Responses of the Superficial Portion of the Human Pilosebaceous Apparatus to Controlled Injury1

Eisen, Arthur Z.; Holyoke, John B.; Lobitz, Walter C.

doi:10.1038/jid.1955.112

Cited by 90 publications

(28 citation statements)

References 11 publications

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“…The SD is a transitional zone between infundibulum (interfollicular epidermis) and sebocytes, suggesting that a bimodality of these cells to differentiate into both directions exists [56]. In wounds, undifferentiated ductal cells migrate to the surface and differentiate into epidermal keratinocytes, and some undergo conversion into sebocytes [57]. A recent study identified keratin 6 as a marker of duct fate in SGs [58].…”

Section: Sebaceous Duct (Sd) Cells Are Bimodal Epithelial Cellsmentioning

confidence: 99%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

116

112

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The sebaceous gland is mostly found in association with a hair follicle. Its traditional function is the holocrine production of sebum, a complex mixture of lipids, cell debris, and other rather poorly characterized substances. Due to the gland central role in acne pathogenesis, early research had focused on its lipogenic activity. Less-studied aspects of the sebaceous gland, such as stem cell biology, the regulation of cellular differentiation by transcription factors, the significance of specific lipid fractions, the endocrine and specially the neuroendocrine role of the sebaceous gland, and its contribution to the innate immunity, the detoxification of the skin and skin aging have recently attracted the attention of researchers from different disciplines. Here, we summarize recent, multidisciplinary progress in sebaceous gland research and discuss how sebaceous gland research may stimulate the development of novel therapeutic strategies targeting specific molecular pathways of the pathogenesis of skin diseases.

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Section: Sebaceous Duct (Sd) Cells Are Bimodal Epithelial Cellsmentioning

confidence: 99%

Beyond acne: Current aspects of sebaceous gland biology and function

Zouboulis¹,

Picardo

Qiang

et al. 2016

Rev Endocr Metab Disord

116

112

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“…The pilosebaceous unit is a dynamic structure constantly undergoing cyclic change and endowed with considerable regenerative capacity as seen in wound healing [12] or following partial destruction [15], It sometimes even eliminates its own components in the so-called alarm reaction [20]. Transfollicular extrusion of sebaceous glands was also observed [28], Its participation in the excretion of the foreign material from the dermis was demonstrated experimentally using charcoal particles [7].…”

Section: Discussionmentioning

confidence: 99%

Granuloma annulare with Follicular Perforation

Bardach¹

1982

Dermatology

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An instance of perforating granuloma annulare was observed in a 42-year-old female patient in which the necrobiotic material in the dermis was eliminated by a hair follicle. This had previously been described by the author in only 1 other case of perforating granuloma annulare. Transepithelial elimination may occur by the transepidermal and/or transfollicular route. Both pathways are possible in perforating granuloma annulare. Some factors are discussed which may be responsible for the predominance of one route over the other in various disorders of transepithelial elimination.

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“…In order to further elucidate the molecular basis of these effects, and to verify these data in early passage human keratinocytes, we studied the effects of various biotin concentrations on proliferation, differentiation and keratin expression of outer root sheath (ORS) cells from human hair follicles. It is well known that the cells from the ORS tissue can differentiate towards interfollicular epidermal keratinocytes, as during wound healing, where they migrate out of the ORS to cover the denuded area [2,11]. Moreover, experiments in the rate have demonstrated that ORS cells have the potential to regenerate the hair matrix (i.e.…”

Section: Introductionmentioning

confidence: 97%

Proliferation and differentiation of cultured human follicular keratinocytes are not influenced by biotin

et al. 1996

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In humans and in animals, biotin deficiency causes pathological changes in the skin and its appendages. High doses of biotin may also have beneficial effects on skin, hair and fingernails in humans and animals with normal biotin status. Therefore, we investigated the effects of low and high concentrations of biotin on proliferation and differentiation of cultured outer root sheath cells from human hair follicles as an in vitro model for skin. The activities of biotin-dependent carboxylases were measured to evaluate the biotin status of the cells. In monolayer cultures of outer root sheath cells, proliferation and expression of the differentiation-specific keratins K1 and K10 were not influenced by extremely low concentrations of biotin (<2 x 10(-10) mol/l) or by pharmacological doses of biotin (10(-5) mol/l). Biotin deficiency of the cells was confirmed under the former condition by demonstrating decreased activities of the mitochondrial carboxylases. In organotypic cocultures of outer root sheath cells and dermal fibroblasts, in which stratified epithelia resembling epidermis were developed, the biotin concentration had no effect on the expression of all tested epidermal differentiation markers, including the suprabasal keratins K1 and K10, the hyperproliferation-associated keratin K16, involucrin and filaggrin.

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Responses of the Superficial Portion of the Human Pilosebaceous Apparatus to Controlled Injury1

Cited by 90 publications

References 11 publications

Beyond acne: Current aspects of sebaceous gland biology and function

Beyond acne: Current aspects of sebaceous gland biology and function

Granuloma annulare with Follicular Perforation

Proliferation and differentiation of cultured human follicular keratinocytes are not influenced by biotin

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