Resting-state EEG gamma power and theta–gamma coupling enhancement following high-frequency left dorsolateral prefrontal rTMS in patients with depression

Noda, Yoshihiro; Zomorrodi, Reza; Saeki, Takashi; Rajji, Tarek K.; Blumberger, Daniel M.; Daskalakis, Zafiris J.; Nakamura, Motoaki

doi:10.1016/j.clinph.2016.12.023

Cited by 112 publications

(64 citation statements)

References 78 publications

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“…To counteract this limitation, we examined resting-state PSD, as well as ERP and ERS/ERD during the 3-back task, using exploratory cluster-based non-parametric permutation tests to account for the possibility that an effect may lie beyond our a priori hypotheses, and found no significant clusters. Nevertheless, more sophisticated analyses, such as theta-gamma phase-amplitude coupling (Sun et al, 2015;Noda et al, 2017), or dynamic causal modelling to determine changes in effective connectivity between brain regions (Lu et al, 2012;Harding et al, 2015;Breakspear, 2017), may reveal the effects of the intervention. For example, theta connectivity localised to the anterior cingulate cortex has been identified as a predictor of antidepressant response to treatment courses using transcranial magnetic stimulation (Narushima et al, 2010;Bailey et al, 2018), and sertraline (Pizzagalli et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Assessing neurophysiological changes associated with combined transcranial direct current stimulation and cognitive emotional training for treatment-resistant depression

Nikolin

Martin

Loo

et al. 2019

Preprint

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Transcranial direct current stimulation (tDCS), a form of non-invasive brain stimulation, is a promising treatment for depression. Recent research suggests that tDCS efficacy can be augmented using concurrent cognitive emotional training (CET). However, the neurophysiological changes associated with this combined intervention remain to be elucidated. We therefore examined the effects of tDCS combined with CET using electroencephalography (EEG). A total of 20 participants with treatment resistant depression took part in this open-label study and received 18 sessions over 6 weeks of tDCS and concurrent CET. Resting-state and task-related EEG during a 3-back working memory task were aquired at baseline and immediately following the treatment course. Results showed an improvement in mood and working memory accuracy, but not response time, following the intervention. We did not find significant effects of the intervention on resting-state power spectral density (frontal theta and alpha asymmetry), time-frequency power (alpha eventrelated desynchronization and theta event-related synchronisation), or event-related potentials (P2 and P3 components). We therefore identified little evidence of neurophysiological changes associated with treatment using tDCS and concurrent CET, despite significant improvements in mood and near transfer effects of cognitive training to working memory accuracy. Further research incorporating a sham controlled group may be necessary to identify the neurophysiological effects of the intervention.

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Section: Discussionmentioning

confidence: 99%

Assessing neurophysiological changes associated with combined transcranial direct current stimulation and cognitive emotional training for treatment-resistant depression

Nikolin

Martin

Loo

et al. 2019

Preprint

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“…In another study on the effects of HFL on resting‐state EEG in 31 patients diagnosed with depression, the authors reported significant increases of resting gamma power at the F3 and F4 electrode sites and resting theta‐gamma coupling at the C3 and T3 electrode sites. In addition, the increased gamma power at the F3 electrode site was significantly correlated with the improvements in depression . A study on the changes in functional connectivity before and after rTMS using resting‐state EEG ( N = 14 subjects with TRD) recorded at baseline and week 4, reported that HFL modulates the resting EEG functional connectivity between the left DLPFC and limbic regions, including the subgenual cingulate cortex and the parahippocampal gyrus …”

Section: Interindividual Variability and Personalized Treatment Selecmentioning

confidence: 99%

“…In addition, the increased gamma power at the F3 electrode site was significantly correlated with the improvements in depression. 88 A study on the changes in functional connectivity before and after rTMS using resting-state EEG (N = 14 subjects with TRD) recorded at baseline and week 4, reported that HFL modulates the resting EEG functional connectivity between the left DLPFC and limbic regions, including the subgenual cingulate cortex and the parahippocampal gyrus. 89 TMS can also be combined with EEG to derive rich temporal and spatial information.…”

Section: Interindividual Variability and Personalized Treatment Selecmentioning

confidence: 99%

An Update on Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder

Trevizol

Blumberger

2019

Clin Pharma and Therapeutics

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Repetitive transcranial magnetic stimulation (rTMS) has emerged as an evidenced‐based treatment for major depression that does not respond to standard first‐line therapies. The majority of data support the use of high‐frequency (10 Hz) treatment delivered to the left dorsolateral prefrontal cortex. Intermittent theta burst stimulation is a new emerging treatment that reduces the time required to deliver treatment and can increase capacity and access to this treatment. This review will comprehensively cover recent advancements in the field of rTMS for depression, including stimulation parameters and targets aimed at enhancing outcomes. In addition, efforts to use modern neuroscience tools to personalize this treatment and optimize outcomes will be reviewed.

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“…To this date, no published study has employed TMS‐EEG as a predictor and index of response to other rTMS protocols. However, using resting‐state EEG, a recent study by Noda et al . showed increases in synaptic plasticity and GABAergic activity after rTMS treatment in 31 patients with MDD, as measured by two EEG indexes of oscillatory activity.…”

Section: Major Depressive Disordermentioning

confidence: 99%

“…To this date, no published study has employed TMS-EEG as a predictor and index of response to other rTMS protocols. However, using resting-state EEG, a recent study by Noda et al 27 showed increases in synaptic plasticity and GABAergic activity after rTMS treatment in 31 patients with MDD, as measured by two EEG indexes of oscillatory activity. First, MDD patients showed increases in the power of resting gamma oscillations after rTMS, which are thought to be involved in several cognitive functions and are generated by GABA-A receptors.…”

Section: Prognostic and Predictive Purpose Of Biomarkersmentioning

confidence: 99%

The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry

Hui

Tremblay

Daskalakis

2019

Clin Pharma and Therapeutics

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The search for biological targets in psychiatric disorders is essential to better understand illness mechanisms and also to monitor and predict response to currently available therapeutic interventions. To this end, the combination of transcranial magnetic stimulation with electroencephalography (TMS‐EEG) has emerged as a powerful clinical research tool. TMS‐EEG allows cortical properties, such as excitability, inhibition, oscillatory activity, and connectivity, to be directly probed within a specific region of the cortex. This review will summarize the state of the current literature on TMS‐EEG and its potential to uncover biological targets in psychiatric illnesses, with a focus on major depressive disorder, bipolar disorder, and schizophrenia. Collectively, the reviewed studies suggest that alterations in gamma‐aminobutyric acid‐mediated inhibition and gamma oscillations in the dorsolateral prefrontal cortex and neighboring frontal regions are potential shared biomarkers in psychiatry, highlighting the potential of TMS‐EEG to help identify translational biomarkers.

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Resting-state EEG gamma power and theta–gamma coupling enhancement following high-frequency left dorsolateral prefrontal rTMS in patients with depression

Cited by 112 publications

References 78 publications

Assessing neurophysiological changes associated with combined transcranial direct current stimulation and cognitive emotional training for treatment-resistant depression

Assessing neurophysiological changes associated with combined transcranial direct current stimulation and cognitive emotional training for treatment-resistant depression

An Update on Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder

The Current and Future Potential of Transcranial Magnetic Stimulation With Electroencephalography in Psychiatry

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