Response to Comment on “A Liposomal System Capable of Generating CO₂ Bubbles to Induce Transient Cavitation, Lysosomal Rupturing and Cell Necrosis”

Abstract

Leroux et al. performed a set of experiments reported in our study and claim that they failed to reproduce the thermoresponsive liposomal system containing ammonium bicarbonate (ABC) that could trigger drug release under mild heating. We disagree with their assessments and speculate that the different method used by Leroux et al. to prepare the aqueous ABC is the culprit.

pH-Regulating Nanoplatform for the “Double Channel Chase ” of Tumor Cells by the Synergistic Cascade between Chlorine Treatment and Methionine-Depletion Starvation Therapy

“…The development of therapeutic gases, such as O 2 , CO 2 , NO and H 2 , offers more possibilities for cancer treatment. − Unfortunately, the leakage and uncontrolled release of gases during vascular transport have led to treatment failure as well as the potential risk of intoxication. , Therefore, the technology bottleneck in tumor ClO 2 treatment is to resolve the safe and effective transport of ClO 2 gas toward the tumor site and to achieve rapid responsive release of ClO 2 gas at the tumor site.…”