Response to Letters Regarding Article, “Randomized Trial of Atorvastatin for Reduction of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: Results of the ARMYDA-3 (Atorvastatin for Reduction of Myocardial Dysrhythmia After Cardiac Surgery) Study”

Patti, Giuseppe; Chello, Massimo; Candura, Dario; D’Ambrosio, Andrea; Covino, Elvio; Sciascio, Germano Di; Pasceri, Vincenzo

doi:10.1161/circulationaha.106.682484

Cited by 145 publications

(268 citation statements)

References 2 publications

(2 reference statements)

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“…Different treatment strategies have been devised and tested in the clinical setting with the aim of reducing the incidence of postoperative AF in the cardiac surgical patient population. These include the administration of beta blockers, amiodarone, statins and ACE inhibitors [2,4,19,[20][21][22]. The main origin of BNP is the ventricular myocardium, although the atria may be responsible for some of its production [23].…”

Section: Discussionmentioning

confidence: 99%

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NT-pro-BNP, but not C-reactive protein, is predictive of atrial fibrillation in patients undergoing coronary artery bypass surgery

Gašparović

Burcar

Kopjar

et al. 2010

European Journal of Cardio-Thoracic Surgery

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Section: Discussionmentioning

confidence: 99%

“…Notably, the recruitment of older patients into the contemporary cardiac surgical referral pattern is reflected by an increasing incidence of postoperative AF [1,4]. Atrial fibrillation may present as a benign and self-limiting disorder.…”

Section: Introductionmentioning

confidence: 99%

NT-pro-BNP, but not C-reactive protein, is predictive of atrial fibrillation in patients undergoing coronary artery bypass surgery

Gašparović

Burcar

Kopjar

et al. 2010

European Journal of Cardio-Thoracic Surgery

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“…Additionally, the Atorvastatin for Reduction of Post-operative Atrial Fibrillation in Patients Undergoing Cardiac Surgery (ARMYDA-3) Study [85] demonstrated that atorvastatin 40 mg/day when administered 1 week before elective cardiac surgery with cardiopulmonary bypass in 200 patients significantly decreased the incidence of post-operative AF as compared to placebo (35% in the atorvastatin group vs 57% in the placebo group) [odds ratio 0.39 (0.18-0.85), p = 0.017]. ARMYDA-3 was a well-designed study without having major limitations.…”

Section: Clinical and Experimental Evidencementioning

confidence: 99%

Do statins have an antiarrhythmic activity?

Kostapanos

Liberopoulos

Goudevenos

et al. 2007

Cardiovascular Research

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Sudden cardiac death, which is mainly associated with the presence of life-threatening ventricular arrhythmias, is a common 'killer' among patients with coronary artery disease. Moreover, atrial fibrillation is the most common arrhythmia encountered in the clinical practice. The beneficial effect of statins on cardiovascular morbidity and mortality is well-established, while the exact role of this class of drugs against arrhythmias remains unclear. This review discusses the effect of statin treatment on arrhythmias that are commonly seen in the clinical setting. The underlying pathophysiological mechanisms are also overviewed. Compelling evidence from the majority of the studies reviewed shows that statins exhibit a protective effect against the occurrence of ventricular arrhythmias and atrial fibrillation.

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“…In der Folge zeigen diese Patienten eine vermehrte Morbidität durch neurologische, renale und infektiologische Komplikationen. Postoperatives Vorhofflimmern führt darüber hinaus zu verlängertem Krankenhausaufenthalt und damit zu einem höheren Ressourcenverbrauch [5,22,24,27].…”

Section: Vorhofflimmernunclassified

“…Die Gabe von Digoxin oder Verapamil bietet keine prophylaktische Wirkung [13]. Die ARMYDA-3-Studie konnte bei 200 Patienten eine Reduktion des Auftretens von postoperativem Vorhofflimmern durch die 7-tägige Vorbehandlung mit Atorvastatin (40 mg/Tag) erzielen [27], die praktisch-klinische Bedeutung dieser Beobachtung ist noch offen.…”

Section: Vorhofflimmernunclassified

Aortokoronare Bypass- und Herzklappenoperationen

Fischer

Drexler

2007

Internist

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In Germany, approximately 100,000 patients underwent cardiac surgery in 2005. The most important postoperative problems with prognostic impact for these patients were acute heart failure, acute renal failure, infections, neurological complications, postcardiotomy syndrome, cardiac tamponade and atrial fibrillation. The "EuroSCORE" is a relevant predictor of immediate and long-term outcome in these patients. The patency rates of coronary artery bypass grafts (CABG) are important for the long-term outcome in such surgery. There has been a significant increase in the number of patients aged 80 years and older who are referred for cardiac surgery, which is an outstanding challenge for cardiac surgeons.

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Response to Letters Regarding Article, “Randomized Trial of Atorvastatin for Reduction of Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery: Results of the ARMYDA-3 (Atorvastatin for Reduction of Myocardial Dysrhythmia After Cardiac Surgery) Study”

Cited by 145 publications

References 2 publications

NT-pro-BNP, but not C-reactive protein, is predictive of atrial fibrillation in patients undergoing coronary artery bypass surgery

NT-pro-BNP, but not C-reactive protein, is predictive of atrial fibrillation in patients undergoing coronary artery bypass surgery

Do statins have an antiarrhythmic activity?

Aortokoronare Bypass- und Herzklappenoperationen

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