Responsiveness of the Ovary to Gonadotrophins in Pre- And Perinatal Life: Oestrogen Secretion in Tissue and Organ Cultures

Levina, S. E.; Gyévai, A; Horvath, Edit

doi:10.1677/joe.0.0650219

Cited by 14 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recent serum and tissue analyses from newborn rats and mice have revealed increases in ovarian estrogen in response to hCG (human chorionic gonadotropin), LH, FSH, and cAMP (cyclic adenosine 3Ј,5Ј-monophosphate) around 1 week after parturition (Mannan & O'Shaughnessy 1991;Sokka & Huhtaniemi 1995;Weniger et al 1993). Ovarian hypertrophy in response to unilateral gonadectomy has been observed as early as Day 10 in the rat (Gerall & Dunlap 1971), and estrogen synthesis has been observed in neonatal ovarian tissue cultured in vitro (Funkenstein et al 1980;Levina et al 1975). These findings support the view that ovarian estrogen could exert developmental effects in the neonatal period following the decline of AFP.…”

Section: Onset Of Ovarian Activitymentioning

confidence: 99%

A role for ovarian hormones in sexual differentiation of the brain

Fitch¹,

Denenberg²

1998

Behav Brain Sci

159

View full text Add to dashboard Cite

Historically, studies of the role of endogenous hormones in developmental differentiation of the sexes have suggested that mammalian sexual differentiation is mediated primarily by testicular androgens, and that exposure to androgens in early life leads to a male brain as defined by neuroanatomy and behavior. The female brain has been assumed to develop via a hormonal default mechanism, in the absence of androgen or other hormones. Ovarian hormones have significant effects on the development of a sexually dimorphic cortical structure, the corpus callosum, which is larger in male than in female rats. In the females, removal of the ovaries as late as Day 16 increases the cross-sectional area of the adult corpus callosum. Treatment with low-dose estradiol starting on Day 25 inhibits this effect. Female callosa are also enlarged by a combination of daily postnatal handling and exogenous testosterone administered prior to Day 8. The effects of androgen treatment are expressed early in development, with males and testosterone-treated females having larger callosa than control females as early as Day 30. The effects of ovariectomy do not appear until after Day 55. These findings are more consistent with other evidence of a later sensitive period for ovarian feminization as compared to androgenic masculinization.

show abstract

Section: Onset Of Ovarian Activitymentioning

confidence: 99%

A role for ovarian hormones in sexual differentiation of the brain

Fitch¹,

Denenberg²

1998

Behav Brain Sci

159

View full text Add to dashboard Cite

show abstract

“…Although it has been shown in tissue culture that rat ovaries do not produce oestrogen after HCG stimulation (Levina et al, 1975), fetal ovaries do possess the enzymes required for steroidogenesis, and can respond to stimulation by prostaglandin PGE, with increased CAMP formation (Lamprecht et al, 1973). On the whole the role of pituitary secretion in ovarian endocrine function in utero seems limited.…”

Section: Gonadal F U N C T I O N I N T H E Fetusmentioning

confidence: 99%

Hypothalamic‐pituitary‐gonadal Relationships in Man From Birth to Puberty

Forest

Peretti

Bertrand

1976

Clinical Endocrinology

134

View full text Add to dashboard Cite

Gonadal function depends upon activities at various levels. Thus there is: (a) a central level (extra-hypothalamic, hypothalamic, and anterior pituitary); (b) an intermediate level (gonadal and plasma), and (c) a peripheral level consisting of the target organs to which the hormonal message is directed. These determine both the expression of gonadal function (physical, physiological, or psychological) and the feedback regulation of the secretion of gonadotrophins.(a) Central level (i) Extra-hypothalamic centres. The production of LH releasing hormone (LHRH) is affected in the rat, and probably in primates as well, by extra-hypothalamic stimuli coming, in particular, from the amygdala and the hippocampus. Adrenergic regulation exists at this level, noradrenaline having a stimulatory and dopamine an inhibitory effect (Bliss et al., 1972).(ii) Hypothalamic centres. These are localized in particular in the pre-optic area. Immunochemical techniques have demonstrated that LHRH is secreted by neurones of the arcuate nucleus, and released into the capillary plexus proximal to the hypophyseal portal system at the level of the median eminence, thereby reaching the anterior pituitary (Barry & Dubois, 1974;Setalo et al., 1975).(iii) Gonadotrophin secreting cells of the anterior pituitary. These synthesize and secrete the gonadotrophins, LH and FSH, under the influence of LHRH (Schally et al., 1972). The pituitary gonadotrophins stimulate the synthesis and the secretion of the gonadal

show abstract

“…The state of vaginal smears and ovarian histology appear to indicate that hOG-primed mice undergo a slight degree of persistent-estrus syndrome. Levina et al (1975) have reported that secretion of estrogen by the ovaries of fetal rats was not detectable from days 15 to 19 of gestation. Presl et al (1969) have demonstrated the presence of estrogen in the blood of normal rats only when the animals attained the age of 8 days.…”

Section: Discussionmentioning

confidence: 99%

Changes in Gonads of Male and Female Offspring of Mice Receiving a Continuous Intravenous Infusion of Human Chorionic Gonadotropin during Gestation

Takasugi¹,

Iguchi²,

Kurihara³

et al. 2009

Exp Clin Endocrinol Diabetes

View full text Add to dashboard Cite

In male offspring of mice given a continuous intravenous infusion of 24 IU/day hCG from days 15 to 19 of gestation (hCG-primed mice), the number of Leydig cells/testis at 15 days of age was similar to the value at 10 days, whereas the cells were decreased in number in the controls at 15 days. Mitotic rate of the interstitial tissue in 30-day-old, hCG-primed mice was lower than in the controls. In seminiferous tubules of hCG-primed mice, intratubular spaces were formed at 15 days, while the spaces in the controls were observed at 30 days. Various disorganization of the germinal epithelium occurred in some tubules of hCG-primed mice at 30-90 days. Spermatogenesis was impaired in the damaged tubules. Female hCG-primed mice showed a slightly longer estrus (24 IU/day), a higher frequency of estrus and larger number of total estrus days (120 IU/day) than those in the controls. Ovaries of 160-day-old, hCG-primed mice (24 IU/day) contained normal follicles more than those in the controls. Corpora lutea decreased in number in both groups of hCG-primed mice, showing a lower corpus-luteum occupancy. These findings suggest the occurrence of a slight degree of persistent-estrus syndrome in hCG-primed female mice.

show abstract

Responsiveness of the Ovary to Gonadotrophins in Pre- And Perinatal Life: Oestrogen Secretion in Tissue and Organ Cultures

Cited by 14 publications

References 7 publications

A role for ovarian hormones in sexual differentiation of the brain

A role for ovarian hormones in sexual differentiation of the brain

Hypothalamic‐pituitary‐gonadal Relationships in Man From Birth to Puberty

Changes in Gonads of Male and Female Offspring of Mice Receiving a Continuous Intravenous Infusion of Human Chorionic Gonadotropin during Gestation

Contact Info

Product

Resources

About