Response to Comment on Stegman et al. High-Intensity Statin Therapy Alters the Natural History of Diabetic Coronary Atherosclerosis: Insights From SATURN. Diabetes Care 2014;37:3114–3120

The effect of statins on the occurrence of peptic ulcer

“…Since mevalonic acid, the end product of said enzymatic reaction, is one of the foundational baseline substances to various isoprenoid metabolites [1,3], it could potentially lead to pleiotrophic effects of the aforementioned drugs. Also, growing evidence reveals that some other beneficial influence of these agents may have a significant effect on lowering plasma cholesterol levels [4][5][6][7][8]. As it appears, the positive effect surpasses the cholesterollowering result of statins through its protective effects on atherosclerotic plague stabilization and endothelial nitric oxide bioactivity [9,10].…”