NT-pro-BNP, but not C-reactive protein, is predictive of atrial fibrillation in patients undergoing coronary artery bypass surgery

Gašparović, Hrvoje; Burcar, Ivan; Kopjar, Tomislav; Vojković, Jakov; Gabelica, Rajka; Biočina, Bojan; Jelić, Ivan

doi:10.1016/j.ejcts.2009.07.003

Cited by 32 publications

(44 citation statements)

References 25 publications

(40 reference statements)

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“…They concluded that preoperative NT-pro-BNP, duration of cardiopulmonary bypass and advanced age were the independent predictors. 34 Iskesen I, et al reported the same situation and concluded the positive correlation between high levels of preoperative NT-pro-BNP and risk of new-onset AF after conventional CABG. 35 Kerbaul F reported that preoperative and postoperative NT-pro-BNP levels after OPCAB could predict cardiovascular complications.…”

Section: -23�mentioning

confidence: 78%

Preoperative High N-Terminal pro-B-Type Natriuretic Peptide Level Can Predict the Incidence of Postoperative Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

Matsuura

Mogi

Sakurai

et al. 2013

ATCS

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Objective: N-terminal pro-B type natriuretic peptide (NT-pro-BNP) is one of the biomarkers, increased by myocardial ischemia or subsequent, burdened wall stress. The aim of this study was to assess if NT-pro-BNP can predict the incidence of atrial fibrillation (AF) after off-pump coronary artery bypass grafting (OPCAB). Methods: NT-pro-BNP was measured preoperatively in 100 OPCAB patients without preoperative AF. Patients were divided into the AF group (n = 36) of those who developed postoperative AF, and the sinus rhythm (SR) group (n = 64), of those who did not. Odds ratio analysis was carried out with a logistic regression model using the threshold of the high quartile. Results: Age was more advanced in group AF (70.8 ± 8.7 years old) than in group SR (66.7 ± 8.5 years old), P = 0 025. There were more emergencies in group AF (22.2%) than in group SR (10.9%), P = 0 15. Preoperative NT-pro-BNP was significantly higher in group AF (509.6 ± 641.6 pg/mL) than in group SR (241.1 ± 302.7 pg/mL), P = 0 006. Preoperative administration of statins was relatively greater in group SR (73.4%) than in group AF (58.3%), P = 0 18. Four factors with a P value below 0.2 in the univariate analysis were extracted, which were preoperative administration of statins, emergency, high NT-pro-BNP (>348 pg/mL, high quartile), and advanced age (>75 years old, high quartile). The constructed logistic regression model revealed that high NT-pro-BNP (>348 pg/mL, high quartile) was the only predictor of postoperative AF after OPCAB (P = 0 05; OR, 2.60; 95% CI, 0.96-7.05). Conclusions: A high preoperative level of NT-pro-BNP could predict the incidence of postoperative AF after OPCAB.Keywords: coronary artery disease, outcomes, ischemic heart disease Objective: N-terminal pro-B type natriuretic peptide (NT-pro-BNP) is one of the biomarkers, increased by myocardial ischemia or subsequent, burdened wall stress. The aim of this study was to assess if NT-pro-BNP can predict the incidence of atrial fibrillation (AF) after off-pump coronary artery bypass grafting (OPCAB). Methods: NT-pro-BNP was measured preoperatively in 100 OPCAB patients without preoperative AF. Patients were divided into the AF group (n = 36) of those who developed postoperative AF, and the sinus rhythm (SR) group (n = 64), of those who did not. Odds ratio analysis was carried out with a logistic regression model using the threshold of the high quartile. Results: Age was more advanced in group AF (70.8 ± 8.7 years old) than in group SR (66.7 ± 8.5 years old), P = 0 025. There were more emergencies in group AF (22.2%) than in group SR (10.9%), P = 0 15. Preoperative NT-pro-BNP was significantly higher in group AF (509.6 ± 641.6 pg/mL) than in group SR (241.1 ± 302.7 pg/mL), P = 0 006. Preoperative administration of statins was relatively greater in group SR (73.4%) than in group AF (58.3%), P = 0 18. Four factors with a P value below 0.2 in the univariate analysis were extracted, which were preoperative administration of statins, emergency, high NT-pro-BNP (>348 pg/mL, high quar...

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Section: -23�mentioning

confidence: 78%

Preoperative High N-Terminal pro-B-Type Natriuretic Peptide Level Can Predict the Incidence of Postoperative Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

Matsuura

Mogi

Sakurai

et al. 2013

ATCS

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“…Significant associations between dense spontaneous echo contrast and the 2 indexes, Creactive protein and soluble P-selection, support the hypothesis of increased inflammatory activity for thrombogenesis in AF (5). Inflammatory markers play an important role in the development of AF, although the results are not consistent (3). An association of preoperative platelet activity and POAF has been shown previously (21,22).…”

Section: Commentmentioning

confidence: 86%

“…Due to the lack of data describing the time point when POAF occurred after CABG in our analysis, one could argue against our hypothesis of an association between POAF and HAPR. When analyzing the available data on the time association of POAF and open-heart surgery, most reports indicate the highest incidence within the first 4 days following the procedure, peaking around the second day (3,20). Therefore, if the timing of postoperative PFT was synchronized with the timing of POAF, the association effect of POAF and HAPR could only have been stronger.…”

Section: Commentmentioning

confidence: 99%

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Postoperative Atrial Fibrillation Is Associated With High On-Aspirin Platelet Reactivity

Kopjar¹,

Petričević²,

Gašparović³

et al. 2015

The Annals of Thoracic Surgery

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“…I am very glad to see that Dr Shih et al reported my case of haemomediastinum caused by a ruptured bronchial artery aneurysm [1]. This is one of the bronchial arterial embolisation cases that I performed during October 2006.…”

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confidence: 94%

Where is the ruptured bronchial artery aneurysm?☆

Hung

2010

European Journal of Cardio-Thoracic Surgery

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NT-pro-BNP, but not C-reactive protein, is predictive of atrial fibrillation in patients undergoing coronary artery bypass surgery

Cited by 32 publications

References 25 publications

Preoperative High N-Terminal pro-B-Type Natriuretic Peptide Level Can Predict the Incidence of Postoperative Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

Preoperative High N-Terminal pro-B-Type Natriuretic Peptide Level Can Predict the Incidence of Postoperative Atrial Fibrillation Following Off-Pump Coronary Artery Bypass Grafting

Postoperative Atrial Fibrillation Is Associated With High On-Aspirin Platelet Reactivity

Where is the ruptured bronchial artery aneurysm?☆

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