Resting energy expenditure in cancer patients: Agreement between predictive equations and indirect calorimetry

Barcellos, P.S.; Borges, Nuno; Torres, Duarte

doi:10.1016/j.clnesp.2021.01.019

Cited by 9 publications

(4 citation statements)

References 46 publications

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“…Several studies [ 42 , 43 , 44 , 45 , 46 ] emphasize the importance of indirect calorimetry as the goal standard in evaluating the real energy requirements in cancer patients. Predictive formulas, such as the Harris–Benedict equation, do not consider the cancer energy expenditure, underestimating the real REE of the patient [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Home Artificial Nutrition and Energy Balance in Cancer Patients: Nutritional and Clinical Outcomes

et al. 2022

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Malnutrition is one of the main factors determining cachexia syndrome, which negatively impacts the quality of life and survival. In cancer patients, artificial nutrition is considered as an appropriate therapy when the impossibility of an adequate oral intake worsened nutritional and clinical conditions. This study aims to verify, in a home palliative care setting for cancer patients, if home artificial nutrition (HAN) supplies a patient’s energy requirement, improving nutritional and performance status. A nutritional service team performed counseling at a patient’s home and assessed nutritional status (body mass index, weight loss in the past 6 months), resting energy expenditure (REE), and oral food intake; Karnofsky Performance Status (KPS); cachexia degree; and survival. From 1990 to 2021, 1063 patients started HAN. Among these patients, 101 suspended artificial nutrition for oral refeeding. Among the 962 patients continuing HAN until death, 226 patients (23.5%) survived 6 weeks or less. HAN allowed to achieve a positive energy balance in 736 patients who survived more than 6 weeks, improving body weight and KPS when evaluated after 1 month of HAN. Advanced cancer and cachexia degree at the entry of the study negatively affected the positive impact of HAN.

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Section: Discussionmentioning

confidence: 99%

Home Artificial Nutrition and Energy Balance in Cancer Patients: Nutritional and Clinical Outcomes

et al. 2022

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“…A common finding, especially with advanced cancer, is a reduction in appetite. Among the causes of cancer cachexia includes damage to normal body tissues with subsequent inflammation, decreased hunger, increased energy expenditure, and dysmetabolism (i.e., proteolysis, lipolysis) [ 31 , 32 ]. One of the more identified pro-inflammatory factors associated with cancer is tumor necrosis factor (TNF), which is a cytokine that promotes tumorigenesis via stimulation of cancer cell growth, tumor angiogenesis, proliferation, invasion, and metastasis.…”

Section: Obesity and Cancer: Genetics And Epigeneticsmentioning

confidence: 99%

Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022

Lazarus

Bays²

2022

Obesity Pillars

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“…In this regard, repeated measurements of REE in combination with body composition analysis over the course of different illness trajectories have provided more insight in metabolic alterations, as dynamic patterns were unraveled suggested to correspond with illness progression or resolution (15)(16)(17)(18). The use of IC to measure REE is therefore preferred over pREE to accurately assess the metabolic demand and determine nutritional goals in patient populations (14).…”

Section: Introductionmentioning

confidence: 99%

“…In cancer, both an increase (hypermetabolism) and decrease (hypometabolism) in the level of REE can occur, as well as no change at all (14). The high variability is most likely due to the extensive range of clinical phenomena (cancer type, -stage, treatment, metabolic derangements) that can alter a patients' metabolic demand.…”

Section: Introductionmentioning

confidence: 99%

Resting energy expenditure, body composition, and metabolic alterations in breast cancer survivors vs. healthy controls: A cross-sectional study

Soom

Tjalma

Daele

et al. 2023

Preprint

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Purpose: This study aimed to investigate the difference in absolute and relative measured resting energy expenditure (mREE) and body composition (body weight, fat mass (FM), fat free mass (FFM)) between breast cancer survivors (BCs) and controls. Correlations with body composition were analyzed. We examined if survival year, the metabolic state, or being metabolically dysfunctional were confounding factors. Methods: A cross-sectional analysis was conducted on 32 BCs ≤5years post treatment and 36 healthy controls. Indirect calorimetry measured absolute mREE. Body composition was determined by BOD POD. Relative mREE was calculated (absolute mREE/FFM). The Harris-Benedict equation was used to predict REE and determine the metabolic state (mREE/pREE). The database of the multidisciplinary breast clinic of the University Hospital of Antwerp was consulted for survival year and metabolic dysfunctions. Results: BCs have similar absolute mREE and greater relative mREE compared to controls with similar body composition. Absolute mREE and body composition between BCs differed; relative mREE was similar. FFM correlated significantly with absolute and relative mREE in BCs. A significant interaction term was found between survival year and FM for absolute mREE. The metabolic state was a significant contributor to absolute and relative mREE. Conclusion: BCs have similar or higher mREE. Differences in body composition between BCs are suggested to cause inter-individual variations in absolute mREE. We hypothesize that increased energy requirements are caused by metabolic stress related to cancer/treatment. Accurate measurement of REE and body composition is advised when adapting nutritional strategies, especially in patients at risk for developing metabolic dysfunctions.

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Resting energy expenditure in cancer patients: Agreement between predictive equations and indirect calorimetry

Cited by 9 publications

References 46 publications

Home Artificial Nutrition and Energy Balance in Cancer Patients: Nutritional and Clinical Outcomes

Home Artificial Nutrition and Energy Balance in Cancer Patients: Nutritional and Clinical Outcomes

Cancer and Obesity: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022

Resting energy expenditure, body composition, and metabolic alterations in breast cancer survivors vs. healthy controls: A cross-sectional study

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