Resting frontal EEG asymmetry patterns in adolescents with and without major depression

Grünewald, Barbara; Greimel, Ellen; Trinkl, Monika; Bartling, Jürgen; Großheinrich, Nicola; Schulte‐Körne, Gerd

doi:10.1016/j.biopsycho.2018.01.003

Cited by 41 publications

(28 citation statements)

References 27 publications

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“…Relations between structural and functional variability of the brain are subtle and complex (34)(35)(36)(37). As mentioned in the introduction, various studies of depression have reported case-control differences in the asymmetry of frontal electrophysiological patterns (11,14). The number of pyramidal cells, the number of synapses per cell, and their firing patterns are thought to influence cortical EEG recordings (38).…”

Section: Discussionmentioning

confidence: 99%

“…There are indications that altered brain asymmetry may also play a role in major depression. On a functional level, EEG studies have reported that asymmetry in frontal brain resting activity differs between individuals with major depression and healthy control subjects, although not always in a consistent direction, and is moderated by age and sex (see, e.g., [11][12][13][14]; reviewed in 15,16). Such findings have led to the development of stimulation protocols targeting the left dorsolateral prefrontal cortex, which are now used in the clinic for the treatment of major depression (17).…”

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confidence: 99%

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No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

Kovel

Aftanas

Alemán

et al. 2019

AJP

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Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T 1-weighted MRI data were processed with a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

Kovel

Aftanas

Alemán

et al. 2019

AJP

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“…Cross-sectionally, several studies showed that FAA is independent of depression severity, both between patients (Allen et al, 2004;Arns et al, 2016;Feldmann et al, 2018;Gollan et al, 2014;Nusslock et al, 2018;Van der Vinne et al, 2017;Vuga et al, 2006) and within patients, including remission (Carvalho et al, 2011). This contrasts the findings by Grünewald et al (2018) and Keune et al (2011), where a higher level of depression complaints correlated with more left-sided FAA (albeit only in the control group of Grünewald et al). In other cross-sectional studies on FAA stability between depressed patients and patients remitted from depression, no differences were found (Carvalho et al, 2011;Feldmann et al, 2018;Gotlib et al, 1998).…”

Section: Introductioncontrasting

confidence: 79%

“…We hypothesized that analysis of week-8 medicated EEG data would result in the same treatment prediction results as baseline unmedicated data did. Bruder et al, 2008Debener et al, 2000Deldin & Chiu, 2005Gollan et al, 2014Keune et al, 2011Spronk et al, 2008Vuga et al, 2006Davidson et al, 2003Hagemann, et al, 2002Hagemann, et al, 2005³ Sutton & Davidson, 1997Tenke et al, 2017³ Tomarken et al, 1992Carvalho et al, 2011Feldmann et al, 2018Gotlib et al, 1998Grünewald et al, 2018Nusslock et al, 2018 3.2 METHODS AND MATERIALS…”

Section: Introductionmentioning

confidence: 99%

EEG biomarkers in depression: paving the way for stratified psychiatry

Vinne¹

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“…There is empirical support in adolescent populations for a biological model explaining depression (Grünewald et al, ; Mitchell & Pössel, ; Stewart & Allen, ; Tomarken, Dichter, Garber, & Simien, ) by focusing on the regulation of emotion and electroencephalographic (EEG) activity in the frontal cortex (Davidson, ). This model predicts that withdrawal‐related negative emotions such as fear and disgust are linked to relative hyperactivity of the right frontal hemisphere, whereas approach‐related positive emotions such as pride and enthusiasm are associated with hypoactivity of the right frontal hemisphere.…”

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Does frontal brain activity mediate the effect of depression prevention in adolescents? A pilot study

2019

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W e investigated whether (a) depression prevention was associated with depressive symptoms and medial-frontal alpha asymmetry in adolescents; (b) alpha asymmetry mediated the association between participation in a prevention program and depressive symptoms; and (c) gender affects these associations. In our randomised control group study, we compared a universal prevention program (n = 40 adolescents, 14 females) with a non-intervention control condition (n = 39 adolescents, 20 females) in German secondary school students (mean age: 13.53 years, SD = 0.53). We collected data at baseline, post-intervention, 6-month, and 12-month follow-up using the Self-Rating Questionnaire for Depressive Disorders (SBB-DES) and resting medial-frontal alpha activity on F3 and F4. We found that girls benefitted from participating in the prevention program in regards to their depressive symptoms at 12-month follow-up but not alpha asymmetry. In boys, participation in the prevention program was associated with their alpha asymmetry at 6-month follow-up but not their depressive symptoms. Alpha asymmetry did not mediate the effects of the prevention program on depressive symptoms in either gender. Although participation in the prevention program was associated with both depressive symptoms and alpha asymmetry, those associations seem independent from each other. Possible explanations for this result pattern are discussed.

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Resting frontal EEG asymmetry patterns in adolescents with and without major depression

Cited by 41 publications

References 27 publications

No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis

EEG biomarkers in depression: paving the way for stratified psychiatry

Does frontal brain activity mediate the effect of depression prevention in adolescents? A pilot study

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