Von Hippel-Lindau (VHL) disease is an autosomal dominant disease that produces a variety of tumors and cysts in the central nervous system and visceral organs, including renal cell carcinoma (RCC). RCC in patients with VHL disease does not frequently metastasize, therefore, the response to treatment and prognosis of metastatic RCC developed in patients with VHL disease has not been reported. Sunitinib is an oral, multitargeted receptor tyrosine kinase inhibitor with antiangiogenic and antitumor activity. Here, we report on four patients with metastatic RCC in VHL disease who received sunitinib and achieved partial responses that have lasted for a prolonged period of time.
873 or u = [ e -] q~( t ) = K " ( T ) P O~-' /~ (13)This theoretical value of -f/4 of the electrical conductivity dependence on the oxygen pressure agrees with the experimental value in the intrinsic range as shown in Figures We present calculations of alkali ion hydration energies for a variety of structures involving one to six water ligands. The method uses classical electrostatics with a previously described semiempirical selection of repulsive potential energies. The results are in excellent agreement with experimental gas phase data and available SCF calculations. We predict a stable tetrahedral inner hydration shell for Li+ and Na+ and obtain hE for a variety of structures involving four, five, and six ligands. We analyze individual energy terms in the bonding for Li+ and make detailed comparisons to SCF results to show the excellent absolute accuracy of our method. the correlation of molecular concepts of hydration as they relate to a variety of observable solution properties. In the present work we will investigate a specific simple method of hydration calculations and compare it to other results in this field. In addition, we will attempt to critically view the general problem of comparing such results to experiment.Three basic types of calculations have been done on ion hydration: electrostatic, a variety of simple quantum calcu-
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