Response to experimentally induced infection with bovine respiratory syncytial virus following intranasal vaccination of seropositive and seronegative calves

Abstract

Maternal antibodies may inhibit priming of protective responses by IN delivered BRSV vaccines.

Animal models of respiratory syncytial virus infection

“…The findings from these studies are similar to those seen in chimpanzees infected with analogous mutants of hRSV [31]. Calves have been used to evaluate hRSV vaccine concepts such as DNA vaccines [137], subunit vaccines [138], immunostimulating complexes (ISCOMs) [139], live attenuated viruses [140], recombinant virus vectors [141], [142], and novel adjuvants with inactivated bRSV [143], and to determine the effects of maternal antibodies on vaccination [144]. Calves can also be part of the preclinical assessment of hRSV vaccine candidates which contain proteins that are conserved between hRSV and bRSV.…”

Nasal vaccination of young rainbow trout ( Oncorhynchus mykiss ) against infectious hematopoietic necrosis and enteric red mouth disease

“…Nasal vaccination of young children as well as newborn mice, piglets, calves and chickens (Guzman-Bautista et al, 2014;Sandbulte et al, 2014;Sabirov and Metzger, 2008;Ellis et al, 2010;Lancaster et al, 1960) has been performed successfully. Interestingly, the power of diffuse NALT to induce effective immunity following nasal vaccination in the absence of organized NALT was unequivocally demonstrated in newborn mice whose organized NALT had been surgically removed (Sabirov and Metzger, 2008).…”

“…The use of this delivery route has been tested in small trout but age was not controlled in those studies. Nasal vaccination of young non-aquatic vertebrates such as piglets, newborn mice, calves and rabbits (Guzman-Bautista et al, 2014;Sandbulte et al, 2014;Sabirov and Metzger, 2008;Ellis et al, 2010;Lancaster et al, 1960) is feasible, effective and does not induce tolerance. In fact, the human nasal vaccine FluMist (LAIV) is recommended for use in young infants (6e59 months) since it prevents about 50% more cases than the injected flu vaccine (TIV) at this age (Carter and Curran, 2011).…”

Bovine respiratory syncytial virus ISCOMs—Immunity, protection and safety in young conventional calves

“…Nasal administration of a live attenuated vaccine has recently been commercialized and is partially protective in this target group of animals [20,21]. However, this vaccine virus is shed for long periods [22], conferring a risk for passage to sentinel calves, which could potentially increase its virulence.…”