, and an image reconstruction algorithm have been comprehensively studied.

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Section: Discussionmentioning

confidence: 99%

Development of a Stationary 3D Photoacoustic Imaging System Using Sparse Single-Element Transducers: Phantom Study

et al. 2019

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“…Brenner gradient was first proposed by Brenner et al [46], as a fast edge detector, which measures the difference between a pixel value and that of its neighbors two points distant [9]. For a two-dimensional image, it can be formulated as…”

Section: Brenner Gradientmentioning

confidence: 99%

“…The absorption distribution across the tissue is then used to reconstruct either a two-dimensional (2D) or three-dimensional (3D) imaging, depending on configuration of PAI system [2][3][4][5][6]. Many configurations of PAI have been implemented for fine or coarse resolution imaging [3,5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Photoacoustic computed tomography (PACT), one of several PAI frameworks, provides features that aid in clinical applicability.…”

Section: Introductionmentioning

confidence: 99%

Transducer misplacement compensation for in-lab-made 3D photoacoustic tomography systems using nature-inspired algorithms

Rahaman¹,

Prakash

Ranjbaran

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Three-dimensional (3D) photoacoustic tomography is a method of choice for imaging round organs such as brain and breast. Many research groups have used a fully populated hemispherical transducer array with 256, 512, 1028, or 2048 elements and used that for 3D imaging. These transducer arrays are expensive and require a sophisticated data acquisition unit. Other groups have used much smaller number of transducers with a rotating mechanism which eventually filled out the entire hemisphere. We have built a 3D hemispherical array with 28 transducers which are placed on a 3D printed dome-like unit. The location of transducers however may be off-placed by a few millimeters (due to human error and errors in 3D printing). This may be to defocus the reconstructed image if the acceptable positions of transducers are not selected. In this work, we developed a compensation algorithm for misplacement of these transducers using Cuckoo search (CS) algorithm. The CS algorithm finds the optimum location for the transducers using levy flight which relies on levy distribution. The optimum location of each of these transducers is found within -4 mm to 4 mm of their locations. Universal back projection algorithm was used for image reconstruction and the sharpness of 3D image was used as the cost function; additionally, two more objective functions, the Brenner gradient, and the Tenenbaum gradient was investigated.

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“…This hybrid modality combines the advantages of high-resolution ultrasound imaging and, high contrast and deep penetration of microwave imaging. Two imaging techniques, photoacoustic imaging [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] and microwave-induced thermoacoustic imaging [6,25], are based on the thermoelastic effect [26]. While photoacoustic imaging uses light as the excitation source, microwave-induced thermoacoustic imaging uses microwave radiation, allowing for deeper imaging penetration.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of thermoacoustic imaging system using rotational single element transducer

Islam¹,

Zafar²,

Prakash³

et al. 2023

Photons Plus Ultrasound: Imaging and Sensing 2023

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Microwave-induced thermoacoustic tomography has the advantage of a high spatial resolution and a deep imaging depth. This method has been extensively explored over the past decade to find an alternative of existing imaging techniques. In this study, we have developed a compact microwave-induced thermoacoustic tomography (MI-TAT) with a waveguide antenna and a rotating ultrasound transducer unit. We performed a characterization study of the system in terms of pulse width, selection of microwave frequency and resolution. Then the optimized parameters were used to image in-vitro complex structure phantoms. Later, we expanded our system capability for spectroscopic study by imaging different concentrations of methanol and water to mimic the tissue properties and analyze them based on the absorption characteristics of these materials. We hope, this spectroscopic capability broadens the capability of thermoacoustic system to separate the diseased tissue from the healthy one (e.g., malignant from benign) with a high sensitivity and specificity.

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Resting-State Functional Connectivity Measurement in the Mouse Brain using a Low Cost Photoacoustic Computed Tomography

Cited by 18 publications

References 22 publications

Development of a Stationary 3D Photoacoustic Imaging System Using Sparse Single-Element Transducers: Phantom Study

Development of a Stationary 3D Photoacoustic Imaging System Using Sparse Single-Element Transducers: Phantom Study

Transducer misplacement compensation for in-lab-made 3D photoacoustic tomography systems using nature-inspired algorithms

Development and characterization of thermoacoustic imaging system using rotational single element transducer

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