Rest energy expenditure in Parkinson's disease: Role of disease progression and dopaminergic therapy

Capecci, Marianna; Petrelli, Massimiliano; Emanuelli, B.; Millevolte, Marzia; Nicolai, Albano; Provinciali, Leandro; Ceravolo, Maria Gabriella

doi:10.1016/j.parkreldis.2012.10.016

Cited by 38 publications

(29 citation statements)

References 28 publications

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“…These results are not easy to explain and have not been replicated. Our results further suggest that hyposmia does not affect body weight, while other factors commonly associated with hyposmia, such as PD severity or longer disease duration 7, 8 were indirectly related to body weight.…”

Section: Discussionsupporting

confidence: 67%

“…2–6 Previous studies have attempted to identify primary mechanisms involved in this multifactorial process, including motor and non-motor symptoms influencing energy balance, ultimately affecting body weight. Long disease duration, 7 disease severity, 8 and female gender 9 appear to be established body weight determinants. In addition, olfactory dysfunction, 10 dysphagia, impaired hand–mouth coordination, 11 decreased cognitive function, 9, 12 altered neuroendocrine regulation of appetite, 13 reduced leptine levels, 5 intestinal dysmotility, and Levodopa side effects, 14, 15 have also been related to inadequate energy intake; whereas raised metabolic rate at rest 7 has been linked to enhanced muscle activity due to tremor, rigidity or dyskinesia which may contribute to increase energy expenditure.…”

Section: Introductionmentioning

confidence: 99%

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A multifactorial study on nutritional status, binge eating and physical activity as main factors directly influencing body weight in Parkinson’s disease

Bril

Pérez-Lloret

Rossi

et al. 2017

npj Parkinson's Disease

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Weight lossisa multifactorial disorder commonly affecting Parkinson’s disease patients. The aim of this study was to investigate the relationship between body weight, nutritional status, physical activity, and Parkinson’s disease-related factors. A total of 114 consecutive Parkinson’s disease patients without dietary restrictions were evaluated prospectively with respect to: nutritional status (Mini Nutritional Assessment), physical activity level (Yale Physical Activity Survey), MDS-UPDRS score, olfactory function, depression, cognitive functionand impulse-control disorders, among other variables. Structural equation modeling was used to build multivariate models and to calculate standardized regression weights (srw) for pairs of variables, which are homologous to correlation coefficients, taking into account the effects of all other variables in the model. Sixty (53%) patients were males. Mean age was 66.1 ± 9.8 years and mean disease duration was 8.3 ± 5.6 years. Longer disease duration was negatively related to nutritional status (srw = −0.25; p = 0.01). UPDRS II + III score was associated with reduced cognitive function (srw = −0.39; p = 0.01), which was positivelyrelated to nutritional status (srw = 0.23; p = 0.01). Finally, nutritional status was positively related to body weight (srw = 0.22, p < 0.01). Binge eating and physical activity were also directly and positively related to body weight (srw = 0.32; p = 0.001 and srw = 0.23; p = 0.001). Nutritional status, binge eating and physical activity were directly and independently related to body weight in our sample of Parkinson’s disease patients. Therefore, physicians should actively explore nutritional status and binge eating in Parkinson’s disease patients to avoid alterations in body weight regulation. Effects of physical activity should be further explored.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

A multifactorial study on nutritional status, binge eating and physical activity as main factors directly influencing body weight in Parkinson’s disease

Bril

Pérez-Lloret

Rossi

et al. 2017

npj Parkinson's Disease

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show abstract

“…This creates a strong interaction between medication and nutrients resulting in impairment of the motor fluctuations of the patient. 7,[35][36][37][38] Of the studied population, 75.0% ingested their levodopa based medication at the same time as their meals, not following the recommended interval.…”

Section: 34mentioning

confidence: 99%

Avaliação nutricional e o uso da levodopa com refeições proteicas em pacientes com doença de Parkinson do município de Macaé, Rio de Janeiro

Carmo

Ferreira

2016

Rev. bras. geriatr. gerontol.

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Parkinson's disease (PD) is characterized by a reduction in dopamine in the central nervous system. It has a gradual progression, and is mainly known for causing tremors and difficulty in performing movements. Studies have shown that there is a significant change in the nutritional status of patients with PD. The main medication used in the treatment of patients is levodopa, and its use, without respecting the minimum intervals of 30 minutes before or one hour after meals, may diminish the pharmacological effect of the drug because of drug-nutrient interactions. The present study aimed to identify PD patients at nutritional and protein consumption risk associated with the use of levodopa in the city of Macaé. A cross-sectional quantitative and descriptive study was performed. The instruments used were the Mini Nutritional Assessment (MNA) and an estimated 3-day dietary record. The analysis was descriptive. To form the sample population a survey was performed of patients diagnosed with PD in two Department of Health programs and from the Parkinson's Association of Macaé. A total of 40 individuals were evaluated, of whom 57.5% were male. Of these, 62.5% presented a risk of malnutrition or MNA defined malnutrition, with nutritional deficit. The protein intake of the study population was 1.4 g/kg/day. The highest protein intake was during the day, including the meals between breakfast and the afternoon snack. A total of 74.7% of total protein was consumed by the population during this period. Overall, 75.0% of the elderly persons consumed their medications containing levodopa simultaneously with meals or did not follow the interval recommended by ANVISA. The study found that the total daily intake of most individuals was hyper-proteic, with proteic content being poorly distributed among meals throughout the day, and that they did not follow the recommended levodopa interval.

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“…Thus, this 'hyperactive' symptom would also be expected to increase overall energy expenditure. A study by Capecci et al [5] examined 58 PD subjects, after excluding conditions known to influence metabolism (i.e., dysphagia, severe tremor, etc. ), subjects underwent resting energy expenditure measurements via indirect calorimetry during ON and OFF dopaminergic treatment (generally OFF referes to a minimum 12-hour withdrawal from dopaminergic medication).…”

Section: The Cyclical Nature Of Secondary Cardiometabolic Disease In mentioning

confidence: 99%

Cardiometabolic Disease in Parkinson’s Disease High or Low Risk — A Risk Worth Protecting?

Almeida

2014

Curr Cardiovasc Risk Rep

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Parkinson's disease (PD) is the most common neurodegenenerative movement disorder known to man, representing a number of Parkinsonian syndromes whose sufferers are faced with similar symptomatology and challenges to mobility, independence and quality of life. With a growing aged population, and no cure for PD, it has become increasingly important to identify risk factors (and approaches to modifying these risk factors) that contribute to morbidity in these populations. This article considers the cyclical nature of whether the cardinal symptoms of PD lead to cardiometabolic decline, or whether the factors that are associated with cardiometabolic disease put people at higher risk for developing PD. Then, we examine the risk of developing cardiometabolic disease in PD compared to the general population. Finally, interventions and physical activity recommendations are reviewed, as well as healthcare management strategies to protect from cardiometabolic disease in PD. These recommendations are likely applicable to other Parkinsonian movement disorders as well.

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Rest energy expenditure in Parkinson's disease: Role of disease progression and dopaminergic therapy

Cited by 38 publications

References 28 publications

A multifactorial study on nutritional status, binge eating and physical activity as main factors directly influencing body weight in Parkinson’s disease

A multifactorial study on nutritional status, binge eating and physical activity as main factors directly influencing body weight in Parkinson’s disease

Avaliação nutricional e o uso da levodopa com refeições proteicas em pacientes com doença de Parkinson do município de Macaé, Rio de Janeiro

Cardiometabolic Disease in Parkinson’s Disease High or Low Risk — A Risk Worth Protecting?

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