Granuloma annulare with Follicular Perforation

Bardach, H

doi:10.1159/000249919

Cited by 18 publications

(5 citation statements)

References 7 publications

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“…[17][18][19] In the second way, necrobiotic collagen breaks hair follicle wall, causing anexal destruction. 20 The entire process is allowed thanks the inflammation of abnormal dermal components ( collagen, elastin or even cholesterol crystals). 13,15 Clinically lesions begin with asymptomatic erythematous plaques, with raised dusky red border, with slow growth and outer comedo-like lesions which leave a crater like depression when are removed (transfollicular elimination) or with kyperkeratotic papules (transepidermal elimination).…”

Section: Discussionmentioning

confidence: 99%

Case number 19th of perforating necrobiosis lipoidica worldwide

calle¹

2018

MOJBM

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Perforating necrobiosis lipoidica is a secondary perforating disease with necrobiotic collagen elimination through the epidermis in diabetic patients. Lesions are very similar to classic necrobiosis lipoidica but in the former there are keratotic plugs over the raised borders of the atrophic yellow plaques. It is explained by necrotic collagen on upper dermis causing inflammation and breaking on through the hair follicle wall or abnormal channels connecting dermis with the outside. In spite of its low frequency, this manuscript highlights the first case reported in Colombia, the 19 th case worldwide.

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Section: Discussionmentioning

confidence: 99%

Case number 19th of perforating necrobiosis lipoidica worldwide

calle¹

2018

MOJBM

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“…[17][18][19] In the second way, necrobiotic collagen breaks hair follicle wall, causing anexal destruction. 20 The entire process is allowed to thanks the inflammation of abnormal dermal components (collagen, elastin or even cholesterol crystals). 13,15 Clinically lesions begin with asymptomatic erythematous plaques, with raised dusky red border, with slow growth and outer come do--like lesions which leave a crater like depression when are removed (transfollicular elimination) or with kyperkeratotic papules (transepidermal elimination).…”

Section: Discussionmentioning

confidence: 99%

Case number 19th of perforating necrobiosislipoidica worldwide

calle

Espinosa

Ruíz

2018

JDC

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Perforating necrobiosislipoidica is a secondary perforating disease with necrobiotic collagen elimination through the epidermis in diabetic patients. Lesions are very similar to classic necrobiosislipoidica but in the former there are keratotic plugs over the raised borders of the atrophic yellow plaques. It is explained by necrotic collagen on upper dermis causing inflammation and breaking on through the hair follicle wall or abnormal channels connecting dermis with the outside. In spite of its low frequency, this manuscript highlights the first case reported in Colombia, the 19th case worldwide.

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“…However, this report was not substantiated with histopathologic findings. Since 1915, only four subsequent cases of granuloma annulare that occurred in a perifollicular pattern have been reported; three of these cases were rare perforating forms of GA that were characterized by transepidermal elimination of necrobiotic material through the hair follicle unit [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

Generalized granuloma annulare in a folliculocentric distribution

Rothman

Mir

Meehan

2015

Dermatology Online Journal

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We present a 69-year-old man with type 2 diabetes mellitus and a five-year history of an eruption of follicular pustules, papules, and nodules, which was identified histopathologically as folliculocentric granuloma annulare (GA). Folliculocentric generalized GA is a rarely reported variant of GA, in which the the palisading histiocytes form focal granulomas in a follicular pattern. In this case, the GA may represent an isotopic phenomenon, with lesions developing in hair follicles that were previously affected by a suppurative folliculitis. Case synopsisHistory: A 69-year-old man presented to the Skin and Cancer Unit for evaluation of a generalized eruption of red-to-purple, mildly pruritic, non-tender papules and nodules, which spared his face, palms, and soles. The eruption had been ongoing for five years at the time of his presentation. The lesions were sometimes vesicular or pustular, and exuded a yellow discharge. He denied any systemic symptoms. Other medical problems include asbestosis (without mesothelioma), type II diabetes mellitus, and hypertension. No medications were started or changed before the eruption developed.Prior to his presentation at the Skin and Cancer Unit, a dermatologist treated the condition with doxycycline, which was used at the onset of the eruption and which helped modestly. He was later treated by other dermatologists with valacyclovir, topical glucocorticoids, and ketoconazole, none of which helped. Physical examination:In a widespread distribution on the trunk and extremities with sparing of the head, neck, palms, soles, and genitals, crops of erythematous-to-violaceous papules, pustules, and nodules were present. Scattered excoriations were noted. A few crusted lesions were present on the trunk, with occasional vesicles on erythematous bases. Laboratory data:A complete blood count and comprehensive metabolic panel were normal. Hepatitis B virus surface antigen, surface antibody, and core antibody; hepatitis C virus antibody; human immunodeficiency virus; and QuantiFERON-TB Gold were negative.Histopathology: There is a perifollicular, nodular and interstitial, mixed-cell infiltrate of histiocytes with scattered eosinophils and neutrophils. There are foci of histiocytic aggregates surrounding areas of mucin.

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Granuloma annulare with Follicular Perforation

Cited by 18 publications

References 7 publications

Case number 19th of perforating necrobiosis lipoidica worldwide

Case number 19th of perforating necrobiosis lipoidica worldwide

Case number 19th of perforating necrobiosislipoidica worldwide

Generalized granuloma annulare in a folliculocentric distribution

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