Resting-state brain activity in Chinese boys with low functioning autism spectrum disorder

Li, Gaizhi; Rossbach, Kathryn; Jiang, Wenqing; Du, Yasong

doi:10.1186/s12991-018-0217-z

Cited by 21 publications

(22 citation statements)

References 30 publications

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“…ReHo is a method that uses Kendall’s coefficient of concordance (KCC) to measure the similarity of the time series of a given voxel with its 26 nearest neighbors in the brain. ReHo, which can reflect the strength of local spontaneous neural activity in the brain, was used in the study of ASD ( Paakki et al, 2010 ; Shukla et al, 2010 ; Itahashi et al, 2015 ; Li et al, 2018 ), but the results were heterogeneous. Jao Keehn et al (2019) also used the ReHo analysis and found that there was spontaneous nerve activity enhancement in the pericalcarine visual cortex in adolescent patients with ASD (8–18 years old).…”

Section: Introductionmentioning

confidence: 99%

Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders

Lan

et al. 2021

Front. Neurosci.

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ObjectivesThe study was aimed at investigating the alterations of local spontaneous brain activity in preschool boys with autism spectrum disorders (ASD).MethodsBased on regional homogeneity (ReHo), the acquired resting state functional magnetic resonance imaging (fMRI) data sets, which included 86 boys with ASD and 54 typically developing (TD) boys, were used to detect regional brain activity. Pearson correlation analysis was used to study the relationship between abnormal ReHo value and the Childhood Autism Rating Scale (CARS), Autism Behavior Checklist (ABC), developmental quotient, and age.ResultsIn the ASD group, we found increased ReHo in the right calcarine as well as decreased ReHo in the opercular part of the left inferior frontal gyrus, the left middle temporal gyrus, the left angular gyrus, and the right medial orbital frontal cortex (p < 0.05, false discovery rate correction). We did not find a correlation between the results of brain regions and the CARS, ABC, and age.ConclusionsOur study found spontaneous activity changes in multiple brain regions, especially the visual and language-related areas of ASD, that may help to further understand the clinical characteristics of boys with ASD.

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Section: Introductionmentioning

confidence: 99%

Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders

Lan

et al. 2021

Front. Neurosci.

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“…Individuals with ASD not only exhibited local underconnectivity in the right pMTG, but also showed a significant association between disrupted local connectivity in this region and social interaction [Itahashi et al, ]. However, increased degree centrality in the left MTG [Lee, Park, James, Kim, & Park, ] and increased amplitude of low‐frequency fluctuation in the right MTG [Li, Rossbach, Jiang, & Du, ] were identified in individuals with ASD. Although all these studies confirmed the dysfunctional activity of the MTG in ASD, the results are contradictory in terms of whether they showed hyperconnectivity or hypoconnectivity.…”

Section: Introductionmentioning

confidence: 99%

Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder

Wang

et al. 2019

Autism Research

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As one of the key regions in the “social brain” network, the middle temporal gyrus (MTG) has been widely reported to be associated with autism spectrum disorder (ASD), but there have been contradictory results in terms of whether it shows hyperconnectivity or hypoconnectivity. Delineating roles of MTG at the subregional level may eliminate the observed inconsistencies and provide a new avenue to reveal the neurophysiologic mechanism of ASD. Thus, we first performed connectivity‐based parcellation using the BrainMap database to identify fine‐grained functional topography of the MTG. Then, the MTG subregions were used to investigate differences in the functional connectivity in children and adults with ASD using two data sets from Autism Brain Imaging Data Exchange database. Four distinct subregions in the human left and right MTG were identified, including the anterior MTG (aMTG), middle‐anterior MTG (maMTG), middle‐posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with ASD than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD. Together, these results suggest a potential objective way to explore sub‐regional differences associated with such disorders. Autism Res 2020, 13: 410–422. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Four distinct subregions in the human left and right middle temporal gyrus (MTG) were identified, including the anterior MTG (aMTG), middle‐anterior MTG (maMTG), middle‐posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with autism spectrum disorder (ASD) than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD.

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“… 49 It has been widely used in clinical and scientific research, now being one of the most mature rating scales for domestic use. 50 …”

Section: Methodsmentioning

confidence: 99%

Abnormalities of Gray Matter Volume and Its Correlation with Clinical Symptoms in Adolescents with High-Functioning Autism Spectrum Disorder

Zhao

Zhu

Cao

et al. 2022

NDT

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Background Previous studies have indicated abnormal gray matter volume (GMV) in individuals with autism spectrum disorder (ASD); however, there is little consistency across the findings within these studies, partly due to small sample size and great heterogeneity among participants between studies. Additionally, few studies have explored the correlation between clinical symptoms and GMV abnormalities in individuals with ASD. Here, the current study examined GMV alterations in whole brain and their correlations with clinical symptoms in a relatively large and homogeneous sample of participants with ASD matched typically developing (TD) controls. Methods Forty-eight adolescents with high-functioning ASD and 29 group-matched TD controls underwent structural magnetic resonance images. Voxel-based morphometry was applied to investigate regional GMV alterations. The participants with ASD were examined for the severity of clinical symptoms with Autism Behavior Checklist (ABC). The relationship between GMV abnormalities and clinical symptoms was explored in ASD group using voxel-wise correlation analysis within brain regions that showed significant GMV alterations in individuals with ASD compared with TD controls. Results We found increased GMV in multiple brain regions, including the inferior frontal gyrus, medial frontal gyrus, superior frontal gyrus, superior temporal gyrus, occipital pole, anterior cingulate, cerebellum anterior lobe, cerebellum posterior lobe, and midbrain, as well as decreased GMV in cerebellum posterior lobe in individuals with ASD. The correlation analysis showed the GMV in the left fusiform was negatively associated with the scores of sensory factor, and the GMV in the right cerebellum anterior lobe was positively associated with the scores of social self-help factor. Conclusion Our results indicated that widespread GMV abnormalities of brain regions occurred in individuals with ASD, suggesting a potential neural basis for the pathogenesis and symptomatology of ASD.

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Resting-state brain activity in Chinese boys with low functioning autism spectrum disorder

Cited by 21 publications

References 30 publications

Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders

Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders

Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder

Abnormalities of Gray Matter Volume and Its Correlation with Clinical Symptoms in Adolescents with High-Functioning Autism Spectrum Disorder

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