Responses of Prepubertal Female Rats to Environmental PCBs with High and Low Dioxin Equivalencies

LI, MEI-HUI; HANSEN, LARRY G.

doi:10.1093/toxsci/33.2.282

Cited by 7 publications

(9 citation statements)

References 41 publications

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“…5a), which is in accordance with the increase in EROD activity following exposure to PCP observed in quail hepatocytes (Verbrugge et al, 2001). Previous studies have revealed that BROD can be induced by phenobarbital, hexachlorobenzene, and PCBs (Li and Hansen, 1996;Parente et al, 2009;Smith et al, 1993). In the present study, however, BROD activity was not significantly different after PCP exposure.…”

Section: Effect Of Pcp On Activities Of Alkoxyresorufin O-dealkylase supporting

confidence: 91%

Effects of pentachlorophenol on the detoxification system in white-rumped munia ( Lonchura striata )

Jiang

Wang

Zhang³

et al. 2016

Journal of Environmental Sciences

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Section: Effect Of Pcp On Activities Of Alkoxyresorufin O-dealkylase supporting

confidence: 91%

Effects of pentachlorophenol on the detoxification system in white-rumped munia ( Lonchura striata )

Jiang

Wang

Zhang³

et al. 2016

Journal of Environmental Sciences

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“…2 Correspondence: R.Z. Kovacevic trachloro-␥-dioxin (TCDD), polychlorinated dibenzofurans (PCDFs), and related substances [14][15][16]. The mono-orthosubstituted PCB congeners also bind to the cytosolic Ahreceptor, but with lower potency than coplanar congeners.…”

Section: Introductionmentioning

confidence: 99%

“…[7]. The PCBs with two or more ortho-chlorines exhibit low or no affinity for the Ah-receptors [17][18][19] but can induce hormone-and neurotransmitter-like effects [14][15][16]. For example, some PCBs exhibit estrogenic and antiestrogenic actions that may contribute in altering the reproductive function [20].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Rat Testicular Androgenesis by a Polychlorinated Biphenyl Mixture Aroclor 12481

Andrić

Kostic

Stojilković

et al. 2000

Biology of Reproduction

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Polychlorinated biphenyls (PCBs) are complex mixtures of congeners that exhibit carcinogenic and toxicant activities in a variety of mammalian tissues. Here, we studied the acute in vivo and in vitro effects of a commercially used PCB product, Aroclor 1248 (A1248), a mixture of tri-, tetra-, and pentachloro congeners. Single intraperitoneal (i.p.) or bilateral intratesticular (i.t.) injections of A1248 decreased serum androgen levels in both groups 24 h after injection. Chorionic gonadotropin-stimulated androgen production by acute testicular cultures from both groups was also reduced, and progesterone production was attenuated in cultures from i.t.-treated animals. The capacity of the postmitochondrial fractions from testes of i.t.-treated animals to convert pregnenolone to progesterone and progesterone to testosterone was reduced as well. In vitro studies revealed that a 10- to 15-min exposure of postmitochondrial testicular fractions and intact interstitial cells from normal animals to A1248 in a subnanomolar concentration range was sufficient to attenuate the conversion of pregnenolone to progesterone and progesterone to testosterone. At micromolar concentrations, A1248 added in vitro also inhibited the conversion of Delta(4)-androstendione to testosterone without affecting the viability of interstitial cells. These results indicate that A1248 down-regulates the testicular androgenesis by an acute inhibition of 3beta-hydroxysteroid dehydrogenase, 17alpha-hydroxylase/lyase, and 17beta-hydroxysteroid dehydrogenase activities.

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“…Simple chemical separations that alter the composition of CB profiles of commercial mixtures can also dramatically change response profiles in laboratory animals (e.g. 33,34 ). Thus, for humans exposed to more radically altered PCB profiles, more complete CB profiles are needed to appropriately select individuals for medical surveillance and/or medical intervention.…”

Section: Discussionmentioning

confidence: 99%

Concentrations and Frequencies of Polychlorinated Biphenyl Congeners in a Native American Population That Consumes Great Lakes Fish

Gerstenberger

Dellinger

Hansen

2000

Journal of Toxicology: Clinical Toxicology

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When compared to other human residue analyses for fish-eating populations, the Ojibwa samples contained higher proportions of lightly chlorinated and labile chlorobiphenyls such as 8, 16 + 32, 17, 18, 25, 41 + 64 + 71, 33, 52, 110, and 129. These proportions were similar to those found in carp, whitefish, or whitefish livers harvested from the Great Lakes region. These data indicate that regular meals of lower trophic level fish, such as whitefish from the Great Lakes, may distort steady-state human chlorobiphenyl profiles with respect to certain lightly chlorinated or labile chlorobiphenyls.

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Responses of Prepubertal Female Rats to Environmental PCBs with High and Low Dioxin Equivalencies

Cited by 7 publications

References 41 publications

Effects of pentachlorophenol on the detoxification system in white-rumped munia ( Lonchura striata )

Effects of pentachlorophenol on the detoxification system in white-rumped munia ( Lonchura striata )

Inhibition of Rat Testicular Androgenesis by a Polychlorinated Biphenyl Mixture Aroclor 12481

Concentrations and Frequencies of Polychlorinated Biphenyl Congeners in a Native American Population That Consumes Great Lakes Fish

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