Responses to saline drinking water in offspring born to ewes fed high salt during pregnancy

Digby, S.N.; Blache, Dominique; Masters, DG; Revell, Dean

doi:10.1016/j.smallrumres.2009.11.020

Cited by 15 publications

(11 citation statements)

References 28 publications

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“…Furthermore, leptin concentrations are lower in offspring born to ewes fed high salt during pregnancy, suggesting not only an increase in energy expenditure and a mobilization of energy reserves in response to ingestion of saline water but also an effect of 'salt programming' on leptin. This is very interesting because previous studies have suggested that leptin is not affected by fetal programming from salt ingestion (Blache et al, 2007b;Digby et al, 2008Digby et al, , 2010aDigby et al, and 2010b.…”

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 79%

“…Salt excretion, urinary output and aldosterone concentration were similar between both groups on day 1 (Figure 2). However, by day 2, urinary output and sodium excretion and, aldosterone secretion decreased, in lambs born to ewes fed high salt during pregnancy, while they remained unchanged in control lambs (Figure 2 adapted from Digby et al, 2010b). Those modifications illustrate the programmed adaption to a load of ingested salt.…”

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 95%

“…In offspring born to ewes fed high salt during pregnancy, voluntary feed intake was , 35% less than controls when consuming 1.3% saline water for 2 days (Digby et al, 2010b). In addition, the secretion of insulin in both groups of offspring suggested that the energy balance of the lambs, defined as the difference between energy expenditure and the sum of energy intake and energy reserves, had drifted toward a negative value because of the decrease in feed intake (Blache et al, 2007b).…”

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 96%

“…In addition, the plasma concentration of AVP was lower in high-salt offspring, suggesting that the sensitivity of the kidney to changes in osmotic pressure was reduced in offspring born to ewes fed high salt during pregnancy (Digby et al, 2010a). These results combined with those of Desai et al (2003) suggest that the AVP threshold was altered in offspring in response to changes in water balance or salt Figure 2 Daily mean saline water intake, urinary output, sodium excretion and plasma aldosterone area under the curve (AUC) of lambs born of mother fed to high NaCl diet (15%) during pregnancy (S lambs; open bars) for lambs born of mother not fed to low NaCl diet (0.9%) during pregnancy (C lambs; black bars) and consuming saline water for 2 days (adapted from Digby et al, 2010b). *Denotes significant difference from day 1 (P , 0.05).…”

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 99%

“…Furthermore, offspring born to ewes fed high salt during pregnancy, presented a modified temporal pattern of hormone secretion when consuming saline water for 2 days (Digby et al, 2010b). Initially, water intake was lower in the offspring born to dams fed high salt during pregnancy, but there was a degree of correction on the second day, such that total water intake did not differ over the 2 days.…”

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 99%

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Salt intake and reproductive function in sheep

Digby

Chadwick

Blache

2011

Animal

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Producers have the possibility to combat human-induced dryland salinity by planting salt-tolerant plants such as saltbush. Saltbush has the potential to be used as a source of food for livestock at a time and place where pasture is not viable. However, saltbush contains high concentrations of sodium chloride salt and some other anti-nutritional factors that have the potential to affect feed and water intake and, directly or indirectly, the reproductive capacity of sheep. High-salt diet during gestation induces a small modification of the activity of the renin-angiotensin system (RAS) that has an important role in the maintenance of the salt-water balance in non-pregnant and pregnant sheep. In contrast, the main effect of salt ingestion during pregnancy is observed on the biology of the offspring, with changes in the response of the RAS to salt ingestion and altered thirst threshold in response to an oral salt ingestion. These changes, observed later in life, are the result of fetal programming following the ingestion of salt by the mother. It seems that the exposure to salt during pregnancy could provide an advantage to the offspring because of this adaptive response. The response may be particularly useful, for example, when grazing herbivores are fed halophytic forages adapted to saline soils.

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Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 79%

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 95%

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 96%

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 99%

Section: Fetal Programming During Intra-utero Exposure To Saltmentioning

confidence: 99%

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Salt intake and reproductive function in sheep

Digby

Chadwick

Blache

2011

Animal

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An Australasian Perspective on the Role of Reproductive Technologies in World Food Production

Martin

2013

Current and Future Reproductive Technologies and World Food Production

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Industries based on small ruminants are major contributors to world food supply but, in extensive grazing systems, reproductive technology is not directly relevant to most enterprises. More important is the need to respond to demand in high-profit export markets for products that are 'clean, green and ethical' (CGE). This combination of issues led to the concept of CGE management of reproduction that is based on scientific evidence but does not require complex technology. Nutrition is the major challenge because we are limited primarily to the grazing of forages and pastures, but responding to this challenge opens up opportunities-new forages can supply energy and protein whilst improving animal health and welfare, and reducing carbon emissions. A second major factor is the need for accurate coordination of nutritional inputs with reproductive events to ensure that the metabolic signals are appropriate. To control of the timing of reproduction, we need to move beyond simply managing the presence of the male and seek more precision. Our ultimate CGE package is thus based on manipulation of male socio-sexual signals as well as nutrition, in combination with greater use of ultrasound and birth-site management to prevent neonatal mortality. Finally, genetics is critical in the development of the CGE package.It would be difficult to incorporate the entire package in one hit-adaptations are needed to cover variations in genotype and the geographical and socio-economic environment, and some concepts need research and development. Therefore, we have suggested staged introduction of the elements of the package.CGE management can be simple and cost-effective, and improve productivity whilst safeguarding the future of the industries in society and the marketplace. Reproductive technology might not be used by many farmers but it will be an essential tool for realizing the vision because it underpins the acceleration of genetic progress in otherwise tardy grazing industries. Finally, we suggest that the socio-economic drivers and the scientific principles of CGE management are also applicable to smallholders in developing economies.

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