Response to Letter Regarding Article, “Atrial Fibrillation Begets Heart Failure and Vice Versa: Temporal Associations and Differences in Preserved Versus Reduced Ejection Fraction”

Santhanakrishnan, Rajalakshmi; Wang, Na; Larson, Martin G.; Magnani, Jared W.; McManus, David D.; Lubitz, Steven A.; Ellinor, Patrick T.; Cheng, Susan; Vasan, Ramachandran S.; Lee, Douglas S.; Wang, Thomas J.; Levy, Daniel; Benjamin, Emelia J.; Ho, Jennifer E.

doi:10.1161/circulationaha.116.022835

Cited by 258 publications

(400 citation statements)

References 6 publications

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“…Of these parameters, increasing age, history of chronic obstructive pulmonary disease, and increasing baseline creatinine were significant predictors. Increasing age and reduced lung function are well known to increase the risk of AAs . In recent studies examining the risk of new‐onset AF in heart failure patients without LVAD, increasing age, decreased left ventricular diastolic elastance, diabetes mellitus, hypertension, increased diuretic use, and renal impairment were found to be predictors of AF .…”

Section: Discussionmentioning

confidence: 99%

Atrial Arrhythmias and Electroanatomical Remodeling in Patients With Left Ventricular Assist Devices

Deshmukh

Kim

Burke

et al. 2017

JAHA

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BackgroundThe incidence, predictors, and impact of atrial arrhythmias along with left atrial structural changes in patients with left ventricular assist devices (LVADs) remain undetermined.Methods and ResultsAll patients who underwent LVAD implantation from 2008 to 2015 at the University of Chicago Medical Center were included. Electronic medical records, electrocardiograms, echocardiograms, and cardiac electrical device interrogations were reviewed. The association of arrhythmias and clinical covariates with survival was evaluated by Kaplan–Meier and Cox proportional hazards analyses. A total of 331 patients were followed for a median of 330 days (range 0–2306 days). Mean age was 57.8±12.8 years, 256 participants (77.3%) were male, mean left ventricular ejection fraction was 20±6.6%, and 124 (37.5%) had ischemic cardiomyopathy. Atrial arrhythmias (53.8%) were highly prevalent and frequently coexisted before LVAD implantation: atrial fibrillation (AF) in 45.9%, atrial flutter in 13.9%, atrial tachycardia in 6.9%, and atrioventricular nodal reentrant tachycardia in 1.2%. New‐onset AF was documented in 14 patients (7.8% of patients without prior AF) after the first 30 days with an LVAD. Increasing age, renal insufficiency, and lung disease were predictors of new‐onset AF after LVAD implantation. Of patients with paroxysmal AF, 43% had no further AF after LVAD. Left atrial size and volume index improved with LVAD (P<0.005). History of persistent AF, atrial tachycardia, ventricular arrhythmia, coronary artery bypass, and low albumin were associated with decreased survival.ConclusionsAtrial arrhythmias are significantly prevalent in patients who require LVAD and are associated with increased mortality; however, LVADs induce favorable atrial structural and electrical remodeling.

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Section: Discussionmentioning

confidence: 99%

Atrial Arrhythmias and Electroanatomical Remodeling in Patients With Left Ventricular Assist Devices

Deshmukh

Kim

Burke

et al. 2017

JAHA

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“…It has been found that the percentage of HF patients who also present AF ranges from 10 to 57% . The two conditions share some risk factors such as valvular heart disease, hypertension, diabetes, and myocardial infarction …”

Section: Introductionmentioning

confidence: 99%

Mortality in heart failure with atrial fibrillation: Role of digoxin and diuretics

Gonzalez-Loyola

Abellana

Verdú-Rotellar

et al. 2018

Eur J Clin Investigation

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“…Similarly as discussed for AF progression, heart failure and AF are two closely inter-related diseases that share common pathophysiological pathways and perpetuate each other 18. Hence, permanent AF may reflect a more advanced AF disease state that could be associated with manifestation of heart failure.…”

Section: Discussionmentioning

confidence: 93%

Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes

Schnabel

Pecen

Engler

et al. 2018

Heart

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Response to Letter Regarding Article, “Atrial Fibrillation Begets Heart Failure and Vice Versa: Temporal Associations and Differences in Preserved Versus Reduced Ejection Fraction”

Cited by 258 publications

References 6 publications

Atrial Arrhythmias and Electroanatomical Remodeling in Patients With Left Ventricular Assist Devices

Atrial Arrhythmias and Electroanatomical Remodeling in Patients With Left Ventricular Assist Devices

Mortality in heart failure with atrial fibrillation: Role of digoxin and diuretics

Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes

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