Response to Ring et al.: In Silico Predictive Metagenomic Analyses Highlight Key Metabolic Pathways Impacted in the Hidradenitis Suppurativa Skin Microbiome

Schneider, Andreá; Cook, Lawrence; Zhan, Xiang; Banerjee, Kalins; Cong, Zhaoyuan; Imamura, Yuka; Gettle, Samantha L.; Longenecker, Amy L.; Kirby, Joslyn S.; Nelson, Amanda M.

doi:10.1016/j.jid.2020.02.003

Cited by 1 publication

(2 citation statements)

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“…In their predictive metagenomic analyses, the researchers identified a total of nine pathways in common between both data sets and analyses pipelines. The authors confirmed a possible higher microbial turnover and/or proliferation in HS skin, whereas glyoxylate and dicarboxylate metabolism was significantly decreased in HS lesional skin [ 57 ].…”

Section: Microbes and Hs: Evidence To Datementioning

confidence: 76%

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Consistency of Bacterial Triggers in the Pathogenesis of Hidradenitis Suppurativa

et al. 2023

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Hidradenitis suppurativa (HS) is an inflammatory skin disease whose pathogenesis remains poorly defined. Over the past decades, the bacterial role in HS patients has been a focus of research. According to the literature, the HS skin (and probably gut) bacterial composition is different to that of healthy controls. To date, a key question is whether compositional changes in the microbial populations are responsible for the development of HS (primum movens), or only secondarily reflect the ongoing inflammatory process. The great diversity of methodologies that have been used to study microbial role in HS have led to an accumulation of conflicting results. Thus, in view of these considerations, the aim of this article is to provide the reader with an overview about different hypotheses proposed to explain the bacterial role in HS pathogenesis.

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Section: Microbes and Hs: Evidence To Datementioning

confidence: 76%

“…and Porphyromonas spp.) would thus decrease [ 38 , 39 , 56 , 57 ]. It is therefore reasonable to propose probiotics in HS as a potential treatment option [ 58 ].…”

Section: Microbes and Hs: Evidence To Datementioning

confidence: 99%