2003
DOI: 10.1038/sj.leu.2402802
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Cited by 8 publications
(13 citation statements)
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“…For hyperdiploidy, we assessed on SNP arrays trisomies of the chromosomes 3,5,7,9,11,15,17,18,19, and 21. Because it has been shown in childhood acute lymphoblastic leukemia 10 and myeloma 11 that the number of trisomies is important for outcome (hyperdiploidy .50 was associated with a better outcome than hyperdiploidy 47 to 50), we also counted the number of chromosomes on the SNP arrays for each patient and defined hypodiploidy (,46 chromosomes), pseudodiploidy (46 chromosomes), mild hyperdiploidy (47 to 50 chromosomes), and large hyperdiploidy (.50 chromosomes)…”
Section: Methodsmentioning
confidence: 99%
“…For hyperdiploidy, we assessed on SNP arrays trisomies of the chromosomes 3,5,7,9,11,15,17,18,19, and 21. Because it has been shown in childhood acute lymphoblastic leukemia 10 and myeloma 11 that the number of trisomies is important for outcome (hyperdiploidy .50 was associated with a better outcome than hyperdiploidy 47 to 50), we also counted the number of chromosomes on the SNP arrays for each patient and defined hypodiploidy (,46 chromosomes), pseudodiploidy (46 chromosomes), mild hyperdiploidy (47 to 50 chromosomes), and large hyperdiploidy (.50 chromosomes)…”
Section: Methodsmentioning
confidence: 99%
“…17,18 However, the prognostic value of these combinations has not been validated by other protocols. 4,5,13 Few studies have focused on the prognostic impact of structural abnormalities observed in HD.50. The poorer outcome initially reported by Pui et al 19 has not been corroborated by other large series with long follow-ups, 4,5,13 except for 2 reports relying on small series of patients.…”
Section: Introductionmentioning
confidence: 99%
“…4,5,13 Few studies have focused on the prognostic impact of structural abnormalities observed in HD.50. The poorer outcome initially reported by Pui et al 19 has not been corroborated by other large series with long follow-ups, 4,5,13 except for 2 reports relying on small series of patients. 20,21 Given this absence of consensus, the current trials use different criteria for identifying patients with best prognosis.…”
Section: Introductionmentioning
confidence: 99%
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