Concentrations and Frequencies of Polychlorinated Biphenyl Congeners in a Native American Population That Consumes Great Lakes Fish

Gerstenberger, Shawn; Dellinger, John A.; Hansen, Larry G.

doi:10.1081/clt-100102386

Cited by 24 publications

(12 citation statements)

References 31 publications

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“…PCBs, PCDD/Fs, and organochlorine pesticides have been associated with a variety of adverse health effects, and, in the populations consuming fish from the Great Lakes–St. Lawrence system, have been adversely associated with neurodevelopment and cognition in children (Jacobson et al 1985, 1990; Lonky et al 1996; Stewart et al 2008) and adults (Haase et al 2009; Schantz et al 2001), in utero growth (Fein et al 1984; Karmaus and Zhu 2004; Weisskopf et al 2005), reproduction (Buck et al 2000; Buck Louis et al 2009; Courval et al 1999), immune function (Schell and Gallo 2010), thyroid and steroid hormone regulation (Persky et al 2001; Schell and Gallo 2010), diabetes (Codru et al 2007; Gerstenberger et al 2000; Turyk et al 2009), and cardiovascular disease (Goncharov et al 2008). However, fish consumption has not been associated with adverse health outcomes in all studies (e.g., Buck et al 1999; Dellinger 2004).…”

Section: Contaminants and Great Lakes Fishmentioning

confidence: 99%

Risks and Benefits of Consumption of Great Lakes Fish

Turyk

Bhavsar

Bowerman

et al. 2012

Environ Health Perspect

110

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Background: Beneficial effects of fish consumption on early cognitive development and cardiovascular health have been attributed to the omega-3 fatty acids in fish and fish oils, but toxic chemicals in fish may adversely affect these health outcomes. Risk–benefit assessments of fish consumption have frequently focused on methylmercury and omega-3 fatty acids, not persistent pollutants such as polychlorinated biphenyls, and none have evaluated Great Lakes fish consumption.Objectives: The risks and benefits of fish consumption have been established primarily for marine fish. Here, we examine whether sufficient data are available to evaluate the risks and benefits of eating freshwater fish from the Great Lakes.Methods: We used a scoping review to integrate information from multiple state, provincial, and federal agency sources regarding the contaminants and omega-3 fatty acids in Great Lakes fish and fish consumers, consumption rates and fish consumption advisories, and health effects of contaminants and omega-3 fatty acids.Data synthesis: Great Lakes fish contain persistent contaminants—many of which have documented adverse health effects —that accumulate in humans consuming them. In contrast, data are sparse on omega-3 fatty acids in the fish and their consumers. Moreover, few studies have documented the social and cultural benefits of Great Lakes fish consumption, particularly for subsistence fishers and native communities. At this time, federal and state/provincial governments provide fish consumption advisories based solely on risk.Conclusions: Our knowledge of Great Lakes fish has critical gaps, particularly regarding the benefits of consumption. A risk–benefit analysis requires more information than is currently available on the concentration of omega-3 fatty acids in Great Lakes fish and their absorption by fish eaters in addition to more information on the social, cultural, and health consequences of changes in the amount of fish consumed.

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Section: Contaminants and Great Lakes Fishmentioning

confidence: 99%

Risks and Benefits of Consumption of Great Lakes Fish

Turyk

Bhavsar

Bowerman

et al. 2012

Environ Health Perspect

110

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“…The bottom central cluster of five pie charts (again same species) show the relative proportion of their di-, tri-, tetra-, penta-, hexa-, hepta-, and octacontaminants. The standard-and-proportional-pie charts are placed next to one another in an attempt to associate and highlight suspect adverse health effects with PCB-congener estimated exposure dose (46)(47)(48)(49)(50). (View this art in color at www.dekker.com.)…”

Section: Ojibwa Nutrition and Pcb Tissue Contamination Levelsmentioning

confidence: 99%

Epidemiologic Studies of PCB Congener Profiles in North American Fish Consuming Populations

Chiu

Beaubier

Chiu

et al. 2004

Journal of Environmental Science and Health, Part C

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Long range atmospheric and stream transport and oceanic currents drive the ecologic process of PCB deposition in the abiotic environment. In contrast short range transport via bioaccumulation-biomagnification up the food chain determines PCB congener profiles and concentrations and their adverse effects in biological organisms. Two research approaches to congeners, with potential to associate specific adverse human health effects with PCB concentrations in indigenous small populations, are summarized in this study. The field epidemiological approach includes giving questionnaires to target population groups in conjunction with sampling for PCBs (and selected persistent organic pollutants and metals), in foods purchased or hunted and collected by Inuit peoples. Direct determination of contaminant levels in food sources and among individuals in selected comparative subpopulations is also presented.

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“…However, humans and ecological receptors still continue to be exposed to these chemicals because of their persistence and the large accumulated reserves. PCB congeners have frequently been detected in combination in human tissues during epidemiological and biomonitoring studies (Dewailly et al, 1993(Dewailly et al, , 1999Chevrier et al, 2000;Aronson et al, 2000;Gerstenberger et al, 2000).…”

mentioning

confidence: 99%

Physiologically Based Modeling of the Accumulation in Plasma and Tissue Lipids of a Mixture of PCB Congeners in Female Sprague-Dawley Rats

Emond

Charbonneau

Krishnan

2005

Journal of Toxicology and Environmental Health, Part A

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This study aimed to develop a physiologically based model for simulating the concentrations of polychlorinated biphenyls (PCBs) in tissue and plasma lipids of rats exposed to PCB mixtures. The model was based on the assumption that the neutral lipid fraction is the only critical determinant of the tissue distribution of PCBs, and that the solubility/retention in other tissue components is negligible. The volumes of the model compartments reflected the volumes of neutral lipids, whereas the flow rates corresponded to those of the neutral lipids in blood. Since the equilibrium ratio of PCB concentrations in neutral lipids of tissues and plasma equals 1, the present modeling approach does not require the use of tissue:blood partition coefficients. Metabolism rates were derived from the best visual fit of the model to the PCB concentrations in hepatic lipids determined on d 41 and 90 in rats exposed to a mixture containing 5, 50, or 500 microg PCBs (118, 138, 153, 170, 180 and 187) per kilogram body weight according to various protocols: (a) every-day dosing, (b) once-a-week dosing, (c) consecutive dosing for 13 d with no further treatment, and (d) 13 irregularly spaced doses. The resulting model consistently simulated the concentrations of PCBs in adipose tissue and plasma lipids of rats exposed according to the four described protocols. The physiologically based pharmacokinetic (PBPK) model developed in this study should be useful as a basis for interpretating blood or plasma lipid concentration data on PCBs collected during biomonitoring studies.

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Concentrations and Frequencies of Polychlorinated Biphenyl Congeners in a Native American Population That Consumes Great Lakes Fish

Cited by 24 publications

References 31 publications

Risks and Benefits of Consumption of Great Lakes Fish

Risks and Benefits of Consumption of Great Lakes Fish

Epidemiologic Studies of PCB Congener Profiles in North American Fish Consuming Populations

Physiologically Based Modeling of the Accumulation in Plasma and Tissue Lipids of a Mixture of PCB Congeners in Female Sprague-Dawley Rats

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